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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · 26d

Thanks for your visit and the awesome talk!!:))

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Aug 21

Thanks @adlunglab.com for sharing!:)

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Reposted by Nina Cabezas-Wallscheid

Lorenz Adlung Lab @adlunglab.com · Aug 20

Ageing & leukemia reshape metabolism of hematopoietic stem and progenitor cells. Mapping lipidomic and metabolomic shifts in human bone marrow, spotlighting choline as a key player in stemness to restore physiology!
@natcellbio.nature.com @ninacabezas.bsky.social
doi.org/10.1038/s415... 🧪

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells

Nature Cell Biology - Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia,...

doi.org

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Reposted by Nina Cabezas-Wallscheid

Nature Cell Biology @natcellbio.nature.com · Aug 13

🍹 @ninacabezas.bsky.social & co combine #metabolomics, #lipidomics and transcriptomics of #hematopoietic stem and progenitor cells during differentiation, #aging and #leukemia, finding a role for choline and showing that supplementation enhances stemness.
bit.ly/3H98V0U

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology

Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

bit.ly

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Jul 28

So cool! A Podcast of our work! Thanks for the highlight :)

Stem Cell Podcast @stemcellpodcast.com · Jul 28

This week: the #metabolomics of HSPCs!

A new @natcellbio.nature.com study from Drs. Marialena Lalioti, Mari Carmen Romero-Mulero, Joerg Buescher, and @ninacabezas.bsky.social identifies metabolic changes that occur with differentiation, aging, and #AML.

📝- go.nature.com/4kOZVLX
🎧- bit.ly/3IGfUP1

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Reposted by Nina Cabezas-Wallscheid

Nature Cell Biology @natcellbio.nature.com · Jul 28

🗞️Do you want to meet and chat with our stem cell editor @slefkopoulos.bsky.social about your work for our journal? He will be there!
Register now for the FEBS Workshop on Aging in Hematopoiesis that will take place in Crete on October 20-24. aginginhematopoiesis2025.febsevents.org

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Jul 19

Thank you very much Stelios!!:))

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Reposted by Nina Cabezas-Wallscheid

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Jul 18

🥂Congratulations to @ninacabezas.bsky.social & co for their new study in @natcellbio.nature.com combining #metabolomics, #lipidomics and transcriptomics of #hematopoietic stem and progenitor cells during differentiation, aging and leukemia.
bit.ly/40rfNx3

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology

Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

bit.ly

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Reposted by Nina Cabezas-Wallscheid

Vijay G. Sankaran @bloodgenes.bsky.social · Jul 16

Really valuable resource in @natcellbio.nature.com from @ninacabezas.bsky.social and team - Metabolomic and lipidomic profiling of human hematopoietic stem and progenitor cells:

www.nature.com/articles/s41...

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology

Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

www.nature.com

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Jul 17

Thank you Vijay!!!! Highly appreciated:)))

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Reposted by Nina Cabezas-Wallscheid

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Jul 15

The first comprehensive map of HSC metabolism. 😱

The team of @ninacabezas.bsky.social published the first integrated map detailing metabolic & molecular changes in human blood stem cells as they age, specialize, or turn cancerous with many astonishing insights

More in @natcellbio.nature.com or ⬇️

Mapping the metabolism of blood stem cells

Researchers at the Max Planck Institute of Immunobiology and Epigenetics and ETH Zurich have created the first comprehensive metabolic profile of human blood stem cells. This opens up new possibilitie...

www.ie-freiburg.mpg.de

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Jul 16

Here our press release :)) www.ie-freiburg.mpg.de/6049881/news... thanks Marcus!!

Mapping the metabolism of blood stem cells

Researchers at the Max Planck Institute of Immunobiology and Epigenetics and ETH Zurich have created the first comprehensive metabolic profile of human blood stem cells. This opens up new possibilitie...

www.ie-freiburg.mpg.de

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Jul 16

BIG THANKS to the amazing collaborations that made this study possible!

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Jul 16

We developed two novel low-input metabolomics&lipidomics methods(3K&5K cells)to tackle these questions! Among our findings: dietary-derived choline plays a key role in regulating the stemness of both young and aged HSCs!

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Jul 16

🔥NEW paper from our lab! Ever wondered how the metabolite/lipid composition of human bone marrow HSCs changes during differentiation,aging,AML? Check our work www.nature.com/articles/s41... driven by the brilliant Marialena & Maricarmen with Jörg! @mpi-ie.bsky.social @ethz.ch @natcellbio.nature.com

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology

Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

www.nature.com

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Reposted by Nina Cabezas-Wallscheid

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Jul 11

Wow. 🥳 The recent cardio paper by @ninacabezas.bsky.social lab got 2️⃣ beautiful highlights.

… one by Nature Cardiovascular Research nature.com/articles/s44...
and a second review by Science Immunology
science.org/doi/10.1126/...

Congratulations to team for this fantastic recognition! 🥇🥈

A vitamin A metabolite can regulate the activity of hematopoietic stem cells and thereby reduce inflammation after a heart attack, ultimately improving heart function in the long term.

© Artist: Youssef Youssef

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Jul 11

👏🏻👏🏻👏🏻

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Jul 11

Wow. 🥳 The recent cardio paper by @ninacabezas.bsky.social lab got 2️⃣ beautiful highlights.

… one by Nature Cardiovascular Research nature.com/articles/s44...
and a second review by Science Immunology
science.org/doi/10.1126/...

Congratulations to team for this fantastic recognition! 🥇🥈

Nina Cabezas-Wallscheid @ninacabezas.bsky.social · Jun 14

:)))

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Reposted by Nina Cabezas-Wallscheid

Marlies Vanden Bempt @marliesvandenbempt.bsky.social · Jun 14

Full house for the keynote talk of @ninacabezas.bsky.social in the 2nd #YERM session of today 😍 She shared some intriguing insights on the role of Vitamin A in HSCs!

#EHA2025 #youngEHA

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Reposted by Nina Cabezas-Wallscheid

Dominic Grün @dominicgrun.bsky.social · Jun 11

Consider attending the MOPITAS autumn school on Spatial Transcriptomics in Munich with expert lectures and hands-on sessions for all steps of spatial transcriptomics data analysis.
event.sdu.dk/mopitas-scho...

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Reposted by Nina Cabezas-Wallscheid

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Jun 7

Traveling to the @isscr.org meeting in HK soon? Feeling like browsing through important #StemCell work published during the past year on your way there? Take a look at our collection of papers published across @natureportfolio.nature.com during the past 12 months!

www.nature.com/collections/...

A year of stem cell and developmental biology

In recent years, the field of stem cell and developmental biology has seen remarkable breakthroughs that have deepened our understanding of how organisms ...

www.nature.com

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · May 26

Get well very soon Stelios! :( 💪🏻

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Reposted by Nina Cabezas-Wallscheid

Jesús Rafael RODRIGUEZ-AGUILERA @harry-brennan.bsky.social · May 9

A very inspiring and motivating coffee with Dr. @ninacabezas.bsky.social! Thank you very much for your time and for the excellent talk on the regulation of hematopoietic stem cell dormancy at @cbm-csic-uam.bsky.social

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Nina Cabezas-Wallscheid @ninacabezas.bsky.social · May 5

Massive congraaaaats to Julian on an awesome PhD defense (with honors)!!! :)) Couldn’t be prouder — incredible job and so well earned!!!🥳👏🏻😎 @mpi-ie.bsky.social @sgbmfreiburg.bsky.social @cibss.bsky.social

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Reposted by Nina Cabezas-Wallscheid

Nature Cell Biology @natcellbio.nature.com · Apr 27

☕@ninacabezas.bsky.social, Heidt & co show that 4-oxo-retinoic acid promotes #cardiac recovery after myocardial infarction by modulating #hematopoietic stem cells. #preclinical
bit.ly/4iXb2Cx

Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction: a preclinical study - Nature Cell Biology

Rettkowski, Romero-Mulero et al. show that myocardial infarction impacts bone marrow haematopoietic stem cells and leads to inflammatory myelopoiesis, which can be dampened by treatment with 4-oxo-ret...

bit.ly

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