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Reposted by The Braun Lab

Rob Klose @robklose.bsky.social · 11h

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!

jobs.jic.ac.uk/Details.asp?...

John Innes Centre

jobs.jic.ac.uk

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Reposted by The Braun Lab

James Briscoe @jamesbriscoe.bsky.social · 1d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Reposted by The Braun Lab

Camille Moore @camille-moore.bsky.social · 5d

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes

Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

www.science.org

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The Braun Lab @thebraunlab.bsky.social · 11d

This work was only possible thanks to a fantastic collaboration with Bassem Al-Sady, Ilya Finkelstein, Junko Kanoh, and Mo Motamedi. 🙌
We’re also deeply grateful for all the insightful feedback from the community at #Pombe2025 and support from @jlugiessen.bsky.social
@lmumuenchen.bsky.social
(7/n)

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The Braun Lab @thebraunlab.bsky.social · 11d

Together, these findings reframe subtelomeric heterochromatin as a dynamic, modular system rather than a uniform domain. They highlight how genome structure and epigenetic diversity intersect at chromosome ends, with implications from yeast to humans. (6/n)

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The Braun Lab @thebraunlab.bsky.social · 11d

We also discovered that subtelomeric silencing has distinct genetic requirements, more similar to heterochromatin formed in euchromatic contexts. Strikingly, even within a single subtelomere, different loci depend on different sets of factors. (5/n)

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The Braun Lab @thebraunlab.bsky.social · 11d

#Silencing behaviors were equally diverse. Some loci showed stable recovery after perturbation, others switched ON <-> OFF in a metastable manner, while fragile sites lost repression irreversibly. Structural variation of chromosomal arms further shaped these #epigenetic outcomes. (4/n)

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The Braun Lab @thebraunlab.bsky.social · 11d

Our results reveal that subtelomeric heterochromatin is not one continuous spreading domain but instead organized into modular subdomains. Telomere-proximal regions rely on #RNAi and #shelterin, while distal regions nucleate through #cryptic RNA-based sites. (3/n)

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The Braun Lab @thebraunlab.bsky.social · 11d

To overcome these challenges, we engineered strains carrying a single subtelomere and inserted #single-cell reporters at defined positions. This allowed us to follow silencing dynamics in unprecedented detail across multiple generations. (2/n)

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The Braun Lab @thebraunlab.bsky.social · 11d

We set out to understand how subtelomeric #heterochromatin is organized in #Spombe. Subtelomeres are repetitive, variable, and poorly mapped, yet play essential roles in protecting chromosome ends and regulating genome function. (1/n)

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The Braun Lab @thebraunlab.bsky.social · 11d

This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1....
This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.

Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin

Subtelomeres are imperfect repeats adjacent to telomeres that are repressed by heterochromatin. Although essential for genome integrity, their repetitive nature has thwarted dissection of local hetero...

www.biorxiv.org

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Reposted by The Braun Lab

Gesellschaft für Genetik @gfgenetik.bsky.social · 12d

Amazing 2. day at the GfG ‘Epigenetics & Chromatin’ symposium. Fantastic flash talks, a great first poster session and many memorable talks: among others @erhardtlab.bsky.social, @rodvilla.bsky.social, @thebraunlab.bsky.social, @flurylab.bsky.social, Ehrenhofer-Murray, Liefke, Heun, Imhof & Brehm.

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Reposted by The Braun Lab

Gesellschaft für Genetik @gfgenetik.bsky.social · 14d

What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!

Juri Kazakevych @juri-epigenomics.bsky.social · 14d

Looking forward to exciting talks at the GfG Symposium in Gießen.

Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud

#epigenomics @diagenode.bsky.social @gfgenetik.bsky.social

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The Braun Lab @thebraunlab.bsky.social · 27d

Congrats to this impressive work!

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Reposted by The Braun Lab

The Groth lab @grothlab.bsky.social · Aug 28

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Image of Niels Mejlgaar (CEO of DNRF), Anja Groth (EpiC director) & Jesper Fisker (CEO of DCS).

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Reposted by The Braun Lab

Sandra Hake @hake-chromatin.bsky.social · Aug 25

Excited to share our newest results on ZNF512B: It not only regulates chromatin organization, binds NuRD and H2A.Z, and acts as transcriptional repressor (Wunderlich et al., NAR, 2024), it also participates in mitosis and is crucial for stem cell differentiation.
www.biorxiv.org/content/10.1...

ZNF512B associates with mitotic spindles, regulates metaphase exit and is crucial for stem cell differentiation

Zinc finger proteins are a large family of DNA-binding factors that play key roles in diverse cellular processes including gene regulation, RNA metabolism and cell cycle control. The zinc finger prote...

www.biorxiv.org

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Reposted by The Braun Lab

Sandra Hake @hake-chromatin.bsky.social · Aug 19

Congratulations, Dr. Kalita!!!

Gesellschaft für Genetik @gfgenetik.bsky.social · Aug 19

Dr. Agata Kalita wins the prestigious GfG Elisabeth-Gateff Prize 2025 for her amazing work on sex chromosome dosage compensation in insects!
Dr. Kalita will receive the award at the upcoming GfG Symposium “Epigenetics & Chromatin” on September 26th, 2025 (express.converia.de/frontend/ind...).

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The Braun Lab @thebraunlab.bsky.social · Aug 16

Farewell to guest student Rosario Brockhausen (Constructor Univ. Bremen) 🎉 . In just 2 months she made big strides, key manuscript contributions & was a wonderful colleague. Hope to see her back soon! 👋

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Epigenome Technologies @epigenometech.bsky.social · Aug 4

Epigenetics Update - The molecular basis of lamin-specific chromatin interactions go.nature.com/3GRXydB

Chiara Lanzuolo (INGM) and Ohad Medalia (University of Zurich) reporting in NSMB

#Epigenetics #Chromatin #Lamin
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Gain deeper insights into gene regulation; epigenometech.com

The molecular basis of lamin-specific chromatin interactions - Nature Structural & Molecular Biology

Wang, Kronenberg-Tenga, Rosti and colleagues use several structural approaches to analyze the distribution of nucleosomes at the lamin–chromatin interface, test the impact of lamins on nucleosome dens...

go.nature.com

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Reposted by The Braun Lab

RTG 2355 @rtg2355.bsky.social · Jul 21

New paper out by RTG2355 members Jennifer Kothe, Theresa Dietz, Robina Scheuer & Elena Evguenieva-Hackenberg, identifying a new attenuation mechanism that apparently monitors ribosome availability and translation efficiency in the soil bacterium Sinorhizobium meliloti

Early posttranscriptional response to tetracycline exposure in a gram-negative soil bacterium reveals unexpected attenuation mechanism of a DUF1127 gene

The gram-negative, soil-dwelling plant symbiont Sinorhizobium meliloti shares its free-living habitat with antibiotic producers. To learn about early steps of its adaptation to antibiotics, we anal...

www.tandfonline.com

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Reposted by The Braun Lab

Abby Buchwalter @abbybuch.bsky.social · Jul 21

The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n)
www.molbiolcell.org/doi/10.1091/...

Lamin B1 and LAP2β resist cytoskeletal force to maintain lamin A/C meshwork organization and preserve nuclear integrity | Molecular Biology of the Cell

The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. ...

www.molbiolcell.org

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Reposted by The Braun Lab

Markus Landthaler @landthalerm.bsky.social · Jul 22

www.cell.com/cell/fulltex...

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress

SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

www.cell.com

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The Braun Lab @thebraunlab.bsky.social · Jul 24

Exciting paper on how the nuclear envelope talks to chromatin!

Abby Buchwalter @abbybuch.bsky.social · Jul 22

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology

Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to h...

www.nature.com

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The Braun Lab @thebraunlab.bsky.social · Jul 24

Congrats Abby! Exciting! Glad to see this out!

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Reposted by The Braun Lab

Teif lab @teiflab.bsky.social · Jan 14

Here is a growing list of conferences and schools in gene regulation for 2025 generegulation.org/conferences-.... You can order/filter this list by the date, deadline, location. Please reply here to suggest new events*

*should be specific to gene regulation

Conferences & Schools – 2025 – Gene Regulation – Teif Lab

generegulation.org

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