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Alexis Verger 🧬🧫🧪

@alexis-verger.cpesr.fr

4.7K followers 940 following 1.5K posts

Molecular & structural biologist CNRS with a big respect for Transcription Factors, RNA Pol II & Mediator #CryoEM #ESR Advocating for #basicresearch #womeninSTEM #preprint Message in English or French. https://bsi-lille.cnrs.fr

bsi-lille.cnrs.fr

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Apr 23

Our last contribution is now available.

The first #CryoEM structure of a Mediator subunit (MED23) in complex with the transactivation domain of Elk-1. Unstructured TAD of course, and to spice things up, it's phosphorylation dependent.

www.nature.com/articles/s41...

Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1 - Nature Communications

The Mediator complex subunit MED23 contributes to transcriptional activation by the phosphorylated transcription factor Elk-1, in response to Ras-MAPK signalling. Here, the authors determine a cryo-EM...

www.nature.com

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 2h

Petite blague d'un collègue que je partage : "Dans trois 1er Ministre c'est Noël" 😁

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 5h

Pour célébrer le prix nobel de chimie, si on réécoutait @nanoporous.net sur @franceculture.fr en 2019 nous parler de ces fameuses structures métallo-organiques poreuses (MOFs)

www.radiofrance.fr/francecultur...

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Reposted by Alexis Verger 🧬🧫🧪

The New York Times @nytimes.com · 1d

Fred Ramsdell was parked at a campground in Montana on Monday when his wife suddenly started shouting. He first thought that maybe she had seen a grizzly bear. Instead, she had regained cell service and had seen a flood of text messages with the same news. “You just won the Nobel Prize!” she yelled.

Winning a Nobel Prize Interrupted His Off-the-Grid Vacation

Fred Ramsdell found out about his Nobel Prize nearly 12 hours after it was announced because he was on vacation in the Rockies.

nyti.ms

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 5h

#nobelprize bon ba ça fait 1 👩 et 8 👨pour les sciences, c'est toujours mieux que l'année dernière....

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 6h

enjoy this moment 🥂, in 2026 biology will be back for the #chemnobel 🥳 😋

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 6h

C'est @nanoporous.net qui va être content #chemnobel #MOFs

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 8h

#chemnobel 🍿

www.youtube.com/live/0d02ONE...

Announcement of the 2025 Nobel Prize in Chemistry

YouTube video by Nobel Prize

www.youtube.com

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Reposted by Alexis Verger 🧬🧫🧪

Sheila Teves @sheilateves.bsky.social · 20h

How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.

Read it here 👉

www.biorxiv.org/content/10.1...

#MolecularEvolution #Transcription

Molecular determinants underlying functional divergence of TBP homologs

The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...

www.biorxiv.org

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 12h

#groundhogday

Ils sont donc tous en train de s'écharper par plateau de télé et presse interposés à donner un spectacle pitoyable et pendant ce temps là le RN compte les points.

Le RN n'a même pas besoin de programme ou de personnes qui tiennent la route, tous les autres font le boulot pour eux 😭🤮

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 22h

En juin 2024 ? 😬

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 22h

Comme disait un collègue, avec LR=RN, c'est simple en fait, ça se réduit à anti-RN contre RN, faut juste que ce qui reste des macronistes choisissent leur camp 😬

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 22h

On va essayer mais putain ça se rapproche de plus en plus 😅

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 23h

J'ai Rdv à la mairie, j'ai des enveloppes à déposer 😬

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 23h

🍿

Le Canard enchaîné @lecanardenchaine.fr · 1d

En cas d'échec des ultimes négociations de Lecornu, Macron préférera toujours la dissolution à la démission. Les préfets ont déjà reçu la consigne officieuse de se tenir prêts pour de nouvelles législatives les 16 et 23 novembre.

Démission de Sébastien Lecornu : Emmanuel Macron, acculé à la dissolution ? | Le Canard enchaîné

Après la chute du gouvernement Lecornu, le Président est désormais lâché par ses ex-Premiers ministres, à commencer par Edouard Phillippe et Gabriel Attal.…

www.lecanardenchaine.fr

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 1d

Et la situation politique pour 64% des PhD aux US 😬

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Reposted by Alexis Verger 🧬🧫🧪

James Briscoe @jamesbriscoe.bsky.social · 1d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 1d

My prediction also 😬
bsky.app/profile/alex...

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 14d

It's soon #Nobelprize week !

My 2 cents 2025 prediction

#mednobel J. Bloch & G. Courtine for restoring function after spinal cord injury

#chemnobel S. Balasubramanian, D. Klenerman & P. Mayer for NGS

#physnobel J. Navarro, C. Frenk & S. White for Dark matter

#Literaturenobel M. Atwood

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 1d

#chemnobel

2004 Ubiquitin
2006 RNA Pol II
2007 GFP
2009 Ribosome
2012 GPCR
2014 Palm STORM
2015 DNA repair
2017 CryoEM
2020 CRISPR
2024 AlphaFold

😬🍾😊😬

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 1d

Will chemists be happy tomorrow 🍾, or will they say, “Here we go again with biology” 😡 for the Nobel Prize in Chemistry? #chemnobel 😬

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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 1d

LLPS 😬

Reposted by Alexis Verger 🧬🧫🧪

1000WomeninSTEM @1000womeninstem.bsky.social · 1d

8️⃣8️⃣ Frances Oldham Kelsey (1914-2015) 🇨🇦 #womeninSTEM Canadian pharmacologist and physician, FDA expert who refused marketing authorization for thalidomide in the USA because she felt its safety had not been demonstrated.

thecanadianencyclopedia.ca/en/article/f...