Nature Aging
@nataging.nature.com
Nature Aging is a thematic journal from the Nature Portfolio that serves the broad aging research community. Follows & posts ≠ endorsements.
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🗞️In our January issue, we celebrate the 5th anniversary of Nature Aging 🎉Read one Q&A from aging researchers, another Q&A to peek behind the scenes at the journal, our reflections on the past 5 years, and lots of great science too, here: nature.com/nataging/vol...
Online now! Study shows LINE-1 is increasingly expressed in mouse hearts with age, its de-repression is accompanied by cGAS-STING activation and cardiac dysfunction, while pharmacological inhibition of LINE-1 or STING improves cardiac function in aged mice. (rdcu.be/e0JU0)
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Targeting age-related LINE-1 activation alleviates cardiac aging - Nature Aging
LINE-1 retrotransposons are implicated in aging, but their role in cardiac aging specifically is not well understood. Here the authors show that LINE-1 expression rises in mouse hearts with age. Genet...
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January 26, 2026 at 9:02 AM
Online now! Study shows LINE-1 is increasingly expressed in mouse hearts with age, its de-repression is accompanied by cGAS-STING activation and cardiac dysfunction, while pharmacological inhibition of LINE-1 or STING improves cardiac function in aged mice. (rdcu.be/e0JU0)
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Online now! Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau181 and P-tau217.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer’s disease - Nature Aging
Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau...
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January 22, 2026 at 12:22 PM
Online now! Kalia et al. investigate metabolic changes in Alzheimer’s disease (AD) using blood metabolomics, and show that lysophosphatidylcholines are associated with early amyloidosis in AD as measured by P-tau181 and P-tau217.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Online now! Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show GRHL2 transactivates CDK19 to inhibit p53-p21 signaling, and demonstrate that GRHL2 gene therapy alleviates age-related urinary dysfunction in mice. (rdcu.be/e0fbZ)
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Reprogramming the GRHL2−CDK19 axis by gene therapy alleviates prostate aging - Nature Aging
The prostate is an important part of the male reproductive system whose aging process is incompletely understood. Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show that...
doi.org
January 22, 2026 at 12:19 PM
Online now! Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show GRHL2 transactivates CDK19 to inhibit p53-p21 signaling, and demonstrate that GRHL2 gene therapy alleviates age-related urinary dysfunction in mice. (rdcu.be/e0fbZ)
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Online now! Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases - Nature Aging
In this technical report Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons. scMORE revealed regulators...
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January 22, 2026 at 12:18 PM
Online now! Ma et al. present scMORE, a polygenic method integrating single-cell multiomics and GWAS to prioritize cell-type-specific, trait-relevant eRegulons.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
🗞️In our January issue, we celebrate the 5th anniversary of Nature Aging 🎉Read one Q&A from aging researchers, another Q&A to peek behind the scenes at the journal, our reflections on the past 5 years, and lots of great science too, here: nature.com/nataging/vol...
January 21, 2026 at 4:28 PM
🗞️In our January issue, we celebrate the 5th anniversary of Nature Aging 🎉Read one Q&A from aging researchers, another Q&A to peek behind the scenes at the journal, our reflections on the past 5 years, and lots of great science too, here: nature.com/nataging/vol...
🗞️Our December issue is live, featuring the identification of age-related cell states in breast cancer on the cover!📷The issue also includes work on ECM aging, somatic mutations, epigenetic drift, intrinsic capacity and much more. Read it all here: nature.com/nataging/vol...
December 15, 2025 at 3:14 PM
🗞️Our December issue is live, featuring the identification of age-related cell states in breast cancer on the cover!📷The issue also includes work on ECM aging, somatic mutations, epigenetic drift, intrinsic capacity and much more. Read it all here: nature.com/nataging/vol...
🗞️Our November issue is live, featuring multilingualism and healthy aging on the cover!📷The issue also includes work on biomarkers of aging, clinical interventions, the interplay between cancer and aging, and much more. Read it all here: www.nature.com/nataging/vol...
November 14, 2025 at 4:05 PM
🗞️Our November issue is live, featuring multilingualism and healthy aging on the cover!📷The issue also includes work on biomarkers of aging, clinical interventions, the interplay between cancer and aging, and much more. Read it all here: www.nature.com/nataging/vol...
Online now! Emily Shuldiner et al. show that in mice, aging represses KRAS-driven lung tumorigenesis and dampens the impact of inactivating many tumor suppressor genes
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression - Nature Aging
The mechanisms that impact tumorigenesis during aging are incompletely understood. Here Shuldiner et al. show that in mice, aging represses KRAS-driven lung tumorigenesis and dampens the impact of ina...
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November 5, 2025 at 10:10 AM
Online now! Emily Shuldiner et al. show that in mice, aging represses KRAS-driven lung tumorigenesis and dampens the impact of inactivating many tumor suppressor genes
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Online now! @binyammogessie.bsky.social, @jiyeonleem.bsky.social and colleagues provide a system that enables cohesion protein depletion in mouse oocytes, probing reproductive age-related egg aneuploidy.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy - Nature Aging
To study pathways that lead to aneuploidy during aging, the authors provide a system that enables cohesion protein depletion in mouse oocytes, mimicking effects that occur during aging. They uncover a...
doi.org
November 5, 2025 at 10:06 AM
Online now! @binyammogessie.bsky.social, @jiyeonleem.bsky.social and colleagues provide a system that enables cohesion protein depletion in mouse oocytes, probing reproductive age-related egg aneuploidy.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Online now! A new study shows that hospital-treated infectious diseases have a lasting impact on the development of epilepsy in older age, and that cardiovascular risk factors may exacerbate this impact.
doi.org/10.1038/s435...
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Hospital-treated infectious diseases and the risk of epilepsy in older age - Nature Aging
Infectious diseases can cause acute seizures. Here the authors investigate their long-term impact on the risk of epilepsy for older adults. They find that hospital-treated infectious diseases have a l...
doi.org
November 5, 2025 at 10:02 AM
Online now! A new study shows that hospital-treated infectious diseases have a lasting impact on the development of epilepsy in older age, and that cardiovascular risk factors may exacerbate this impact.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Online now!✨Parsons et al profile age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer nature.com/articles/s43... rdcu.be/eOc8t @vangalenlab.bsky.social @sandramcallister.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
Cell populations in human breast cancers are molecularly and biologically distinct with age - Nature Aging
Parsons and colleagues characterize age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer using computational analysis of transcriptomic ...
nature.com
November 4, 2025 at 11:21 AM
Online now!✨Parsons et al profile age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer nature.com/articles/s43... rdcu.be/eOc8t @vangalenlab.bsky.social @sandramcallister.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social
Online now! In their study, Ezuz et al. show that the aged spleen contributes to T cell aging through hemolytic stress in a heme- and iron-rich microenvironment.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Heme and iron toxicity in the aged spleen impairs T cell immunity through iron deprivation - Nature Aging
In their study, Ezuz et al. show that the aged spleen contributes to T cell aging through hemolytic stress and an increasingly heme- and iron-rich microenvironment. T cells adapt by limiting their iro...
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October 20, 2025 at 7:45 AM
Online now! In their study, Ezuz et al. show that the aged spleen contributes to T cell aging through hemolytic stress in a heme- and iron-rich microenvironment.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Genomic study of brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and phys health, and suggests high blood pressure and T2D as causal factors of brain aging #brainage @pjawinski.bsky.social @humboldtuni.bsky.social @mpicbs.bsky.social www.nature.com/articles/s43...
Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health - Nature Aging
This genomic study of magnetic resonance imaging-based brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and physical health, and suggests high blood pressure and type...
www.nature.com
October 16, 2025 at 3:49 PM
Genomic study of brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and phys health, and suggests high blood pressure and T2D as causal factors of brain aging #brainage @pjawinski.bsky.social @humboldtuni.bsky.social @mpicbs.bsky.social www.nature.com/articles/s43...
In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...
Targeting iron-associated protein Ftl1 in the brain of old mice improves age-related cognitive impairment - Nature Aging
The authors identify ferritin light chain 1 (FTL1), an iron-associated protein, as a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain impro...
www.nature.com
October 16, 2025 at 3:42 PM
In our October issue: Ferritin light chain 1 (FTL1), an iron-associated protein, is a pro-aging neuronal factor that increases with age and promotes cognitive decline. Targeting FTL1 in the brain improved cognition in old mice @VilledaLab @ucsfaging.bsky.social @UCSF www.nature.com/articles/s43...
🗞️Our October issue is live!📷This month, we're featuring work on regulators of cognitive decline, senescence – immune interplay, herb-derived geroprotectors and more. Read it all here: nature.com/nataging/vol...
October 16, 2025 at 3:14 PM
🗞️Our October issue is live!📷This month, we're featuring work on regulators of cognitive decline, senescence – immune interplay, herb-derived geroprotectors and more. Read it all here: nature.com/nataging/vol...
Online now! A new study shows that degraded elastin fragments, which increase in the circulation over time, promote aging. Counteracting elastin fragment signals alleviates inflammation, promotes healthy aging, and extends lifespan. (rdcu.be/eITno) doi.org/10.1038/s435...
Elastin-derived extracellular matrix fragments drive aging through innate immune activation
Nature Aging - The contribution of the extracellular matrix and its degradation to the aging process is not well understood. Here, the authors show that degraded elastin fragments, which increase...
rdcu.be
September 30, 2025 at 3:59 PM
Online now! A new study shows that degraded elastin fragments, which increase in the circulation over time, promote aging. Counteracting elastin fragment signals alleviates inflammation, promotes healthy aging, and extends lifespan. (rdcu.be/eITno) doi.org/10.1038/s435...
🗞️Our September issue is live!📷This month, we're featuring work on somatic mutations, clocks, and more. Read it all here: nature.com/nataging/vol...
September 18, 2025 at 5:10 AM
🗞️Our September issue is live!📷This month, we're featuring work on somatic mutations, clocks, and more. Read it all here: nature.com/nataging/vol...
Online now! In this Perspective members of the Aging Biomarker Consortium (ABC) outline the X-Age project, an ABC plan for building standardized aging clocks in China. (rdcu.be/eGFV0)
doi.org/10.1038/s435...
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The X-Age Project to construct a Chinese aging clock
Nature Aging - In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The...
rdcu.be
September 16, 2025 at 11:41 AM
Online now! In this Perspective members of the Aging Biomarker Consortium (ABC) outline the X-Age project, an ABC plan for building standardized aging clocks in China. (rdcu.be/eGFV0)
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Online now! Study identifies a blood-based DNA damage signature in Parkinson’s disease patients that associates with disease progression. (rdcu.be/eES51)
doi.org/10.1038/s435...
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A blood-based DNA damage signature in patients with Parkinson’s disease is associated with disease progression - Nature Aging
Aging is a risk factor for Parkinson’s disease; however, how DNA damage accumulation, a hallmark of aging, contributes to its pathophysiology remains incompletely understood. Here, the authors identif...
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September 8, 2025 at 8:11 AM
Online now! Study identifies a blood-based DNA damage signature in Parkinson’s disease patients that associates with disease progression. (rdcu.be/eES51)
doi.org/10.1038/s435...
doi.org/10.1038/s435...
🎉 We’re thrilled to present our August issue, which includes a Focus on immune aging! 🎉Here, you’ll find a series of reviews and opinion pieces on recent advances in immune aging research nature.com/nataging/vol... 🎨by Alex Whitworth
September 4, 2025 at 1:32 PM
🎉 We’re thrilled to present our August issue, which includes a Focus on immune aging! 🎉Here, you’ll find a series of reviews and opinion pieces on recent advances in immune aging research nature.com/nataging/vol... 🎨by Alex Whitworth
Online now! @thevilchezlab.bsky.social @sedakoyuncu.bsky.social identify age-related hyperactivation of EPS8/RAC signaling in C.elegans as a driver of pathological protein aggregation, highlighting EPS8 and its regulators as potential therapeutic targets.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
www.nature.com
September 4, 2025 at 11:01 AM
Online now! @thevilchezlab.bsky.social @sedakoyuncu.bsky.social identify age-related hyperactivation of EPS8/RAC signaling in C.elegans as a driver of pathological protein aggregation, highlighting EPS8 and its regulators as potential therapeutic targets.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Online now! A genetic study of frailty identifies 45 additional variants and implicates MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism, and cellular signaling.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty - Nature Aging
To better understand the etiology of frailty, the authors perform a large genetic study. They identified 45 additional variants and implicated MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential ca...
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August 6, 2025 at 8:47 AM
Online now! A genetic study of frailty identifies 45 additional variants and implicates MET, CHST9, ILRUN, APOE, CGREF1 and PPP6C as potential causal genes, linking frailty to immune regulation, metabolism, and cellular signaling.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Online now! A new study shows that with age bone marrow fat cells become senescent and secrete SAP/PTX2, driving amyloid buildup and bone loss. (rdcu.be/ezbVV)
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis
Nature Aging - Amyloid fibrils can accumulate in tissues outside the brain, yet the impact is incompletely understood. Here the researchers show that, with age, mouse bone marrow fat cells become...
rdcu.be
August 4, 2025 at 3:14 PM
Online now! A new study shows that with age bone marrow fat cells become senescent and secrete SAP/PTX2, driving amyloid buildup and bone loss. (rdcu.be/ezbVV)
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Online now! Study identifies NCOA7 as a facilitator of autophagic clearance of stress granules in granulosa cells, thereby protecting against ovarian aging. Loss of NCOA7 promotes ovarian aging, while its expression delays aging. (rdcu.be/ezbT4)
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Stress granule clearance mediated by V-ATPase-interacting protein NCOA7 mitigates ovarian aging
Nature Aging - The role of cellular stress responses in ovarian aging remains incompletely understood. In this study, the authors identify NCOA7 as a facilitator of autophagic clearance of stress...
rdcu.be
August 4, 2025 at 3:13 PM
Online now! Study identifies NCOA7 as a facilitator of autophagic clearance of stress granules in granulosa cells, thereby protecting against ovarian aging. Loss of NCOA7 promotes ovarian aging, while its expression delays aging. (rdcu.be/ezbT4)
doi.org/10.1038/s435...
doi.org/10.1038/s435...
🗞️Our July issue is live!📷 This month, we're featuring work on intrinsic capacity, senescence, and more. Read it all here: www.nature.com/nataging/vol...
July 18, 2025 at 11:09 AM
🗞️Our July issue is live!📷 This month, we're featuring work on intrinsic capacity, senescence, and more. Read it all here: www.nature.com/nataging/vol...