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Reposted by Kate Miroshnikova

Nature Cell Biology @natcellbio.nature.com · 4d

💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

bit.ly

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Kate Miroshnikova @katemiro.bsky.social · 8d

Thanks Jesse!!!

Kate Miroshnikova @katemiro.bsky.social · 9d

Amazing to have our work finally out!!! 😍🤩😍

Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Reposted by Kate Miroshnikova

Fusion Conferences @fusionconf.bsky.social · 10d

Amy, Leanne, Maria & Kate welcomed our #SCC25 attendees to the beautiful Malta this afternoon, a great 4 days ahead for this group, discussing all things Stem Cells & Cancer!
@joneslabucsf.bsky.social @mariapalcolea.bsky.social @katemiro.bsky.social

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Reposted by Kate Miroshnikova

Edouard Hannezo @ehannezo.bsky.social · Dec 17

Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk

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Reposted by Kate Miroshnikova

Carmelo Ferrai @carmeloferrai.bsky.social · 15d

Paper accepted!!!!
Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊

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Reposted by Kate Miroshnikova

SFB1348 @sfb1348.bsky.social · 28d

Exciting new paper by the group of Carsten Grashoff @sfb1348.bsky.social @uni-muenster.de
shows conformational change in alpha-Catenin during maturation of #epithelial junctions
www.uni-muenster.de/news/view.ph...

How epithelial junctions mature: Study shows conformational transition in key protein

Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof. Carsten Grashoff now provides insight into the molecular details underlying the ...

www.uni-muenster.de

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Reposted by Kate Miroshnikova

Sara Wickstrom @sarawickstrom.bsky.social · 26d

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...

Computational image analyst (m/f/d)

The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

jobs.mpi-muenster.mpg.de

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Reposted by Kate Miroshnikova

Pedro Rocha @pedroprocha.bsky.social · Sep 8

🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...

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Reposted by Kate Miroshnikova

Institut Curie @institutcurie.bsky.social · Sep 4

▶️ Pour en savoir plus
⏩ Lire l'actu : curie.fr/actualite/di...
⏩ Lire la publication : www.nature.com/articles/s41...

DNA methylation influences human centromere positioning and function - Nature Genetics

Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

www.nature.com

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Kate Miroshnikova @katemiro.bsky.social · Sep 3

Would love to be a part of the group if still space! Thanks!

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Reposted by Kate Miroshnikova

Xavier Trepat @xaviertrepat.bsky.social · Sep 1

New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌
@IBECBarcelona
www.biorxiv.org/content/10.1...

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Reposted by Kate Miroshnikova

Jan Lammerding - Lab @lammerdinglab.bsky.social · Aug 29

Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...

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Kate Miroshnikova @katemiro.bsky.social · Aug 18

Thanks so much for the kind words Adrien! 🤩 would love to discuss the next steps to integrate more mechanical measurements as planned soon!

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Reposted by Kate Miroshnikova

Kate Miroshnikova @katemiro.bsky.social · Aug 15

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

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Kate Miroshnikova @katemiro.bsky.social · Aug 15

Thanks so much Martin, hope all is well - would love your feedback!

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Kate Miroshnikova @katemiro.bsky.social · Aug 15

Very proud of this work performed by the super talented Fabien Bertillot with essential support from @sol-herve.bsky.social and our amazing collaborators, especially Toni Seppälä and @sarawickstrom.bsky.social. Grateful for support from @mpi-muenster.bsky.social, NIH, and @helsinki.fi

a woman with a big hairdo is singing and the words simply the best are above her

ALT: a woman with a big hairdo is singing and the words simply the best are above her

media.tenor.com

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Kate Miroshnikova @katemiro.bsky.social · Aug 15

Collectively, our work supports a model where disruption of tissue architecture & stromal cues initiate a co-evolutionary feed forward loop that drives disease aggression & suggests that quantitative analysis of tumor heterogeneity with architecture as proxy may be the key to diagnostic precision

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Kate Miroshnikova @katemiro.bsky.social · Aug 15

Interestingly, while epithelial-to-mesenchymal transition states were also enriched in fragmented architectures, mechanical confinement was not sufficient to trigger #EMT. Combination of compression & soluble signals from the stroma drove further separation of regenerative stem cell and EMT states.

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Kate Miroshnikova @katemiro.bsky.social · Aug 15

To figure out causation we turned to patient derived #organoids. Together with our #bioengineering colleagues in the Lutolf lab we generated topographies that mimic poor prognosis architectures. Indeed, regenerative stem cell states emerged in response to mechanical constraints and compression

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Kate Miroshnikova @katemiro.bsky.social · Aug 15

Analyzing single patient biopsies with heterogeneous architectures showed that cell states and architectures co-evolve, and we can predict likely tissue shape transitions based on the transcriptional signatures! So now the chicken & egg question: which comes first – abnormal shapes or cell states?

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Kate Miroshnikova @katemiro.bsky.social · Aug 15

Intriguingly, nuclear shapes correspond with tissue architectures, both independently predicting patient survival. Overlaying this with #spatialtranscriptomics revealed that fragmented architectures associate with regenerative stem cell states that have been shown to drive metastasis.

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Kate Miroshnikova @katemiro.bsky.social · Aug 15

Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...

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Reposted by Kate Miroshnikova

Hawa Racine Thiam @hawa-racine.bsky.social · Aug 14

A Nuclear Mechanobiology meeting is a dream come true!!! Please join us!

Jan Lammerding - Lab @lammerdinglab.bsky.social · Jul 16

Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!

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Reposted by Kate Miroshnikova

Toby Andrews @tobyandrews.bsky.social · Aug 6

Thrilled to bits to see our latest work online in Dev Cell! 🥳

We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n

tinyurl.com/cell-stretch

Mechanochemical coupling of cell shape and organ function optimizes heart size and contractile efficiency in zebrafish

Andrews et al. demonstrate that multiscale feedback between mechanical and chemical cues builds a functional heart to support zebrafish embryonic life. Cell recruitment and organ-scale forces drive tr...

tinyurl.com

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