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Reposted by Benoit Ladoux

Max Planck Institute for the Science of Light (MPL) @mpi-scienceoflight.bsky.social · 19h

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.

mpl.mpg.de/news/article...
@fau.de

📸 Stephan Spangenberg

Professor Jochen Guck, Director at the Max Planck Institute for the Science of Light (MPL), He headed the division “Cell Physics” at MPL and the Max-Planck-Zentrum für Physik und Medizin (MPZPM).

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Reposted by Benoit Ladoux

Margaret Harris @drmlharris.bsky.social · 2d

Ahead of tomorrow’s #NobelPrize announcement, I went on a deep dive in search of the most obscure physics Nobel Prizes in history. That means it's time for a thread on...🧵

PHYSICS NOBEL PRIZES YOU’VE NEVER HEARD OF – PART 1

(1/n)

A photo of the Matterhorn rising above an Alpine landscape. The colours are a little washed out, but do not appear artificially tinted

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Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Isabela Corina Fortunato, PhD @icfortunato.bsky.social · 11d

Happy to share that my PhD has finally taken the shape of a paper! ✨

Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.

🧵👇

David Brückner @davidbrueckner.bsky.social · 12d

How do cells navigate up gradients of adhesive proteins?
🤔

Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood

We show that passive friction directs cells & explains complex trajectories on gradients

👉 www.nature.com/articles/s41...

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Reposted by Benoit Ladoux

Daniel J. Cohen (Princeton) @djcohen.bsky.social · 8d

So: can a cell hold hands with itself…and do we care? YES and YES! Read on to learn WHY, HOW, and what this has to do with…PARIS (and tree-hugging)? Swansong of Dr. Anamika; Hannah Kim on drums; and fantastic undergrads (Margaret/Lauren) ! 1/n
advanced.onlinelibrary.wiley.com/doi/10.1002/...

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Max Planck School Matter to Life @mattertolife.bsky.social · 8d

📣 Last chance to apply!
Applications for our URO program close tomorrow, October 1st.

Don't miss this opportunity:
mattertolife.maxplanckschools.org/uro-research...

👉 Funded 10-week research internship
👉 Learn from esteemed scientists
👉 No prior research experience required

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Reposted by Benoit Ladoux

Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Guillaume Charras @gcharras.bsky.social · 10d

Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.

More here: elifesciences.org/reviewed-pre...

elifesciences.org

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Reposted by Benoit Ladoux

Edouard Hannezo @ehannezo.bsky.social · 12d

Now out in final published form - with a new title "Mechanical control of cell fate decisions in the skin epidermis" and simulations/quantifications! See below for thread of how unbalanced tensions can bias fate choices in minimal 3D models of tissues! www.nature.com/articles/s41...

Edouard Hannezo @ehannezo.bsky.social · Dec 17

Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk

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epithelial mechanics fan club @epimechfc.bsky.social · 14d

Grata, A., & Levayer, R. (2025). Epithelial cell extrusion at a glance. Journal of Cell Science, 138(8), #EpithelialMechanicsReview doi.org/10.1242/jcs....

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Reposted by Benoit Ladoux

Vasily Zaburdaev @vasilyzaburdaev.bsky.social · 15d

Indeed, fantastic job Dr. Tim Klingberg! Big thanks to @lennarthilbert.bsky.social for coming over to Erlangen @fau.de for the defense and for all continued years of collaboration that led to this!

Lennart Hilbert @lennarthilbert.bsky.social · 15d

What a great doctoral defense by Tim Klingberg @fau.de

Based in the group of our collaborator @vasilyzaburdaev.bsky.social Tim decisively contributed to at least 3 of our own lab’s foundational projects, which he showed today at “Max Planck Zentrum Physik und Medizin”

Some impressions

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Benoit Ladoux @bladoux.bsky.social · 15d

Exciting science in Leipzig at the Physics of Cancer Meeting.
conference.uni-leipzig.de/poc/2025/

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Max Planck Institute for the Physics of Complex Systems @mpipks.bsky.social · 19d

IG Nobel Prize in #Physics 2025 to @mpipks.bsky.social researchers for elucidating the phase behaviour of cacio e pepe sauce. The work highlights how physics can also be applied to solve daily-life problems!

nature.com/articles/d41586-025-03045-0

Tipsy bats and perfect pasta: Ig Nobels celebrate ‘improbable’ research

The annual awards are a celebration of weird but thought-provoking science.

nature.com

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Reposted by Benoit Ladoux

Denis Duboule @denisduboule.bsky.social · 21d

Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr

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Benoit Ladoux @bladoux.bsky.social · 21d

We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.

mikeinmemoriam.sciencesconf.org

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Biophysical Paris @parisseminar.bsky.social · 21d

Forces at Play: emerging themes in Mechanobiology - In memoriam of Pr. Michael Sheetz,
In Paris, at the Institut Jacques Monod, from January 19th to January 21st 2026.

The registration is now open, and the rates are quite low.

Dead line: end of November

mikeinmemoriam.sciencesconf.org

In memoriam of Prof. Michael P. Sheetz – Forces at Play: emerging themes in Mechanobiology - Sciencesconf.org

mikeinmemoriam.sciencesconf.org

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Benoit Ladoux @bladoux.bsky.social · 21d

www.biorxiv.org/content/10.1...

SCHEPHERD: A universal platform for high-throughput, high-resolution, and programmable control of cell behavior through bioelectric stimulation

Spanning frogs, fish, and humans, direct-current (DC) bioelectric cues play critical roles beyond neuro-muscular function, such as modulating morphogenesis, immune response, and healing through electr...

www.biorxiv.org

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Benoit Ladoux @bladoux.bsky.social · 21d

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...

Regulation of epithelial tissue homeostasis by active trans-epithelial transport

Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...

www.biorxiv.org

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Reposted by Benoit Ladoux

Vincent Lemire @vincent-lemire.bsky.social · Sep 5

⚠️ #Gaza: 83% de civils parmi les tués ; 75% de civils parmi les prisonniers.
• À partir des données de la Direction du Renseignement militaire israélien, @theguardian.com & le magasine israélien
@972mag.com révèlent ces chiffres terrifiants, sans aucune comparaison possible avec d'autres guerres:

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Vincent Lemire @vincent-lemire.bsky.social · 22d

🔥 "Gaza brûle !" annonce fièrement ce matin le ministre de la Défense Israël Katz, qui confirme le début de l'offensive terrestre sur Gaza-ville, avec l'engagement de 2 divisions (environ 30.000 hommes). Quelques données factuelles pour y voir clair, dans le flot des informations du moment:

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Nature @nature.com · 24d

Nature research paper: Energy deficiency selects crowded live epithelial cells for extrusion

go.nature.com/42tmu2l

Energy deficiency selects crowded live epithelial cells for extrusion - Nature

Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.

go.nature.com

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Reposted by Benoit Ladoux

epithelial mechanics fan club @epimechfc.bsky.social · 27d

Hoffmann, L. A., Carenza, L. N., Eckert, J., & Giomi, L. (2022). Theory of defect-mediated morphogenesis. Science advances, 8(15), eabk2712. #EpithelialMechanics
buff.ly/wUYJE0s

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Reposted by Benoit Ladoux

Sara Wickstrom @sarawickstrom.bsky.social · 27d

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Computational image analyst (m/f/d)

The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

jobs.mpi-muenster.mpg.de

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Thibaut Brunet @thibautbrunet.bsky.social · 29d

New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵

Flagellar gliding in choanoflagellates

Freire-Delgado and Brunet discover a new mode of cell motility in choanoflagellates, the closest relatives of animals. Under mild confinement, choanoflagellate move over surfaces without cell deformat...

www.cell.com

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Benoit Ladoux @bladoux.bsky.social · 28d

Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob.
www.biorxiv.org/content/10.1...

The complex microscopic dynamics of cells in high-density epithelial tissues

Epithelial tissues line the surfaces of vital organs and are often densely packed in a disordered, mechanically arrested state, referred to as jammed or glassy state. While collective migration at low...

www.biorxiv.org

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