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Reposted by Rob Klose

Aydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · 1h

Our PhD call is open, take a look! (we are not recruiting this round)

Max Planck Institute for Molecular Genetics @molgen.mpg.de · 18h

🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences.
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...

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Rob Klose @robklose.bsky.social · 11h

Thanks Duncan, that’s very kind.

Reposted by Rob Klose

Maxim Greenberg @maxvcg.bsky.social · 16h

I'm glad that most academic institutions are on Bluesky now, so we can get the press releases I used to love on Twitter that are like "Congratulations to this year's Nobel Prize winner _______, who once used our third-floor bathroom."

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Reposted by Rob Klose

Aleksander Szczurek @aleksszczurek.bsky.social · 21h

If you are a computational biologist come, apply and join Howard & Klose lab in a joint Norwich-Oxford collaboration on chromatin dynamics!

John Innes Centre @johninnescentre.bsky.social · 2d

VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system.

www.jic.ac.uk/vacancies/po...

Closing date - 9 November 2025
Salary - £37,500 - £45,350
Contract - 36 months, full-time

Postdoctoral Researcher (Howard Group) | John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.

www.jic.ac.uk

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Reposted by Rob Klose

Alex de Mendoza @alexdemendoza.bsky.social · 19h

Thrilled to share that the lab has been awarded a @wellcometrust.bsky.social Discovery Award to keep exploring the evolution of 6-methyladenine #6mA in Eukaryotes. We'll open postdoc (3️⃣) and tech (1️⃣) positions to start in 2026, please share with candidates or reach out if you’d like to join us.

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Reposted by Rob Klose

Emilia Dimitrova @edimitrova.bsky.social · 2d

If you are a computational biologist interested in how chromatin states are established and maintained to regulate transcription, this is the dream job for you! This will be in close collaboration with the Klose lab in Oxford and we have a lot of cool projects you can get involved in. Apply!

John Innes Centre @johninnescentre.bsky.social · 2d

VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system.

www.jic.ac.uk/vacancies/po...

Closing date - 9 November 2025
Salary - £37,500 - £45,350
Contract - 36 months, full-time

Postdoctoral Researcher (Howard Group) | John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.

www.jic.ac.uk

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Reposted by Rob Klose

Ander Movilla @andermovilla.bsky.social · 2d

Very exciting opportunity for those with a quantitative background and interested in epigenetics / gene regulation. Highly collaborative environment!

John Innes Centre @johninnescentre.bsky.social · 2d

VACANCY - We have an opportunity for a Postdoctoral Researcher to join the Howard Group, working to develop computational models of epigenetic dynamics in the Polycomb system.

www.jic.ac.uk/vacancies/po...

Closing date - 9 November 2025
Salary - £37,500 - £45,350
Contract - 36 months, full-time

Postdoctoral Researcher (Howard Group) | John Innes Centre

An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology.

www.jic.ac.uk

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Rob Klose @robklose.bsky.social · 22h

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!

jobs.jic.ac.uk/Details.asp?...

John Innes Centre

jobs.jic.ac.uk

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Rob Klose @robklose.bsky.social · 22h

Me too!

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Reposted by Rob Klose

Laurence Pearl 🔥 @laurencepearl.bsky.social · 23h

I’m going for NextGen DNA sequencing

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Reposted by Rob Klose

Prachee Avasthi @pracheeac.bsky.social · 1d

Some scientists aren’t waiting for journals to catch up. They’re showing us what’s next.

The Beyond the Journal awards honor those breaking the mold in how science is shared.

More details: pracheeac.substack.com/p/off-roadin...

Nominate or self-nominate here: www.experiment.foundation/beyond

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Reposted by Rob Klose

James Briscoe @jamesbriscoe.bsky.social · 1d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Reposted by Rob Klose

Edda Schulz @eddaschulz.bsky.social · 2d

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial

Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology

Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

www.nature.com

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Reposted by Rob Klose

Laurence Pearl 🔥 @laurencepearl.bsky.social · 2d

If it’s for liquid-phase separation as a major mechanism in cellular organisation, they will hear me scream all the way over in Stockholm

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Reposted by Rob Klose

Laurence Pearl 🔥 @laurencepearl.bsky.social · 3d

A lot of hype appearing that the scientifically illiterate concept of liquid-phase separation as a significant factor in cellular organisation will get a Nobel Prize this year.

Glad my career is over.

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Rob Klose @robklose.bsky.social · 4d

Exactly

Reposted by Rob Klose

John Greally @greally.bsky.social · 4d

Ooooh, now we disagree! That proposal only really works if the underlying ambiguity is clarified explicitly ("epigenetics" = each of the following).

In which case, why not leave out the word #epigenetics and just, you know, explain what you mean? It's what humans do with language.

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Reposted by Rob Klose

Mikhail Spivakov @mspivakov.bsky.social · 5d

Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.

In a new preprint, we share some clues about when, how, and why this happens!

www.biorxiv.org/content/10.1...

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency

In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associate...

www.biorxiv.org

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Reposted by Rob Klose

Alfredo Castello @alf-castello.bsky.social · 5d

Are you thinking on an exciting PHD project at the interface of translation control and innate immunity? @rnanomad.bsky.social and I have a project that might interest you!

Mehdi Jafarnejad @rnanomad.bsky.social · 5d

@alf-castello.bsky.social & I are inviting applications for a competitive PhD studentship to study the mechanisms of translational regulation of the host response to RNA virus infections. The student will be based at Uni. Glasgow. Please spread the word. #RNASky

www.gla.ac.uk/postgraduate...

University of Glasgow - Postgraduate study - Centres for Doctoral Training - NorthWest Biosciences - Our Projects - Understanding Pathogens, from Molecules to Phenotypes - Alfredo Castello

www.gla.ac.uk

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Rob Klose @robklose.bsky.social · 6d

Congratulations Aydan!

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Reposted by Rob Klose

Aydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · 6d

7 year labiversary of our lab! Now with a new set of young researchers. Proud of what we’ve achieved and excited about the future.

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Reposted by Rob Klose

Syma Khalid @sykhalid.bsky.social · 8d

Come join us in Oxford! Two positions open right now in @oxfordbiochemistry.bsky.social
It’s a great place to work. Really supportive colleagues, great students, colleges provide a unique social environment - in summary, it’s a lot of fun.

Tobias Warnecke @tobiaswarnecke.bsky.social · 9d

Become my colleague @oxfordbiochemistry.bsky.social !
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism

my.corehr.com/pls/uoxrecru...

Job Details

my.corehr.com

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Reposted by Rob Klose

Lucas Farnung @lucas.farnunglab.com · 9d

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

Protein Domain Designer tool for the generation of publication-ready protein domain diagrams

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Reposted by Rob Klose

Tobias Warnecke @tobiaswarnecke.bsky.social · 9d

Become my colleague @oxfordbiochemistry.bsky.social !
2 Associate Professorships in the areas of
- prokaryotic/eukaryotic microbiology
- metabolism

my.corehr.com/pls/uoxrecru...

Job Details

my.corehr.com

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Reposted by Rob Klose

Lori Passmore @lapassmore.bsky.social · 11d

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

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