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Journal of Cell Biology

@jcb.org

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Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press @rupress.org 🌐 https://rupress.org/jcb

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Journal of Cell Biology @jcb.org · Sep 3

Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...

#Reproducibility

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Journal of Cell Biology @jcb.org · 8h

New study from Swift, Pustova, Audhya et al. @uwmadison.bsky.social defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at #endosomes. rupress.org/jcb/article/...

#membrane #lipid

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Journal of Cell Biology @jcb.org · 11h

📣 Don't miss the October 17 deadline! Apply for JCB’s Alan Hall & Norton B. Gilula Travel Awards that support #undergraduates, #gradstudents, and early-career #postdocs to attend #cellbio2025 ✈️ 👉 rupress.org/jcb/pages/al...

Journal of Cell Biology @jcb.org · 1d

SCFFBXO21-mediated ubiquitination and degradation of NMNAT2 regulates axon survival in nerve injury, say Wenjing Long, Yanshan Fang et al.

#Ubiquitin #Neuroscience

Journal of Cell Biology @jcb.org · 2d

Our October issue is out! rupress.org/jcb/issue/22...
The cover shows early postnatal mouse cortex w/ #astrocytes (magenta) & their #mitochondria (green) in a model of inhibited astrocytic mitochondrial fission. See Rodriguez Salazar, @caglaeroglu.bsky.social et al rupress.org/jcb/article/...

Journal of Cell Biology @jcb.org · 2d

LLP1 is a pyrophosphatase involved in homeostasis/quality control of dolichol-linked oligosaccharide, say Sheng-Tao Li, Tadashi Suzuki and colleagues: rupress.org/jcb/article/...

Reposted by Journal of Cell Biology

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 4d

Previously unknown contacts between mitochondria identified using new approach with AI & volumetric electron microscopy

📹 Benjamin S. Padman, Runa S.J. Lindblom & @lazaroulab.bsky.social, @monashuniversity.bsky.social @jcb.org

➡️ bpod.org.uk/archive/2025/10/3 with
@antdlewis.bsky.social

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Journal of Cell Biology @jcb.org · 5d

@kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al show that #macrophages attack adherent cells using #trogocytosis instead of #phagocytosis. Reducing adhesion increased phagocytosis. Mitotic cells, which disassemble adhesions, are more vulnerable to phagocytosis rupress.org/jcb/article/...

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Journal of Cell Biology @jcb.org · 6d

Join @jcb.org Scientific Editor Gabriele Stephan at the EMBO | EMBL Symposium “Cell biology of the nucleus” during the lunchtime Meet the Editor talk Nov. 19. www.embl.org/about/info/c... #EESNucleus @events.embl.org

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Reposted by Journal of Cell Biology

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 7d

Lipid transporter BLTP2 recruitment to ER-plasma membrane contacts controls membrane dynamics

📷 @anbangdai.bsky.social et al @yaleschoolofmed.bsky.social
in @jcb.org

➡️ bpod.org.uk/archive/2025...

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Journal of Cell Biology @jcb.org · 7d

JIP4 and RILPL1 utilize opposing motor force to dynamically regulate lysosomal tubulation, say Luis Bonet-Ponce @lysoluis.bsky.social, Mark R. Cookson @markrcookson.bsky.social and colleagues rupress.org/jcb/article/...

#Organelles #Lysosomes #Trafficking

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Journal of Cell Biology @jcb.org · 7d

Vacuolar pH regulates #clathrin-mediated #endocytosis through #TORC1 signaling during replicative #aging, say Kenneth Gabriel Antenor, Mojca Mattiazzi Usaj et al. @torontometsci.bsky.social rupress.org/jcb/article/...

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Journal of Cell Biology @jcb.org · 8d

Wenjing Long, Yanshan Fang et al reveal that an SCFFBXO21 E3 #ubiquitin ligase complex ubiquitinates NMNAT2 at K155 & promotes its turnover in neurons & show that Fbxo21 deficiency confers axonal protection both in vitro & in vivo rupress.org/jcb/article/...
#Neuroscience

Journal of Cell Biology @jcb.org · 8d

Patterning in motion: Cell interfaces guide mesenchymal collective migration and #morphogenesis. A new perspective from @maikbischoff.bsky.social & @mayorlab.bsky.social rupress.org/jcb/article/...

#CellBio #CellMigration #Development #Science

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Journal of Cell Biology @jcb.org · 8d

All roads lead to TDP43: Convergent mechanisms of TDP43 autoregulation. Morgan Miller & Sami Barmada highlight recent work from Hasegawa-Ogawa and colleagues (rupress.org/jcb/article/...):

rupress.org/jcb/article/...

#Neuroscience #RNAbiology #Neurodegeneration

Journal of Cell Biology @jcb.org · 8d

Galectin-9 regulates #DendriticCell polarity and uropod contraction by modulating RhoA activity, say Guus Franken, Laia Querol Cano et al. rupress.org/jcb/article/...

#CellMigration #Immunology #Immunotherapy

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Journal of Cell Biology @jcb.org · 9d

Dolichol-linked oligosaccharide (DLO) is the precursor for asparagine-linked protein #glycosylation. Sheng-Tao Li, Tadashi Suzuki et al. identify a DLO-pyrophosphatase (Llp1), which is involved in DLO homeostasis/quality control. rupress.org/jcb/article/...

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Journal of Cell Biology @jcb.org · 9d

This collection features tools for rapid vimentin perturbation, studies of single vimentin intermediate filaments, and new findings on the nuclear lamina incl. its interactions w/ telomeres in germ cells or disruptions in the nuclear lamina caused by nuclear aggregates rupress.org/jcb/collecti...

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Journal of Cell Biology @jcb.org · 11d

Rathod, Spindler et al. describe the regulation of desmosomal #adhesion by the mannosyl residue donor DPM1 and the protease inhibitor SERPINB5. rupress.org/jcb/article/...

📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...

Journal of Cell Biology @jcb.org · 11d

Korsten et al. employ live cell imaging and expansion microscopy to show that nuclear polyQ aggregates associated with #HuntingtonDisease induce nuclear envelope (NE) blebbing and cause NE ruptures. rupress.org/jcb/article/...

📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...

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Reposted by Journal of Cell Biology

U-M Life Sciences Institute @umlifesciences.bsky.social · 12d

In a new @jcb.org study, a team of @umich.edu researchers reveal new details in a complex cellular mechanism that is central to the brain’s ability to learn and form memories.

www.lsi.umich.edu/news/2025-09...

Hippocampal neuron with its central cell body, branching neurites and dendritic spines

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Journal of Cell Biology @jcb.org · 12d

Liao et al. @sumaralab.bsky.social show that UBAP2L ensures homeostasis of nuclear pore complexes at the intact nuclear envelope. rupress.org/jcb/article/...

📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...

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Journal of Cell Biology @jcb.org · 12d

@vgelfand.bsky.social et al. use single-particle tracking to show #vimentin intermediate filaments display active movement throughout the cell, w/ individual filaments w/in a bundle moving independently rupress.org/jcb/article/...

📕 Intermediate Filaments collection: rupress.org/jcb/collecti...

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Journal of Cell Biology @jcb.org · 13d

@genehackrman.bsky.social @mattheyseslab.bsky.social

genehackrman.bsky.social

Journal of Cell Biology @jcb.org · 13d

Kowalczyk et al. provide a historical perspective on the discovery of #desmosomes and how imaging technologies have advanced our understanding of this adhesive intercellular junction. rupress.org/jcb/article/...

📕 In our Intermediate Filaments collection: rupress.org/jcb/collecti...

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Journal of Cell Biology @jcb.org · 14d

📢 Do you know any #undergraduates, #gradstudents, or early-career #postdocs looking to attend #CellBio2025? We're now accepting applications for our Travel Awards that could support their participation ✈️
⏰ Deadline: Oct. 17 👉 rupress.org/jcb/pages/al...

@ascbiology.bsky.social