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Reposted by Sara Wickstrom

Centro Andaluz de Biología del Desarrollo @cabd-upo-csic.bsky.social · 2d

#CABDseminars

"Mechanical regulation of cell states" by Sara Wickström @sarawickstrom.bsky.social, @mpi-muenster.bsky.social

🗓️October 10th
⏰ 12 pm
📍Rosalind Franklin auditorium, CABD

Co-hosted by @dariloops.bsky.social & @jrmarmor.bsky.social

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Reposted by Sara Wickstrom

Journal of Cell Biology @jcb.org · 6d

Join @jcb.org Scientific Editor Gabriele Stephan at the EMBO | EMBL Symposium “Cell biology of the nucleus” during the lunchtime Meet the Editor talk Nov. 19. www.embl.org/about/info/c... #EESNucleus @events.embl.org

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Reposted by Sara Wickstrom

MwahahahahahadScientist @mads100tist.bsky.social · 8d

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

Pathway to Independence: a forecast for the future of developmental biology

ABSTRACT. In 2022, Development launched its Pathway to Independence (PI) programme, aimed at supporting postdocs as they transition to their first independent position. In 2025, we welcome our third c...

journals.biologists.com

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Reposted by Sara Wickstrom

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · 4d

Elegant new study in our journal by @sarawickstrom.bsky.social @katemiro.bsky.social & co!

Nature Cell Biology @natcellbio.nature.com · 4d

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

bit.ly

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Reposted by Sara Wickstrom

Nature Cell Biology @natcellbio.nature.com · 4d

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

bit.ly

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Sara Wickstrom @sarawickstrom.bsky.social · 7d

Thank you Leo!

Sara Wickstrom @sarawickstrom.bsky.social · 7d

Thank you Elias!

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Sara Wickstrom @sarawickstrom.bsky.social · 8d

Thank you for highlighting our paper Daryl! We are very proud of this one too 😊

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Reposted by Sara Wickstrom

Daryl Jason Verzosa David @djdavid.bsky.social · 8d

Third paper to highlight!
Here, Lisa Manning, @sarawickstrom.bsky.social, &c olleagues show contractility, pressure, signalling cooperating in vertebrate development, w/thorough combination of expertise in cell biology, signalling, & biophysics.

(Open Access) www.nature.com/articles/s41...

Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture - Nature Cell Biology

Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis and underlying tissue regulating placode invagination and Sox9 expression.

www.nature.com

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Sara Wickstrom @sarawickstrom.bsky.social · 8d

Thank you Jorge! Nice discussions today 😊

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Reposted by Sara Wickstrom

Journal of Cell Science @jcellsci.bsky.social · 8d

We're still accepting submissions for our next special issue:
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...

#cellbiology #nucleus #notforprofit #freetopublish

Promotional graphic for a special issue of Journal of Cell Science titled 'Cell Biology of the Nucleus.' Guest Editor: Abby Buchwalter. Submission deadline: 3 November 2025. The image features a stylized cell with a bright pink, heart-shaped nucleus on a black background. Text includes a call for papers.

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Sara Wickstrom @sarawickstrom.bsky.social · 8d

Thank you Christian!

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Sara Wickstrom @sarawickstrom.bsky.social · 8d

Thank you Carmelo!

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Reposted by Sara Wickstrom

Carmelo Ferrai @carmeloferrai.bsky.social · 9d

Nice work from the labs of @katemiro.bsky.social @sarawickstrom.bsky.social
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells

www.nature.com/articles/s41...

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Sara Wickstrom @sarawickstrom.bsky.social · 9d

Thank you Adrien!

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Reposted by Sara Wickstrom

Hallou Lab @halloulab.bsky.social · 9d

A landmark study by @sarawickstrom.bsky.social @katemiro.bsky.social and colleagues elucidating the relative contribution of GF and nuclear mechanics on cell fate decisions🤩 !! Many congratulations on this 'tour de force' 👏🎉 (pun on words intended 😉!) !!

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Reposted by Sara Wickstrom

Kaitlin McCreery @mccreery.bsky.social · 9d

Our paper is out in Nature Cell Biology! 🚀 Growth factors, mechanical forces, and osmotic stress work together to guide stem cell differentiation. Delighted to see these discoveries out in the world 🔥

Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Sara Wickstrom @sarawickstrom.bsky.social · 9d

Thank you Francesca!

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Reposted by Sara Wickstrom

Waggoner Lab @labwaggoner.bsky.social · 9d

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells @natcellbio.nature.com @sarawickstrom.bsky.social @akistubb.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

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Sara Wickstrom @sarawickstrom.bsky.social · 9d

Thanks so much Alejo!

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Reposted by Sara Wickstrom

Kurianlab @kurianlab.bsky.social · Sep 8

Many conserved exons in the heart and brain utilize weak 5 ′ splice sites, yet they are accurately spliced. But how? We show that splicing fidelity is actively enforced through a QKI-U6 checkpoint at the U1→U6 handover in essential cardiac genes during organogenesis.
www.biorxiv.org/content/10.1...

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites

During organogenesis, precise pre-mRNA splicing is essential to assemble tissue architecture. Many developmentally essential exons bear weak 5'splice sites (5'SS) yet are spliced with high precision, ...

www.biorxiv.org

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Reposted by Sara Wickstrom

Silvia Fre lab @frelab.bsky.social · 9d

So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social

It just came out online, check it out here:
rdcu.be/eIIKD

Contractile fibroblasts form a transient niche for the branching mammary epithelium

Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...

rdcu.be

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Sara Wickstrom @sarawickstrom.bsky.social · 9d

Thank you Andre! Looking forward to hearing what you think 🤓

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Reposted by Sara Wickstrom

Kate Miroshnikova @katemiro.bsky.social · 9d

Amazing to have our work finally out!!! 😍🤩😍

Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Sara Wickstrom @sarawickstrom.bsky.social · 9d

Indeed! Excited to be discussing this work at CellMech!

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