Lightnews — Scholar-powered news

Carmelo Ferrai @carmeloferrai.bsky.social · 8h

@gurdoninstitute.bsky.social

Carmelo Ferrai @carmeloferrai.bsky.social · 21h

Nobel Laureate Professor Sir John Gurdon dies aged 92 cam.ac.uk/research/news/…

Very sad news. A remarkable scientist! He will be always with us.🌻www.cam.ac.uk/research/new...92

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

www.cam.ac.uk

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Carmelo Ferrai @carmeloferrai.bsky.social · 10h

Exactly!

Carmelo Ferrai @carmeloferrai.bsky.social · 12h

Epithelial-mesenchymal transition

www.cell.com/cell/fulltex...

Epithelial-mesenchymal transition

Epithelial-mesenchymal transition (EMT) is a conserved multi-step cellular program that plays an essential role across a range of biological processes. This review covers the roles and states of EMT i...

www.cell.com

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Reposted by Carmelo Ferrai

The Braun Lab @thebraunlab.bsky.social · 11d

This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.

Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin

Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local hetero...

www.biorxiv.org

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Carmelo Ferrai @carmeloferrai.bsky.social · 21h

Nobel Laureate Professor Sir John Gurdon dies aged 92 cam.ac.uk/research/news/…

Very sad news. A remarkable scientist! He will be always with us.🌻www.cam.ac.uk/research/new...92

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

www.cam.ac.uk

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Reposted by Carmelo Ferrai

Ewan Birney @ewanbirney.bsky.social · 7d

In strong agreement- I think the multiple meanings makes using the word a minefield but it is … a widely used word in science and beyond. Plus 1 or 2 intergenerational transmission being different from trans generational (for me 3 or more generations for mammals) is a complex “nuance”

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Carmelo Ferrai @carmeloferrai.bsky.social · 3d

2- I feel that people shouldn’t be annoyed talking about “epigenetics” and a refresh every now an then probably is not bad 🤣 I don’t see any concern to the study of @jamiehackett.bsky.social that indeed is very nice… mainly the fight should point other fronts where epigenetic goes very South!!!👇🏽

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Carmelo Ferrai @carmeloferrai.bsky.social · 3d

1- It’s a terrible word?… certainly periodically triggers some discussion among scientist, which is not bad x se… because it helps (in theory) to align concepts among colleagues. Semantics is a realm often associated to pedantic people… but using words correctly help the discussion. -follows-

scientist.is

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Reposted by Carmelo Ferrai

EMBL @embl.org · 8d

New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development.

These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...

Fathers shape embryonic development through molecular ‘signatures’. Credits: Daniela Velasco/EMBL

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Carmelo Ferrai @carmeloferrai.bsky.social · 4d

I was just wondering how was it possible that discussions on “epigenetics” terminology did’t really light up on BlueSky… but… here U go! So we got a whole package, a beautiful study and a great tread of discussions stemming from it!
All the best to everyone!

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Carmelo Ferrai @carmeloferrai.bsky.social · 4d

Hello @lizebonaaugust.bsky.social very pleased to see it published! That was a fantastic journey which led us to publish a very beautiful story! 👏🏽👏🏽👏🏽👏🏽👏🏽

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Carmelo Ferrai @carmeloferrai.bsky.social · 8d

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Reposted by Carmelo Ferrai

Pombo-GarciaLab @pombo-garcialab.bsky.social · Aug 8

🚨 We are hiring a #postdoc in Quantitative Cell Biology/Biochemistry. Join us if you are interested in using super-resolution STED & cryoET to uncover self-organization dynamics of epithelial cell interfaces & glycobiology collaboration with WuLab
Deadline 31 August
www.nature.com/naturecareer...

Postdoctoral Researcher in Quantitative Cell Biology/Biochemistry (10374) - Harwell, Didcot job with The Rosalind Franklin Institute | 12841894

The Rosalind Franklin Institute (the Franklin) is a technology institute for life science, creating innovative technologies that transform our unde...

www.nature.com

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Reposted by Carmelo Ferrai

Pombo-GarciaLab @pombo-garcialab.bsky.social · Sep 6

🚨 We are hiring a #postdoc in Quantitative Cell Biology/Biochemistry. Join us if you are interested in using super-resolution STED & cryoET to uncover self-organization dynamics of epithelial cell interfaces & glycobiology collaboration with WuLab
zurl.co/aTGq7

About The Rosalind Franklin Institute - Rosalind Franklin Institute

The Rosalind Franklin Institute is a new national institute, announced in 2017 by the UK government, dedicated to bringing about transformative changes in life science through interdisciplinary resear...

zurl.co

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Carmelo Ferrai @carmeloferrai.bsky.social · 8d

👏🏽

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Reposted by Carmelo Ferrai

Shiori Iida @shiori-iida.bsky.social · Aug 29

One more movie!
Using the RL algorithm (from pnas.org/doi/10.1073/...),
@masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility.
Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)

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Reposted by Carmelo Ferrai

Canadian Epigenetics @ceehrc.bsky.social · 8d

FINAL REGISTRATION DEADLINE!

Last day to register for the CEEHRC Annual Meeting is FRIDAY, OCTOBER 10!

Abstracts still being accepted for the poster sessions.

Speaker lineup and other details can be found at event.fourwaves.com/...

#epigenetics #epigenomics #ceehrc

CEEHRC 11th Annual Canadian Conference on Epigenetics

Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics

event.fourwaves.com

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Reposted by Carmelo Ferrai

Journal of Cell Science @jcellsci.bsky.social · 8d

We're still accepting submissions for our next special issue:
Cell Biology of the Nucleus
Guest edited by @abbybuch.bsky.social and Megan King @luskinglab.bsky.social.
Submission deadline: 3 November
journals.biologists.com/jcs/pages/nu...

#cellbiology #nucleus #notforprofit #freetopublish

Promotional graphic for a special issue of Journal of Cell Science titled 'Cell Biology of the Nucleus.' Guest Editor: Abby Buchwalter. Submission deadline: 3 November 2025. The image features a stylized cell with a bright pink, heart-shaped nucleus on a black background. Text includes a call for papers.

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Carmelo Ferrai @carmeloferrai.bsky.social · 8d

Nice work from the labs of @katemiro.bsky.social @sarawickstrom.bsky.social
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells

www.nature.com/articles/s41...

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Carmelo Ferrai @carmeloferrai.bsky.social · 8d

SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence

www.nature.com/articles/s43...

SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence - Nature Cancer

Using mouse pancreatic cancer models, Tsanov et al. show that reactivation of SMAD4 at metastatic sites promotes tumor growth in the lung through RUNX1 but restrains metastatic growth through KLF4 in the liver, influenced by organ-specific epigenetic states.

www.nature.com

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Carmelo Ferrai @carmeloferrai.bsky.social · 9d

💪🏽

Reposted by Carmelo Ferrai

Jan Żylicz @jzylicz.bsky.social · 20d

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

www.biorxiv.org

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Reposted by Carmelo Ferrai

Gurdon Institute, University of Cambridge @gurdoninstitute.bsky.social · 20d

Thrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.

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Reposted by Carmelo Ferrai

Michal Gdula @michal-gdula.bsky.social · May 3

It's been great to have Mike Robson @drmrobson.bsky.social @uam-ibmib.bsky.social - amazing talk, meeting with PhD students & postdocs, hopefully another stop towards tightening of collaboartions between Poznan & Berlin @mdc-berlin.bsky.social! Thanks to #ID-UB for funding! #epiegenetics #LADs

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Reposted by Carmelo Ferrai

Alex Ludwig @alexludwig.bsky.social · Mar 7

We have some exciting news about how epithelial cells initiate an apical lumen de novo, and how this is coordinated with cell-cell junction formation. Check it out: www.biorxiv.org/content/10.1...

Bulk exocytosis of large intracellular apical precursor organelles establishes apical domain identity during de novo lumen formation

The creation of a microvilli-rich apical luminal domain is a key event in the development of epithelial tissues. De novo lumenogenesis, in which epithelial cells establish apical identity by directing...

www.biorxiv.org

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