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Sara MaciasRNA @saramaciasrna.bsky.social · Jun 2

In our last preprint we identify endogenous dsRNAs capable of activating the interferon response. Could these be relevant to our understanding of DiGeorge syndrome (22qDS)?

In collaboration with @herassr.bsky.social and @heick.bsky.social labs

www.biorxiv.org/content/10.1...

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8

The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...

www.biorxiv.org

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Reposted by Sara MaciasRNA

William Garland @willgarland.bsky.social · Jun 2

Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social

www.biorxiv.org/content/10.1...

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8

The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...

www.biorxiv.org

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Reposted by Sara MaciasRNA

The Francis Crick Institute @crick.ac.uk · May 12

As tighter immigration policies are announced today, scientists continue to stress the importance of attracting international talent.

Our director Paul Nurse spoke to the Observer about how this affects science in the UK:

observer.co.uk/news/politic...

Is the UK paying the price for world’s most expensive visas? | The Observer

Competing political and economic goals on immigration are resulting in the loss of valuable skills and talent in the UK

observer.co.uk

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Reposted by Sara MaciasRNA

Sara R Heras @herassr.bsky.social · Mar 27

Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...

DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects

Abstract. The 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 2

academic.oup.com

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Sara MaciasRNA @saramaciasrna.bsky.social · Mar 27

Our last paper in collaboration with Sara RHeras is finally out 🥳we modelled Dgcr8 haploinsufficiency in hESCs and exciting differences between 🧘🏽‍♂️and 🐭 at the transposon and miRNA content -HERVH & C19MC
Thanks to all the coauthors and funders

academic.oup.com/nar/article/...

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Sara MaciasRNA @saramaciasrna.bsky.social · Feb 6

Thanks for visiting 🌻

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Reposted by Sara MaciasRNA

Sandra Blanco Lab @sblancolab.bsky.social · Jan 25

I'm so excited about @saramaciasrna.bsky.social invitation to visit the Institute of Immunology and Infection Research, @edinburgh-uni.bsky.social on the 5th of February. I will be sharing our latest research on #RNAmodifications in #cancer

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Sara MaciasRNA @saramaciasrna.bsky.social · Dec 7

Congrats!

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Sara MaciasRNA @saramaciasrna.bsky.social · Dec 2

RECRUITING-PhD student to study the role of RNA-binding proteins in antiviral defence during early development.
#crispr #iclip #omics
Interested candidates, please email a full CV and a statement of interest. Open to both UK and overseas

www.findaphd.com/phds/project...

Antiviral defence during early development at University of Edinburgh on FindAPhD.com

PhD Project - Antiviral defence during early development at University of Edinburgh, listed on FindAPhD.com

www.findaphd.com

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Sara MaciasRNA @saramaciasrna.bsky.social · Dec 1

Important reading - unfortunately not open access

Johanna Joyce @johannajoyce.bsky.social · Nov 25

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
🧵 1/

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Reposted by Sara MaciasRNA

Institute of Molecular Biology (IMB) @imbmainz.bsky.social · Nov 28

And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬

More details via www.imb.de/jobs
Application deadline is 5 January 2025

#sciencejobs #resilience #biostatistics

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Sara MaciasRNA @saramaciasrna.bsky.social · Nov 28

Had an amazing time visiting King’s college dept of Infectious diseases. Thanks @Rocio Nunez and @Hannah Mischo for the hosting and great tapas with @charlotte odendall

…and a beautiful early morning walk by the river!

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Reposted by Sara MaciasRNA

Michelle Percharde @mpercharde.bsky.social · Nov 26

Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)

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Reposted by Sara MaciasRNA

Quintana Lab @juanquintana.bsky.social · Nov 27

#Immunosky #neuroskyence our team is expanding and we’re recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...

www.jobs.manchester.ac.uk

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Sara MaciasRNA @saramaciasrna.bsky.social · Nov 22

This is so good! Thanks @tillysscott.bsky.social

Tilly S Scott @tillysscott.bsky.social · Nov 21

And with that the afternoon of @gensocuk.bsky.social short talks is done! We've had: 1) KRABs binding L2/MIR elements, which would effect cardiovascular development; 2) DGCR8 prevents the accumulation of TE-made double-stranded RNA; 1/3 🧵

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Sara MaciasRNA @saramaciasrna.bsky.social · Nov 22

Thank you 🌻

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Sara MaciasRNA @saramaciasrna.bsky.social · Nov 22

Thank you! It was great to hear about your work on the mechanisms of pre-eclampsia!

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Sara MaciasRNA @saramaciasrna.bsky.social · Nov 21

Great discussion at the Genetics Society conference 🧬

Genetics Society UK @gensocuk.bsky.social · Nov 21

Next up is @SaraMaciasRNA
discussing how DGCR8 acts as a gatekeeper of the interferon response by preventing cytoplasmic TE-dsRNA accumulation #GStransposons

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Sara MaciasRNA @saramaciasrna.bsky.social · Nov 21

Could I please be included? Thanks 😊

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Reposted by Sara MaciasRNA

Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · Nov 20

Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
Then come join me & @juanquintana.bsky.social at
@lydiabeckeriii.bsky.social as a
research assistant
Email to arrange
an informal chat 🧪 #ImmunoSky #LGBTQSTEM www.jobs.manchester.ac.uk/Job/JobDetai...

Research Assistant in Tissue Immunology:Oxford Road

www.jobs.manchester.ac.uk

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Sara MaciasRNA @saramaciasrna.bsky.social · Nov 20

Me toooooo

Sara MaciasRNA @saramaciasrna.bsky.social · Nov 20

You coming too!!!! Fun fun dun

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Sara MaciasRNA @saramaciasrna.bsky.social · Nov 20

On our way to the Genetics Society meeting at Leicester. We cannot wait to hear all about transposable elements 🧬 with my friend and collaborator Sara R Heras (soon joining this network too 😂)

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Sara MaciasRNA @saramaciasrna.bsky.social · Nov 19

See you there 😊

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Sara MaciasRNA @saramaciasrna.bsky.social · Nov 18

New EdiRNA events for the new year! Funded by the @RNASociety. Great opportunity to network with other RNA biologists 🧬 (dsRNA included) from Edinburgh and beyond 🚀
Jan 29, 2025
Apr 9, 2025
Jun 11, 2025
Oct TBD, 2025

www.edirna.com/meetings

EVENTS | EdiRNA

ediRNA aims to establish new collaborations, encourage scientific discussion, and enhance interactions between RNA researchers across Edinburgh.

www.edirna.com

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