Nature Aging
@nataging.nature.com
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Nature Aging is a thematic journal from the Nature Portfolio that serves the broad aging research community. Follows & posts ≠ endorsements.
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Nature Aging
@nataging.nature.com
· Sep 8
A blood-based DNA damage signature in patients with Parkinson’s disease is associated with disease progression - Nature Aging
Aging is a risk factor for Parkinson’s disease; however, how DNA damage accumulation, a hallmark of aging, contributes to its pathophysiology remains incompletely understood. Here, the authors identif...
doi.org
Nature Aging
@nataging.nature.com
· Sep 4
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
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Nature Aging
@nataging.nature.com
· Aug 6
Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty - Nature Aging
To better understand the etiology of frailty, the authors perform a large genetic study. They identified 45 additional variants and implicated MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential ca...
doi.org
Nature Aging
@nataging.nature.com
· Aug 4
Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis
Nature Aging - Amyloid fibrils can accumulate in tissues outside the brain, yet the impact is incompletely understood. Here the researchers show that, with age, mouse bone marrow fat cells become...
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Nature Aging
@nataging.nature.com
· Aug 4
Stress granule clearance mediated by V-ATPase-interacting protein NCOA7 mitigates ovarian aging
Nature Aging - The role of cellular stress responses in ovarian aging remains incompletely understood. In this study, the authors identify NCOA7 as a facilitator of autophagic clearance of stress...
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Nature Aging
@nataging.nature.com
· Jul 18
Disease burden, lifetime healthcare cost and long-term intervention impact projections among older adults in Singapore
Nature Aging - Population aging presents challenges for healthcare and social care systems in ensuring that services are available for older adults. Here the authors performed a Singapore-based...
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Nature Aging
@nataging.nature.com
· Jul 16
Associate or Senior Editor, Nature Aging
Title: Associate or Senior Editor, Nature Aging Organization: Nature Portfolio Locations: New York, Jersey City, Shanghai or Beijing – Hybrid Working Model Closing Date: August 20th, 2025 About Spring...
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Nature Aging
@nataging.nature.com
· Jul 15
The GNPC provides a proteomic resource for biomarker discovery and mechanistic insight in neurodegenerative disease - Nature Aging
The Global Neurodegeneration Proteomics Consortium (GNPC) is a multifaceted open-data resource of about 250 million protein measurements for biomarker discovery and mechanistic research across several...
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Reposted by Nature Aging
Nature Aging
@nataging.nature.com
· Jun 11
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease
Nature Aging - Progerin, a truncated version of lamin A, causes Hutchinson–Gilford progeria syndrome characterized by premature aging and cardiovascular complications. Here the authors show...
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Nature Aging
@nataging.nature.com
· Jun 4
Developing a blood-based epigenetic clock for intrinsic capacity - Nature Aging
Intrinsic capacity, the composite of an individual’s physical and mental capacities, is fundamental to healthy aging. Fuentealba and colleagues use DNA methylation data to develop an epigenetic predic...
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Nature Aging
@nataging.nature.com
· Jun 4
A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors - Nature Aging
Fuentealba and colleagues build and validate a DNA methylation clock of intrinsic capacity (IC) to bridge resource-intensive clinical assessments of IC with molecular readouts of aging, highlighting s...
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Nature Aging
@nataging.nature.com
· Jun 4
hUSI is a robust transcriptome-based cellular senescence prediction tool - Nature Aging
Human universal senescence index (hUSI) is a data-driven scoring tool that is derived from the most comprehensive senescence transcriptome data available. Demonstrating excellent accuracy and robustne...
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Nature Aging
@nataging.nature.com
· Jun 4
A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions - Nature Aging
Wang et al. present the human universal senescence index (hUSI), a robust transcriptome-based tool that accurately predicts cellular senescence across diverse conditions, offering insights into aging ...
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Nature Aging
@nataging.nature.com
· Jun 4
Harnessing a noncanonical vestibular input in the head-direction network to rectify age-related navigational deficits - Nature Aging
Hu et al. show an aging-related navigational decline owing to deterioration of the excitatory PVMVN→DTN pathway in the brainstem. Targeted chemogenetic pathway activation in aged mice rectified the de...
doi.org
Nature Aging
@nataging.nature.com
· Jun 4
Aberrant engagement of P-selectin drives hematopoietic stem cell aging in mice - Nature Aging
P-selectin has been considered as a biomarker of hematopoietic stem cell (HSC) aging. Here, Yang et al. uncovered a new functional role of P-selectin engagement in regulating HSC regeneration and driv...
doi.org
Nature Aging
@nataging.nature.com
· Jun 2
The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan - Nature Aging
Gkioni et al. show that trametinib, which targets the Ras–Mek–Erk pathway, extends lifespan in male and female mice and that co-treatment with the known geroprotector rapamycin additively extends life...
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Nature Aging
@nataging.nature.com
· Jun 2
Body-to-brain insulin and Notch signaling regulates memory through neuronal CREB activity - Nature Aging
Zhou, Novak and colleagues identify that the Caenorhabditis elegans hypodermis, a peripheral liver-like metabolic tissue, regulates memory via insulin/IGF-1 and Notch signaling, and show that activati...
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