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Reposted by Michal Gdula

Kate Miroshnikova @katemiro.bsky.social · 9d

Amazing to have our work finally out!!! 😍🤩😍

Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Reposted by Michal Gdula

Piotr Ziolkowski @piotraz.bsky.social · 11d

🚀 We’re hiring a Postdoc!

Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025

🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf

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Alexandria Ocasio-Cortez @aoc.bsky.social · 19d

Disney/ABC have a responsibility to refuse to participate in corruption.

Kimmel must be reinstated. If Disney/ABC agree to this extortion then perhaps creatives + workers should consider collective action to push back. Same w/buying park + cruise tickets if they bow.

People have power. Ask Target

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Ming Tommy Tang @tommytang.bsky.social · 19d

Nature Review: Cis-regulatory elements at cellular resolution
www.nature.com/articles/s4...

Cis-regulatory elements at cellular resolution

Nature Reviews Genetics - In this Comment, the authors outline some key next steps to advance our understanding of cis-regulatory elements at single-cell resolution, which includes harmonizing...

www.nature.com

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Jesse Engreitz @jengreitz.bsky.social · 20d

Excited for a major milestone in our efforts to map enhancers and interpret variants in the human genome:

The E2G Portal! e2g.stanford.edu

This collates our predictions of enhancer-gene regulatory interactions across >1,600 cell types and tissues.

Uses cases 👇

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 19d

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene by the @basvansteensellab.bsky.social

www.science.org/doi/10.1126/...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

www.science.org

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Przemek Grabowicz 🇵🇱🇪🇸🇩🇪🇺🇸🇮🇪 @przemyslslaw.bsky.social · 20d

I'm voting for free speech with my wallet, and cancelling my Disney+ subscription.

max tani @maxtani.bsky.social · 21d

The union representing the musicians from Jimmy Kimmel’s band releases a statement calling the FCC’s pressure on Disney “state censorship.”

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Jesse Engreitz @jengreitz.bsky.social · 20d

New preprint from our lab!

What can we learn about the properties of gene regulatory elements by CRISPR’ing a random set of accessible sites in human cells?

Find out here: www.biorxiv.org/content/10.1...

👇

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bioRxiv - An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq

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Barack Obama @barackobama.bsky.social · 20d

After years of complaining about cancel culture, the current administration has taken it to a new and dangerous level by routinely threatening regulatory action against media companies unless they muzzle or fire reporters and commentators it doesn’t like.

Let’s be clear about what happened to Jimmy Kimmel

Trump’s most brazen attack on free speech yet.

www.yahoo.com

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Michal Gdula @michal-gdula.bsky.social · 20d

Great #EMBOdnatopology meeting in Szklarska Poręba: exciting science, inspiring discussions, and pleased to share our #DNAreplication work! Thanks to Dagmara Jakimowicz, Marcin Szafran & organizers! @embo.org

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Michal Gdula @michal-gdula.bsky.social · 26d

Many great talks at the #E2BRN & #ESDR2025 meeting! Glad to share recent work form my lab on keratinocyte epigenetics and catch up with old friends! Big thanks to Danuta Gutowska-Owsiak
& Ryan O'Shaughnessy for organising #E2BRN! #epigenetics @esdrorg.bsky.social

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Michal Gdula @michal-gdula.bsky.social · 26d

It's been great pleasure to host Takeshi Matsui in Poznan @uam-ibmib.bsky.social
- amazing talk, meeting with PhD students & postdocs, inspiring science discussions! Many thanks to #ID_UB for funding! #epigenetics #epidermalBarier #corneoptosis #E2BRN

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IMBB AMU Poznań @uam-ibmib.bsky.social · Sep 4

Join us on Monday for @UAM_IBMiB
seminar of Takeshi Matsui from the Tokyo University of Technology to learn about keratinocyte-specific cell-death in formation of epidermal barrier! PhD students/postdocs are welcome for the cereer advice meeting! #cellDeath #corneoptosis #ID_UB

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IMBB AMU Poznań @uam-ibmib.bsky.social · Sep 3

🚀🧬 Exciting space science! Yeast engineered with tardigrade genes have been launched to the International Space Station for pioneering experiments by Hanna Kmita's group @uam-ibmib.bsky.social ! Check out the movie for more details! #ISS #tardigrades #space #radiation

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IMBB AMU Poznań @uam-ibmib.bsky.social · Sep 3

Prof. Krzysztof Sobczak , the director of the IBMiB UAM, has been elected to the prestigious group of corresponding members of the Polish Academy of Sciences - congratulations !

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IMBB AMU Poznań @uam-ibmib.bsky.social · Sep 3

Join us this Friday morning @uam-ibmib.bsky.social for the seminar: Prof. Kashmir Singh from the Panjab University, India will give a talk on the role of long Non-Coding RNAs in fungal infections in grapevine! #lncRNA

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IMBB AMU Poznań @uam-ibmib.bsky.social · Sep 3

The teams of @piotraz.bsky.social Ziółkowski from @uam-ibmib.bsky.social and Mikhail Mikhailov discovered that a natural DNA trick triples #recombination in maize! Congratulations to the authors !!! Check out the paper: lnkd.in/dh3QEFSy

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IMBB AMU Poznań @uam-ibmib.bsky.social · Sep 3

Congratulations to Jan Brezovsky form the @uam-ibmib.bsky.social & @iimcb.bsky.social on being recently awarded the @ncn.gov.pl OPUS-LAP research grant! His work on rational design of substrate transporters in bacteria to enhance metabolism promises exciting insights! hashtag#NCNtoTlen

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Peter O'Toole @yorkbioimaging.bsky.social · Aug 26

Money Talks! At least it does for the success of many core facilties. A webinar with Emma Hesketh an me discussing all things around facilities.
www.thermofisher.com/uk/en/home/e...

@thermofishersci.bsky.social #UKTSN @ctlslifescience.bsky.social @rmsearlycareer.bsky.social @abrf.bsky.social

www.thermofisher.com

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Narita Lab @narita-lab.bsky.social · Jul 25

Spread the news! We are excited to expand our research team, working on cellular senescence, at the Cancer Research UK Cambridge Institute, University of Cambridge.

jobs.cam.ac.uk/job/52026/
jobs.cam.ac.uk/job/52027/

a yellow sign that says we 're hiring

ALT: a yellow sign that says we 're hiring

media.tenor.com

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Ming Tommy Tang @tommytang.bsky.social · Jul 24

The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice www.nature.com/articles/s4...

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Evgeny Kvon @evgenykvon.bsky.social · Jul 2

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

Range extender mediates long-distance enhancer activity - Nature

The REX element is associated with long-range enhancer–promoter interactions.

www.nature.com

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IMBB AMU Poznań @uam-ibmib.bsky.social · Jun 25

2nd Polish #RNA Biology Meeting in #Poznan co-organized by @uam-ibmib.bsky.social‬ has started yeaterday evening with talks of Ramesh Pillai & Sebastian Glatt @sebastianglatt.bsky.social‬ - many more great talks, posters & discussions ahead! #PolishRNABiologyMeeting

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Evgeny Kvon @evgenykvon.bsky.social · Jun 23

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

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