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Jan Lammerding - Lab @lammerdinglab.bsky.social · 14d

Registration is still open, and abstracts for posters are still accepted (email me for info or questions)!

Jan Lammerding - Lab @lammerdinglab.bsky.social · 14d

Congratulations!!

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 20d

A big thank you for the GENEROUS support, although general support is good too! :)

Jan Lammerding - Lab @lammerdinglab.bsky.social · 20d

A big Thank You to the general support from the NIH-NHLBI, the Leducq Foundation, the American Heart Association @ahascience.bsky.social, a Fleming Research Fellowship, and the Mills family.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 20d

Expression of a dominant negative nesprin domain, DN KASH, which disrupts the LINC complex, reduces forces on the nucleus, reduces nuclear envelope rupture, and restores expression of many dysregulated genes. DN KASH expression also rescues cardiac function and extends survival by >1 year.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 20d

Detailed transcriptomic analyses indicate that a subset of cardiomyocytes drives disease progression by expression of genes associated with sterile inflammation, likely downstream of nuclear envelope rupture and activation of cytosolic DNA sensors, independent of cGAS/STING.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · 20d

How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.

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Reposted by Jan Lammerding - Lab

Martin Humphries @martinhumphries.bsky.social · Sep 3

Odell, J et al. (@lammerdinglab.bsky.social lab) A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. bioRxiv posted 2 September 2025 doi:10.1101/2025.09.01.673543. www.biorxiv.org/content/10.1...

A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites

Lamins form a dense meshwork at the inner surface of the inner nuclear membrane (INM), where they interact with other nuclear envelope proteins such as emerin. Emerin is an integral membrane protein t...

www.biorxiv.org

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Sep 4

Thanks so much for highlighting our work!

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Aug 30

I should point out that the conference is held in Melbourne, Florida, not Australia!

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Aug 29

Speakers include: @luskinglab.bsky.social @renkawitzteam.bsky.social @pcusachs.bsky.social @gabrielneurohr.bsky.social @simonereber.bsky.social @zierlab.bsky.social @katemiro.bsky.social @sarawickstrom.bsky.social @rashmi-priya.bsky.social @stroudlab.bsky.social @becklab.bsky.social & many more!

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Aug 29

Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...

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Reposted by Jan Lammerding - Lab

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Aug 27

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

Sarafan ChEM-H @stanford-chemh.bsky.social · Aug 26

Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa

Open Faculty Position: Assistant or Associate (Untenured) Professor

Application deadline: 11:55 PM on Wednesday, October 15, 2025

Sarafan ChEM-H is seeking candidates with research programs that exist at the interface between molecular science and computation.

Click the link above to learn more & apply!

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Reposted by Jan Lammerding - Lab

Journal of Cell Biology @jcb.org · Aug 25

FOMO no more: NOMO and Calmin extend #mechanobiology to the ER. Julie Heffler and Jan Lammerding @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) & @hennelab.bsky.social (doi.org/10.1016/j.ce...), in Spotlight: rupress.org/jcb/article/...

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Aug 19

Interested in #mechanobiology of the cell nucleus? The submission deadline for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation.
#MBNSRC

events.faseb.org/event/Mechan...

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Aug 19

Last chance to register and submit an abstract to be considered for a platform presentation. If you are interested in nuclear #mechano Ta

Simone Reber @simonereber.bsky.social · Aug 19

Looking forward to meeting "old" & new friends at the FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.

Submit your abstract by Aug, 31!

Jan Lammerding - Lab @lammerdinglab.bsky.social · Jul 16

Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!

Reposted by Jan Lammerding - Lab

Journal of Cell Biology @jcb.org · Aug 18

Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Aug 18

You are very welcome. It’s been a pleasure reading and highlighting your beautiful work and the evidence you present for how ER tubules are anchored to actin filaments and focal adhesions!

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Aug 14

Please submit your abstracts by August 31st to be considered for a platform presentation! We look forward to an exciting and stimulating meeting! Please share!

Hawa Racine Thiam @hawa-racine.bsky.social · Aug 14

A Nuclear Mechanobiology meeting is a dream come true!!! Please join us!

Jan Lammerding - Lab @lammerdinglab.bsky.social · Jul 16

Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC.
Find more information and register at: events.faseb.org/event/Mechan...
Submit abstracts by August 31, 2025. Please share and see you in October!

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Reposted by Jan Lammerding - Lab

Allen Institute @alleninstitute.org · Aug 8

Happy #FluorescenceFriday! Our #CellLineOfTheWeek is MLC-2a - illuminating sarcomeric thick filaments! 💪🧫

Our high-quality stem cell lines & plasmids are available for just the cost of shipping to reduce the barriers to discovery.

📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social.

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Reposted by Jan Lammerding - Lab

Anne West @ennatsew.bsky.social · Jul 27

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to [email protected].

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Jul 26

…and it provides a better understanding of the normal function of lamins, particular in skeletal and cardiac muscle cells. The work was led by the amazing Jacob Odell and supported by the National Institutes of Health (NIH), National Science Foundation (NSF), and Leducq Foundation.
.

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Jul 26

This effect is due to the unique rod domain of lamin A/C, and does not require the lamin Ig-fold or tail, nor unique binding partners. This work has direct implications for our understanding of how mutations in the LMNA gene cause muscular dystrophy and heart disease…

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Jan Lammerding - Lab @lammerdinglab.bsky.social · Jul 26

What allows lamins A and C to confer much stronger mechanical stability to the nuclei than lamin B? We show that even though all lamins can protect the nucleus from small cell intrinsic forces, only lamin A/C protect the nucleus from large deformations: www.biorxiv.org/content/10.1...
1/n

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Reposted by Jan Lammerding - Lab

Abby Buchwalter @abbybuch.bsky.social · Jul 22

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology

Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...

www.nature.com

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