Author summary In host cells, RNA-binding proteins play essential roles in the life cycle of many viruses by influencing how viral RNA is processed, translated, replicated and assembled into virions. ...

We built and characterised a mass spectrometer capable of performing CID (both beam type and resonant type), UVPD, EID and ECD in an automated fashion during an LCMS type experiment. We exploited this...

The type I interferon (IFN-I) response shapes the intracellular environment to supress virus infection. Historically, this remodelling has been linked to the transcriptional induction of interferon st...

N-Hydroxysuccinimide (NHS) ester chemistry is used extensively across proteomics sample preparation. One of its increasingly prevalent applications is in isobaric reagent-based quantitation such as iT...

Translation of mRNA into protein is a fundamental process and tightly controlled during development, however, experimentally controlling the mRNA translation remains challenging. Here, the authors dem...

RNA binding protein combinations control neuronal identity through a network of temporal regulators.

Cell Death & Disease - Why Bax detection in >1400 publications might be flawed

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

PhD Project - Antiviral defence during early development at University of Edinburgh, listed on FindAPhD.com

Kamel et al. apply complementary approaches to elucidate the composition of Sindbis virus ribonucleoproteins. They identified a subset of nuclear proteins that selectively translocate to the cytoplasm, interact with viral RNA, and suppress virus infection. Among them, U2 snRNP emerges as a ribonucleoprotein complex with moonlighting antiviral activity.

Abstract. Ribosome quality control (RQC) resolves collided ribosomes, thus preventing their cytotoxic effects. The chemotherapeutic agent 5-Fluorouracil (5