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Michelle Percharde

@mpercharde.bsky.social

700 followers 570 following 52 posts

Transposons, chromatin, development. Group leader @ the MRC LMS in London and UKRI FLF. Mum of 2, she/her. Www.perchardelab.com

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Michelle Percharde @mpercharde.bsky.social · Nov 26

Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)

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Reposted by Michelle Percharde

Transposon and Cancer Epigenetics Group @deniz-lab.bsky.social · 6d

We have a new PhD studentship in the lab on the immunogenic roles of transposable elements in paediatric acute myeloid leukaemia! Come and work with us! www.colcc.ac.uk/2026-cyp-phd...

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Reposted by Michelle Percharde

Science News @scinews.bsky.social · 18d

World’s first AI-designed viruses a step towards AI-generated life. #Nature

Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.

www.nature.com/articles/d41...

World’s first AI-designed viruses a step towards AI-generated life

Scientists used AI to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.

www.nature.com

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Michelle Percharde @mpercharde.bsky.social · 19d

Come be our head of bioinformatics at @mrc-lms.bsky.social !

Our bioinformatics team are closely involved with lots of interesting science and we love working with them. Topics inc. development, cancer, metabolism, aging, TEs (my favourite of course 😜) #TEsky lms.mrc.ac.uk/work/vacanci...

Head of Bioinformatics - MRC Laboratory of Medical Sciences

We are recruiting for a Head of Bioinformatics to lead our Bioinformatics facility

lms.mrc.ac.uk

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Michelle Percharde @mpercharde.bsky.social · Aug 14

Great to see this out in final form. Congrats Abby!

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Reposted by Michelle Percharde

Oded Rechavi @odedrechavi.bsky.social · Jul 31

it appears your low-hanging-fruit phd project wasn't so risk free after all, mr. bond

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Reposted by Michelle Percharde

Helena Cocheme @cochemelab.bsky.social · Jul 27

Join the #LMS! Our institute is advertising for junior #GroupLeader positions in #Physiology and #Metabolism. Closing date for applications: August 31st!

MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · Jul 25

📢 We have PLT openings!

If you carry out ambitious research in an area relevant to Human Metabolic Disease then get in touch! We are especially interested in research focused in Metabolic Physiology using murine and/or human in vivo models and Immunometabolism.

Apply now!

Programme Leader Track - MRC Laboratory of Medical Sciences

We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.

lms.mrc.ac.uk

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Reposted by Michelle Percharde

MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · Jul 9

A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue.

A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.

Study reveals the hidden benefits of weight loss on fat tissue

Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...

lms.mrc.ac.uk

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Michelle Percharde @mpercharde.bsky.social · Jul 8

🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open.

www.symposia.org.uk/courses/stem...

Poster for Genesis Research Trust / BSDB symposium on metabolism and stem cells

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Reposted by Michelle Percharde

Vicki Metzis @vmetzis.bsky.social · Jun 27

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

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Michelle Percharde @mpercharde.bsky.social · Jun 26

The Chromatin And Development lab are hiring a postdoc!

Come join us; we are a happy and hard working team @mrc-lms.bsky.social in London UK. Projects span the intersection of chromatin and transposon biology in dev't and disease. Email/DM for more info. Pls RT!

lms.mrc.ac.uk/work/vacanci...

MRC Postdoctoral Research Scientist - MRC Laboratory of Medical Sciences

The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS...

lms.mrc.ac.uk

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Reposted by Michelle Percharde

🎃 Boo-nas 🦇 Karlscream 👻 Ghåstrøm, 🕷️ PhD ☠️ @pigalopp.no · May 28

This should almost have an international reach: about what the rainbow flag means for queer people, by Oslo Pride.

Gjert Moldestad @gjertm.bsky.social · May 28

For noen kan et lite regnbueflagg bety at vi føler oss tryggere. Man ser flagget og tenker; « her kan jeg passe inn»
En enkel måte å vite at jeg også blir satt pris på.

Veldig fin video
Oslo Pride🌈

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Michelle Percharde @mpercharde.bsky.social · May 26

LTRs as dogs…can be friendly, quite helpful at times. LINEs as cats? Also pretty nice in some cases, but also will get angry and scratch out your eyes. Hmm #TEsky 🤔

Annika Barber @annikabarber.bsky.social · May 26

I love the concept of domesticated transposable elements. I like that my genome has its little viral pets to feed nucleic acids and take out for transcriptional walkies. 🧬

Reposted by Michelle Percharde

Annika Barber @annikabarber.bsky.social · May 26

I love the concept of domesticated transposable elements. I like that my genome has its little viral pets to feed nucleic acids and take out for transcriptional walkies. 🧬

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Michelle Percharde @mpercharde.bsky.social · May 20

I feel like the clusters of pistachios (?) are significant here hmmm

Reposted by Michelle Percharde

Development @dev-journal.bsky.social · May 16

In this Review, @bryonyleeke.bsky.social, Imke Staffhorst and @mpercharde.bsky.social @mrc-lms.bsky.social explore roles of the nucleolus in mammalian development, focusing on genome organisation and chromatin regulation:
doi.org/10.1242/dev....

Figure 1 Nucleolar structure and rRNA gene organisation.

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Michelle Percharde @mpercharde.bsky.social · May 14

Good things come to those who wait! 😅 congratulations @lab-turner.bsky.social on this exciting work and what a day for @bryonyleeke.bsky.social 💪🏼

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Michelle Percharde @mpercharde.bsky.social · May 14

Big thanks to @bryonyleeke.bsky.social and Imke Staffhorst for all their hard work on the planning and content, (and Imke's talented ilustrative work), to helpful reviewers, and to @dev-journal.bsky.social for a smooth and efficient review process.

Michelle Percharde @mpercharde.bsky.social · May 14

The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more.

journals.biologists.com/dev/article/...

nucleoli are dynamically reprogrammed in early mammalian development

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Michelle Percharde @mpercharde.bsky.social · May 13

I love GRCs..they feel friendly and much more accessible previously as a postdoc and even now as a mid-(still early??) career PI than many meetings. And looking forward to the GRC epigenetics one in Aug!

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Michelle Percharde @mpercharde.bsky.social · May 7

Calling undergrads! Our summer internship programme @mrc-lms.bsky.social is still open if you want to try out a summer research project. Great way to get a taste of research, inc a generous stipend. Lots of interesting labs are hosting, including us ;) Closing 15/5/25.
lms.mrc.ac.uk/work-and-stu...

LMS Undergraduate Summer Programme - MRC Laboratory of Medical Sciences

Our LMS Undergraduate Summer Programme is a fantastic, fully-funded opportunity for undergraduate students to gain hands on laboratory experience to support their scientific journeys.

lms.mrc.ac.uk

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Reposted by Michelle Percharde

Transposon and Cancer Epigenetics Group @deniz-lab.bsky.social · May 6

I am excited to share our lab's first review out with in Blood Cancer Journal. We discuss the impact of transposable elements on genome regulation and variation in both normal
haematopoietic processes and haematological cancers. www.nature.com/articles/s41...

Transposable elements as genome regulators in normal and malignant haematopoiesis - Blood Cancer Journal

Blood Cancer Journal - Transposable elements as genome regulators in normal and malignant haematopoiesis

www.nature.com

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Michelle Percharde @mpercharde.bsky.social · Apr 30

Very nice, congratulations! I remember seeing and liking this story at ICTE. Of course you didn’t have to convince me that TEs can play important roles in development… 😍

Reposted by Michelle Percharde

Barbara Pernaute @bpernaute.bsky.social · Apr 23

🚨🚨#Hiring!

3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG

📆 Apply by 23rd May 2023

🔗Details below

@sebioldev.bsky.social

Please RT!🙏

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Reposted by Michelle Percharde

Itai Yanai @itaiyanai.bsky.social · Apr 28

Barbara McClintock proposed – over 40 years ago – that transposable element activity could be a response to stress, and I think that we are still only beginning to understand how right she was.

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Reposted by Michelle Percharde

Marco Trizzino @marcotrizzino.bsky.social · Apr 7

New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n
www.biorxiv.org/content/10.1...

Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration

Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...

www.biorxiv.org

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