Lightnews — Scholar-powered news

William Garland @willgarland.bsky.social · 21d

How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens.
www.biorxiv.org/content/10.1...

Molecular basis of polyadenylated RNA fate determination in the nucleus

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs, that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, including prote...

www.biorxiv.org

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William Garland @willgarland.bsky.social · 28d

Registration and abstract submission is open for the 10th annual Danish RNA Society meeting 🇩🇰 - this year in Aarhus!
Deadline is October 1st
danish-rna-society.nemtilmeld.dk/8/

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William Garland @willgarland.bsky.social · Jul 22

Postdoc positions available in the THJ group in Aarhus, Denmark 🇩🇰

Please share around 🤝

Torben Heick Jensen @heick.bsky.social · Jun 27

Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...

A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

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William Garland @willgarland.bsky.social · Jul 3

Happy to share our latest collaboration with the Cusack and Kadlec groups—now published in @natsmb.nature.com
Combining cryo-EM, structure-guided mutants & proximity labeling, we show how PHAX, CBC, CRM1 & Ran‑GTP assemble the snRNA export complex
Article: rdcu.be/euC4U
News & Views: rdcu.be/euC5l

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Reposted by William Garland

Torben Heick Jensen @heick.bsky.social · Jun 27

Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...

A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

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William Garland @willgarland.bsky.social · Jun 19

Spotlight: shorturl.at/E6je8

Article: shorturl.at/cJsDG

shorturl.at

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William Garland @willgarland.bsky.social · Jun 19

We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social.

Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.

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William Garland @willgarland.bsky.social · Jun 17

mbg.au.dk/en/news-and-...

International recognition for Aarhus researchers: RNA science takes off

RNA research in Aarhus is taking a significant leap forward. Two researchers from the same department and research environment have both just been awarded one of Europe’s most prestigious research gra...

mbg.au.dk

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William Garland @willgarland.bsky.social · Jun 2

Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social

www.biorxiv.org/content/10.1...

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8

The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon...

www.biorxiv.org

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William Garland @willgarland.bsky.social · Apr 28

I've been wanting to try something like this. Awesome to see that it works 👍

Román González-Prieto @romangp.bsky.social · Apr 28

New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome.

www.biorxiv.org/content/10.1...

PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow.

Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...

www.biorxiv.org

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Reposted by William Garland

albinsan.bsky.social @albinsan.bsky.social · Apr 7

Very proud to share this work just out in NAR: spearheaded by @jamieauxillos.bsky.social and Arnauld Stigliani: TLDR-seq, a method for 5’ to 3’ end long-read sequencing of capped RNAs regardless of 3’ end polyadenylation, based on the @nanoporetech.com platform. (1/4) tinyurl.com/3c2ksdmr

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Reposted by William Garland

Torben Heick Jensen @heick.bsky.social · Feb 20

PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk

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Reposted by William Garland

AlphaFold Unofficial @alphafold.bsky.social · Feb 20

“Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans.

AI co-scientist is a collaborative tool to help experts gather research and refine their work”

blog.google/feed/google-...

We’re launching a new AI system for scientists.

Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans. Researchers…

blog.google

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Reposted by William Garland

Leopold Parts @leopoldparts.bsky.social · Jan 31

We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church.
www.science.org/doi/10.1126/...

Randomizing the human genome by engineering recombination between repeat elements

We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...

www.science.org

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William Garland @willgarland.bsky.social · Feb 7

New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology
@molbiolau.bsky.social

mbg.au.dk/en/news-and-...

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

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Reposted by William Garland

RNA Society @rnasociety.bsky.social · Feb 4

We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open!
www2.rnasociety.org

This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025.

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Reposted by William Garland

Cell Press @cellpress.bsky.social · Jan 31

Hello BlueSky! Follow us to stay up to date on the inspiring science published in our journals and more.

To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲

go.bsky.app/TdKYuS7

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William Garland @willgarland.bsky.social · Jan 21

Resident colour blind member of the lab here 🙋‍♂️
Please make your figures friendly to us.

Christine Beeton @christinebeeton.bsky.social · Dec 8

Having a color-blind colleague is a good reminder that we need to be more careful when designing figures for scientific publication 🧪
My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...

Color blind friendly palettes for data visualizations with categories

A discussion of color blind friendly palettes for labeling unique catergories in data visualization.

thenode.biologists.com

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Reposted by William Garland

bioRxiv Genomics @biorxiv-genomic.bsky.social · Jan 10

Restrictor slows early transcription elongation to render RNA polymerase II susceptible to termination at non-coding RNA loci https://www.biorxiv.org/content/10.1101/2025.01.08.631787v1

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William Garland @willgarland.bsky.social · Jan 7

Is there a common contaminant database for proximity labelling-MS data? I see that the CRAPome has a section for proximity-dependent biotinylation but it is limited to human cells.
I keep seeing the same nonsense proteins enriched in mTurbo-experiments and would love to know if this is common crap.

Reposted by William Garland

MRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · Dec 29

40 years ago all of Genbank was published in print form by NAR. The same format today would require over 4 light seconds of shelf space. To a year of progress in 2025.

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William Garland @willgarland.bsky.social · Dec 21

Cell lines are frozen, chrome tabs, spreadsheets and documents have been closed. All done for this year ✌️
Back in Derbyshire and busy making sausage rolls.
It's been a productive year, but i'm in dire need of a break.

William Garland @willgarland.bsky.social · Dec 13

This project was speaheaded by Guifen Wu and is now available online at @naturecomms.bsky.social
doi.org/10.1038/s414...

RNA 3′end tailing safeguards cells against products of pervasive transcription termination - Nature Communications

Pervasive transcription generates numerous unadenylated RNAs, usually degraded by the NEXT/nuclear exosome pathway. Here, the authors show that, upon NEXT inactivation, these RNAs are removed by compe...

doi.org

William Garland @willgarland.bsky.social · Dec 13

📢 Latest publication from the lab! We explore how cells manage the excess pA− RNAs generated by pervasive transcription. While the NEXT complex usually takes charge, in its absence, a network of tailing enzymes, export factors, and exonucleases steps in to modify and degrade these RNAs.

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Reposted by William Garland

Gav Armstrong @nchemgav.bsky.social · Dec 10

Don't use red and green data lines/surfaces in the same panel please #chemsky. It can be difficult for some colorblind readers to differentiate them. I've accepted (in principle) 2 papers today, and both sets of authors were asked to remove red/green colour contrasts www.nature.com/articles/d41...

Colour me better: fixing figures for colour blindness

Images can be made more accessible by choosing hues, shapes and textures carefully.

www.nature.com

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