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Alex Ludwig @alexludwig.bsky.social · 16d

Congrats Sandra!

Reposted by Alex Ludwig

Hans Clevers @hansclevers.bsky.social · Sep 6

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

Epithelial tension controls intestinal cell extrusion

Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

www.science.org

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Reposted by Alex Ludwig

Development @dev-journal.bsky.social · Sep 1

Supracellular actomyosin assemblies: master coordinators of development

In this Review, Katja Röper @katjaroeper.bsky.social discusses supracellular actomyosin structures, tissues where they function, their known roles as well as potential properties

journals.biologists.com/dev/article/...

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Reposted by Alex Ludwig

Kimberly Kline 🏔 @kimingeneva.bsky.social · Aug 11

Our latest efforts to understand Enterococcal wound infection. In long-term collaboration with @gthibault.bsky.social, we discovered how E. faecalis makes extracellular ROS - via EET!⚡️Which in turn dysregulates host UPR to delay wound healing. Led by @aarontan.bsky.social - his videos below are 🤩!

Guillaume Thibault @gthibault.bsky.social · Aug 11

📢 Our new preprint is out! We show how the common gut bacterium 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴 stops wound healing. It uses a metabolic pathway, extracellular electron transport (EET), to stress host cells, halting their migration. Watch WT bacteria (orange) stop the cells while the mutant (blue) doesn't!

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Alex Ludwig @alexludwig.bsky.social · Jul 25

We have some news! We find that the post-synaptic Homer proteins coordinate YAP and Wnt signaling in epithelial cells, downstream of the Crumbs polarity complex. They do so by sequestering YAP and beta-catenin in biomolecular condensates, and by suppressing a FRYL/NDR complex. Check it out!

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · Jul 24

Homer condensates orchestrate YAP-Wnt signaling crosstalk downstream of the Crumbs polarity complex https://www.biorxiv.org/content/10.1101/2025.07.23.666266v1

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Reposted by Alex Ludwig

Felix Campelo @felixmendu.bsky.social · Jul 4

Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio

meetings.embo.org/event/26-org...

Intracellular mechanics and organelle mechanobiology

Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…

meetings.embo.org

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Alex Ludwig @alexludwig.bsky.social · May 18

EMBO Cell Polarity and Membrane Dynamics workshop is off to a good start - as always :) #EMBO

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Reposted by Alex Ludwig

PLOS Biology @plosbiology.org · Apr 14

How are specific cargos targeted to apical & basolateral domains within #EpithelialCells? This study uses a novel #vesicle tracking software "MSP-tracker" to show that the secretory pathway in #Drosophila follicle cells is unexpectedly spatially organized @plosbiology.org 🧪 plos.io/3EfJsBp

A) Diagram of the RUSH system. The Halo-tagged cargo is retained in the ER by the binding of the Streptavidin binding peptide (SBP) to Streptavidin (StrepA), which is fused to the ER retention signal, KDEL. The cargo is synchronously released upon the addition of biotin, which outcompetes SBP for binding to Streptavidin.B) Diagram of the tagged cargo constructs used in this study. C) Steady state expression of UAS-SBP-Halo-Cadherin99c (magenta) under the control of traffic jam-Gal4, showing its localization to the apical microvilli. Phalloidin staining of F-actin (green) labels the apical microvilli in the follicle cells and the oocyte. Scale bar 10 µm. D) Steady state expression of UAS-SBP-SNAP-Ndg (magenta) under the control of traffic jam-Gal4, showing its localization to the basement membrane. Actin is shown in green. Scale bar 10 µm. E) En face view of SBP-SNAP-Ndg in the basement membrane. Scale bar 10 µm. F) Time course of SBP-Halo-Cadherin99C trafficking in fixed samples. G) 25 min after release from the ER, Cad99c (green) localizes to subapical puncta that are labeled by Rab11 (magenta). Scale bar 10 µm. In all figures with a cross-section of the follicle cells, apical is toward the top of the image and basal toward the bottom.

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Alex Ludwig @alexludwig.bsky.social · Apr 17

Entzugserscheinungsangst :)

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Alex Ludwig @alexludwig.bsky.social · Apr 8

Our paper on the regulation of the tight junction leak pathway by Arhgap12/N-Wasp is out ! www.cell.com/cell-reports...

ARHGAP12 suppresses F-actin assembly to control epithelial tight junction mechanics and paracellular leak pathway permeability

Tambrin et al. show that the Cdc42/Rac GAP ARHGAP12 promotes the flux of macromolecules across tight junctions by suppressing junctional actin assembly and tension via N-WASP and the Arp2/3 complex. T...

www.cell.com

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Alex Ludwig @alexludwig.bsky.social · Mar 17

Why am I not surprised…

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Alex Ludwig @alexludwig.bsky.social · Mar 13

journals.biologists.com/jcs/article/...

Science under siege: protecting scientific progress in turbulent times

As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...

journals.biologists.com

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