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Jan Żylicz

@jzylicz.bsky.social

600 followers 180 following 23 posts

Group Leader in epigenetic and metabolic regulation of early development 🇪🇺🏳️‍🌈 https://renew.ku.dk/research/zylicz_group/

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Jan Żylicz @jzylicz.bsky.social · 20d

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

www.biorxiv.org

Reposted by Jan Żylicz

kuba sędziński @kuba-sedzinski.bsky.social · 16d

🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x

Jan Żylicz @jzylicz.bsky.social · 20d

🙏 A. Wenzel, K. Uściło, S. Kompocholi, S. Bages-Arnal,
@gemnov.bsky.social

Jan Żylicz @jzylicz.bsky.social · 20d

Using HDAC3 knockout embryos, we show that they typically fail to implant, and if they manage, they are very small and upregulate the most active genes. It is fascinating how a repressor of enhancers regulates the most active genes, allowing for development and to proceed.

Jan Żylicz @jzylicz.bsky.social · 20d

At enhancers HDAC3 fights with P300, an activator, to reduce the expression of the most active fraction of the genome. Losing HDAC3 boosts the levels of pluripotency and prevents them from efficiently differentiating.

Jan Żylicz @jzylicz.bsky.social · 20d

We found that HDAC3, a histone deacetylase, is an intriguing transcriptional repressor. Rather than maintaining genes in a silent state, it is recruited to the most active enhancers of mouse pluripotent stem cells.

Jan Żylicz @jzylicz.bsky.social · 20d

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

www.biorxiv.org

Jan Żylicz @jzylicz.bsky.social · Jul 15

It’s always a bit awkward to write about personal experiences. I tried to touch on what Pride means to me and ended up reflecting on heteronormativity, passing, and allyship. Thank you @slefkopoulos.bsky.social for the great opportunity! @ucph.bsky.social
#LGBTQIA+ #PRIDE #Diversity

Nature Cell Biology @natcellbio.nature.com · Jul 14

🏳️‍🌈Our editor @slefkopoulos.bsky.social discussed with @jzylicz.bsky.social about the importance of celebrating Pride, representation in science, and more! Happy Pride!
Read here: rdcu.be/ewfba
bit.ly/3Uc72TO

Coming out is not a one-time event - Nature Cell Biology

June is the month celebrating Pride in the USA and other countries around the world to honour the Stonewall Uprising of 1969, as well as all progress and current strives claiming equal justice for mem...

Jan Żylicz @jzylicz.bsky.social · Jul 7

There is still some time to secure your spot at the next Niche meeting in CPH. We have a great lineup of speakers! @novo-nordisk.bsky.social sciencecluster.dk/event/confer...

Jan Żylicz @jzylicz.bsky.social · Jun 27

I could not have been more proud! The first student from the lab just defended his PhD in great style!! Congratulations Arnau Casòliba Melich !!! A huge thank you to the committee @bernasozen.bsky.social Ana Boskovic and @aramariaceleste.bsky.social

Jan Żylicz @jzylicz.bsky.social · Jun 18

Wow huge congratulations!

Jan Żylicz @jzylicz.bsky.social · Jun 17

It was fun to chat with @amjeve.bsky.social about my fantastic mentors and how it is to become independent at reNEW_Global @ucph.bsky.social

Development @dev-journal.bsky.social · Jun 17

Transitions in development – an interview with Jan Żylicz

We met with @jzylicz.bsky.social‬ (reNEW @ucph.bsky.social) on Teams to learn more about working abroad, finding a good mentor and his career path so far:
journals.biologists.com/dev/article/...

Photo of Jan Żylicz

Reposted by Jan Żylicz

Nature Cell Biology @natcellbio.nature.com · May 9

💫NEW: @jzylicz.bsky.social & co show that dimethyl α-ketoglutarate enhances the production and functional maturation of human #trophectoderm - like cells from embryonic #StemCells by regulating histone acetyltransferase activity and the pluripotency network.
bit.ly/3EGflmL

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells - Nature Cell Biology

Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...

Jan Żylicz @jzylicz.bsky.social · Apr 29

We also find that there is robust reductive glutamine metabolism in stem cells with glutamine becoming the most prominent source of carbon for histone acetylation

Jan Żylicz @jzylicz.bsky.social · Apr 29

Pyruvate emerged as a vital metabolic nexus in pluripotent stem cells, with high pyruvate carboxylase and malic enzyme activity. Functionally, this is crucial for the timely exit from naive pluripotency and maintaining histone acetylation levels.

Jan Żylicz @jzylicz.bsky.social · Apr 29

We used 13C labeling and imaging MS to uncover how metabolism rewires when the mouse embryo implants. We found that there is no simple TCA cycle shutdown; rather, there is intricate rewiring. This process is recapitulated in pluripotent stem cells cultured under low oxygen.

Jan Żylicz @jzylicz.bsky.social · Apr 29

In a new preprint with @trabelink.bsky.social, T. Moritz & @bonalditiziana.bsky.social, we find that implantation leads to rewiring of the TCA cycle to support histone acetylation turnover and exit from naïve pluripotency. Gr8 work of @elenikafkia.bsky.social D. Pladevall-Morera et al. rb.gy/clk8vm

TCA cycle rewiring underpins implantation and histone acetylation programming

Metabolism has emerged as a key regulator of stem cell differentiation and their epigenomes. This coupling is particularly evident during the exit from naive pluripotency in vitro. However, our unders...

Jan Żylicz @jzylicz.bsky.social · Apr 24

This was a great collaboration lead by Karlien Van Nerum with @sophiepetropoulos.bsky.social ThomasMoritz and EpiQMax.

Jan Żylicz @jzylicz.bsky.social · Apr 24

Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. rb.gy/spqr9j
@natcellbio.nature.com

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells - Nature Cell Biology

Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...

Jan Żylicz @jzylicz.bsky.social · Mar 27

Become Our New Faculty Colleague! We are looking for a junior Principal Investigator to expand their stem cell research towards translational outcomes.
reNEW Copenhagen @ucph.bsky.social
#stemcell #diversity #faculty #regenerativemedicine shorturl.at/m9Zko

Junior Group Leader (Associate Professor) in Stem Cell Medicine

Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW Department of Biomedical Sciences Faculty of Health and Medical Sciences University of Copenhagen &

Jan Żylicz @jzylicz.bsky.social · Mar 24

It was very fun to contribute to this article: "But genes are not the whole story. New research has shown the extent to which cell metabolism (...) has an important, underappreciated role in directing cell fates". www.quantamagazine.org/how-metaboli... QuantaMagazine @ucph.bsky.social

How Metabolism Can Shape Cells’ Destinies | Quanta Magazine

A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.

www.quantamagazine.org

Jan Żylicz @jzylicz.bsky.social · Mar 3

Only 2 weeks left to apply! 16 fantastic positions available, also @ucph.bsky.social . For our project remember to apply both at shorturl.at/yf7Qq & nuclear-dn.eu.

Jan Żylicz @jzylicz.bsky.social · Feb 7

We're hiring a motivated PhD student! Join reNEW @ucph.bsky.social & @nucleardn.bsky.social to study how metabolism regulates chromatin & stem cell fate thanks to generous Marie Skłodowska-Curie Fellowship. Remember to apply both at shorturl.at/yf7Qq & nuclear-dn.eu.

Jan Żylicz @jzylicz.bsky.social · Feb 7

The grass is always greener on the other side. But for now Denmark is a pretty nice place to live and do research! We mainly complain about the weather.

Jan Żylicz @jzylicz.bsky.social · Jan 21

I’m very excited about this collaborative project! We managed to significantly scale up and streamline human blastoid generation without the use of feeders. @leeboratory.bsky.social @grazianomartello.bsky.social @pasquelab.bsky.social and Nicolas Rivron @ucph.bsky.social

Graziano Martello @grazianomartello.bsky.social · Jan 21

With pleasure we share our preprint reporting robust and cost-effective expansion of naive human Pluripotent Stem Cells without feeder cells. A fantastic collaborative effort with @leeboratory.bsky.social @jzylicz.bsky.social @pasquelab.bsky.social and Nicolas Rivron.

tinyurl.com/5n6z9rt9

Jan Żylicz @jzylicz.bsky.social · Dec 3

Congratulations!!! This is great news!!