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Reposted by Oded Rechavi

Thiago Carvalho @cyrilpedia.bsky.social · 2d

Like so, fm Bracha, @odedrechavi.bsky.social et al

www.nature.com/articles/s41...

Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons - Nature Microbiology

Toxoplasma gondii secretion systems can be engineered to deliver multiple large therapeutic proteins to neurons in vitro and in vivo.

www.nature.com

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Oded Rechavi @odedrechavi.bsky.social · 1d

Fwd: Fwd: “I hope this email finds you well”

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Reposted by Oded Rechavi

Stefan Schoenfelder @stefanschoenfelder.bsky.social · 3d

This paper uncovers that HERVK LTR5Hs, a hominoid-specific retrovirus, act as epiblast enhancers with a crucial function in human pre-implantation development - stunning!
doi.org/10.1038/s415...

A human-specific regulatory mechanism revealed in a pre-implantation model - Nature

Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

doi.org

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Oded Rechavi @odedrechavi.bsky.social · 3d

"You're in charge of the autoclave"

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Oded Rechavi @odedrechavi.bsky.social · 3d

Thanking the reviewers

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Reposted by Oded Rechavi

Parvathy (She/Her) @parvathyv.bsky.social · 4d

I absolutely loved reading this one recently!

The authors show how AMPK (which is traditionally viewed as an stress-activated kinase) is also developmentally regulated by circulating adenosine levels in Drosophila.

www.nature.com/articles/s41...

Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology

Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.

www.nature.com

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Reposted by Oded Rechavi

Jan Blaha @jahabla.bsky.social · 4d

This graced our journal club recently

One-shot design of functional protein binders with BindCraft - Nature

BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.

www.nature.com

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Oded Rechavi @odedrechavi.bsky.social · 4d

If you like chess check out Igor Smirnov's brilliant channel, for example this crazy puzzle (and the historic story around it): youtu.be/IyyRCwKtChM?...

Only Mikhail Tal Could Solve This Crazy Puzzle! [Even Kasparov Failed]

YouTube video by Remote Chess Academy

youtu.be

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Oded Rechavi @odedrechavi.bsky.social · 4d

Yes, it's shut down, hopefully temporarily

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Reposted by Oded Rechavi

Dr Yvonne Couch @dryvonnecouch.bsky.social · 5d

Ok so this is almost certainly not up your street but I LOVE this paper because it is simple, beautifully written and super clear. It's just a good paper and I fangirled the senior author about it in an email to him

www.jneurosci.org/content/40/2...

Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium

Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood and cognition. In vulnerable individuals, acute...

www.jneurosci.org

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Reposted by Oded Rechavi

FocalPlane @focalplane.bsky.social · 5d

Don't forget to check out the recommendations from the preLights team on our sister site @prelights.bsky.social.
prelights.biologists.com

Also, if you are interested in bioimage analysis, our latest preprint list will be dropping soon!

Oded Rechavi @odedrechavi.bsky.social · 5d

Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇

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Reposted by Oded Rechavi

Yehu Moran @yehumoran.bsky.social · 5d

bsky.app/profile/yehu...

Yehu Moran @yehumoran.bsky.social · 5d

My first ever non-peer reviewed science-related piece. Together with Howard Wolinsky and Holger Breithaupt @embopress.org

It's about how scientists critical of de-extinction are targeted by dark PR tactics: www.embopress.org/doi/full/10....

Scientists targeted by dark PR tactics: Several academic scientists critical of de-extinction projects have become the targets of anonymous smear articles and weaponized copyright infringement claims:...

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

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Reposted by Oded Rechavi

christoph_STCmicrobeblog @christophstc.bsky.social · 5d

luckily, there are alternatives to PubMed, see libguides.exeter.ac.uk/c.php?g=7252...

LibGuides: Alternatives to United States NLM Resources: Databases which use PubMed

libguides.exeter.ac.uk

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Reposted by Oded Rechavi

Gerrich @gerrich.bsky.social · 5d

I really love this experimental study on emergence of plasmid stability by @daganlab.bsky.social

They cleverly mimicked fluctuations in antibiotic levels to catch the evolution of stable plasmids that still carry antibiotic resistance.

Very insightful for plasmid evolution!

Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance - Nature Communications

It is expected that plasmids are costly and therefore that selection is required to maintain them within bacterial populations. Here, Wein et al. show that plasmid stability can emerge even in the absence of positive selection and that loss may be determined by transcription-replication conflict.

www.nature.com

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Reposted by Oded Rechavi

Gal Ofir @galofir.bsky.social · 5d

This one by @helenbrabs.bsky.social !

Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping

Nature Plants - Rapid discovery of functional resistance genes is enabled by a high-expression signature and high-throughput transformation. This approach identified 31 new resistance genes for...

www.nature.com

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Oded Rechavi @odedrechavi.bsky.social · 5d

that's amazing

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Reposted by Oded Rechavi

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 5d

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

www.biorxiv.org/content/10.1...

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

www.biorxiv.org

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Oded Rechavi @odedrechavi.bsky.social · 5d

Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇

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Oded Rechavi @odedrechavi.bsky.social · 5d

"Republic has no need for savants and chemists"

(the political court that sentenced Antoine
Lavoisier to the guillotine, 1794)

*from Paul Nurse's new book