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Narita Lab

@narita-lab.bsky.social

710 followers 2.5K following 9 posts

Studying cellular #stress responses, particularly #senescence and its impact on #immune response, #ageing and #cancer, #tumorigenesis at Cancer Research UK CI ‪@cruk-ci.bsky.social‬, University of Cambridge ‪@cam.ac.uk‬ Website: naritalab.com

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Narita Lab @narita-lab.bsky.social · Aug 1

👓 Our latest review is out in the Genes&Dev special issue on Aging and Senescence @genesdev.bsky.social released today: The rise of RAS: how gradual oncogene activation shapes the OIS spectrum genesdev.cshlp.org/content/39/1...
genesdev.cshlp.org/content/curr...

The rise of RAS: how gradual oncogene activation shapes the OIS spectrum

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

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Reposted by Narita Lab

Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 14d

Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇

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Narita Lab @narita-lab.bsky.social · 19d

We are greatly enjoying the exciting science (and location) at ICSA 2025 Rome #ICSA2025Rome @icsasenescence.bsky.social

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Narita Lab @narita-lab.bsky.social · 26d

Tonight, we had a send off dinner for Hiro. We hope you enjoyed your time in our lab and in the UK as much as we enjoyed having you around!

Narita Lab @narita-lab.bsky.social · Sep 8

We were honoured to host Prof. Makoto Nakanishi from the University of Tokyo, presenting his work on the senolytic activity of GLS1 inhibition.

Narita Lab @narita-lab.bsky.social · Aug 21

Dinner with the two summer students we are hosting and who just presented the results of their hard work to the lab 🧪🧫💻

Narita Lab @narita-lab.bsky.social · Aug 20

Introducing Cell Biology to Students from Aichi Prefectural Asahigaoka High School (July 2024 & July 2025)

aichi-asahigaoka.ed.jp/news/-Cjth-tx

Reposted by Narita Lab

Sandra McAllister, PhD @sandramcallister.bsky.social · Aug 14

It’s out!!!!! We hope our review on aging, immunity, and cancer is helpful.

Such a rewarding group effort led by Melissa Dolan, with Kendra Libby, Alison Ringle, and @vangalenlab.bsky.social

So grateful to @gabriellebrewer.bsky.social @natrevcancer.nature.com for her efforts and support

Nature Reviews Cancer @natrevcancer.nature.com · Aug 14

NEW content online!

Ageing, immune fitness and cancer

Nature Reviews Cancer, Published online: 14 August 2025; doi:10.1038/s41568-025-00858-zAgeing reshapes immune composition, function and regenerative capacity, with profound effects on tumour immunity, cancer progression and treatment outcomes. In this Review, Dolan and colleagues examine how age-resolved immunoprofiling, insights from ageing haematopoiesis and preclinical modelling are uncovering immune ageing dynamics and therapeutic challenges — revealing new opportunities to optimize cancer therapy across diverse age groups.

www.nature.com

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Narita Lab @narita-lab.bsky.social · Aug 1

The rise of RAS: how gradual oncogene activation shapes the OIS spectrum

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

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Narita Lab @narita-lab.bsky.social · Jul 29

Only a few days left to apply to join our lab and do exciting senescence research at the University of Cambridge Cancer Research UK Cambridge Institute @cruk-ci.bsky.social @cam.ac.uk 🧪🧬

You can also send informal enquiries (info below):

www.jobs.cam.ac.uk/job/52026/
www.jobs.cam.ac.uk/job/52027/

a cartoon character is surrounded by cats and the caption says when someone asks you what your dream job is

ALT: a cartoon character is surrounded by cats and the caption says when someone asks you what your dream job is

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Nature Biotechnology @natbiotech.nature.com · Jul 22

Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state - @hagentilgner.bsky.social @liganlab.bsky.social go.nature.com/3IKlcJn

Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state - Nature Biotechnology

Joint profiling of chromatin and splicing in the brain uncovers shared and distinct patterns.

go.nature.com

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Reposted by Narita Lab

Mark Peifer (He, him) @peiferlabunc.bsky.social · Jul 26

A recent paper reveals a surprising insight. The length of the cell cycle in a particular tissue determines the oncogenic transformation capacity of particular oncogenes, with tissues with shorter cell cycles most susceptible 3/n

Cell cycle duration determines oncogenic transformation capacity

Danian Chen, Suying Lu, Katherine Huang, Joel D. Pearson, Marek Pacal, Phillipos Peidis, Sean McCurdy, Tao Yu, Monika Sangwan, Angela Nguyen, Philippe P. Monnier, Daniel Schramek, Liang Zhu, David Santamaria, Mariano Barbacid, Nagako Akeno, Kathryn A. Wikenheiser-Brokamp & Rod Bremner

https://www.nature.com/articles/s41586-025-08935-x

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Reposted by Narita Lab

International Cell Senescence Association @icsasenescence.bsky.social · Mar 25

🚨 Big news! The 10th Annual ICSA Meeting is coming to Rome 🇮🇹 on Sept 17-19, 2025!

Join us Sept 16th for the 2nd Phaedon Institute-ICSA SenoTherapeutics Summit!

🎟️ Register now—early bird & abstract submissions close June 15!

🔗 icsa2025rome.com

#ICSARome2025

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Reposted by Narita Lab

Nature Structural & Molecular Biology @natsmb.nature.com · Jul 17

ICYMI: New online: scNanoHi-C2 uncovers dynamic reorganization of 3D chromatin structure in mammalian germ cells

scNanoHi-C2 uncovers dynamic reorganization of 3D chromatin structure in mammalian germ cells

Nature Structural & Molecular Biology, Published online: 16 July 2025; doi:10.1038/s41594-025-01603-8By leveraging long-read sequencing, single-cell input scNanoHi-C2 systematically delineates chromatin structural reprogramming in embryonic-stage germ cells (EGCs), highlighting the functional importance of three-dimensional (3D) genome structure in mammalian EGC development. This method provides a powerful tool for probing chromatin architecture in individual cells, particularly in rare or precious biological samples.

go.nature.com

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Reposted by Narita Lab

Nature Aging @nataging.nature.com · Jul 18

🗞️Our July issue is live!📷 This month, we're featuring work on intrinsic capacity, senescence, and more. Read it all here: www.nature.com/nataging/vol...

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Reposted by Narita Lab

Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Jul 16

🔥NEW paper from our lab! Ever wondered how the metabolite/lipid composition of human bone marrow HSCs changes during differentiation,aging,AML? Check our work www.nature.com/articles/s41... driven by the brilliant Marialena & Maricarmen with Jörg! @mpi-ie.bsky.social @ethz.ch @natcellbio.nature.com

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology

Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

www.nature.com

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Reposted by Narita Lab

Nature Reviews Cancer @natrevcancer.nature.com · Jul 18

#Perspective 🚨
Lazure and Gomes argue that metabolic changes that occur as a result of #ageing may shape tumour initiation and progression and the development of metastatic disease.
⬇️ 📖
https://bit.ly/3IkNY...
@moffittnews.bsky.social‬

Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer

In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.

bit.ly

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Reposted by Narita Lab

Nature @nature.com · Jul 26

Nature research paper: NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity

go.nature.com/3II8HhA

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity - Nature

An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment of myeloid-derived suppressor cells and reinvigorating CD8+ T cell activation.

go.nature.com

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Narita Lab @narita-lab.bsky.social · Jul 25

We are the Narita Lab at Cancer Research UK Cambridge Institute. Excited to join Bluesky and share our research with like-minded scientists!

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Narita Lab @narita-lab.bsky.social · Jul 25

Spread the news! We are excited to expand our research team, working on cellular senescence, at the Cancer Research UK Cambridge Institute, University of Cambridge.

jobs.cam.ac.uk/job/52026/
jobs.cam.ac.uk/job/52027/

a yellow sign that says we 're hiring

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