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cyrilpedia.bsky.social
Thiago Carvalho
@cyrilpedia.bsky.social
5.1K followers 6K following 10K posts
I've worked on all of science, from T cells to B cells. https://fellowsherpa.com
fellowsherpa.com
Posts Media Videos Starter Packs
Reposted by Thiago Carvalho
clauswilke.com
Claus Wilke @clauswilke.com · 1d
Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...
We still can’t predict much of anything in biology
Biology is hard. Yes, even for AI.
blog.genesmindsmachines.com
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cyrilpedia.bsky.social
Thiago Carvalho @cyrilpedia.bsky.social · 1m
"Risks"?

'(...) an open letter alleging Musk had breached the society’s code of conduct attracted thousands of signatures — but no action resulted. Two fellows have resigned. The Royal Society risks looking like a bystander as reason & rationality come under sustained global assault from populism'
The Royal Society should be protecting science, not Musk
The esteemed club risks becoming a bystander as reason and rationality come under attack
www.ft.com
cyrilpedia.bsky.social
Thiago Carvalho @cyrilpedia.bsky.social · 6m
Ele esta tentando provocar um pogrom em Lisboa.
Reposted by Thiago Carvalho
shyznogd.bsky.social
Shyznogud @shyznogd.bsky.social · 21h
A repugnância q a escolha cirúrgica da referência ao Martim Moniz (é só um "exemplo",sem naaaaaaada a ver com alimentar xenofobia, claro)me causa cresce com a sonsice da resposta dada ao DN ("faz parte da primeira divisão").
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Reposted by Thiago Carvalho
ecotype.bsky.social
Ecotype @ecotype.bsky.social · 31m
Hang in there Portland & Chicago!
bagleycartoons.bsky.social
Pat Bagley @bagleycartoons.bsky.social · 1d
Thugs
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Reposted by Thiago Carvalho
pilhoferlab.bsky.social
Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 9h
🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social[email protected] trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...
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Reposted by Thiago Carvalho
cyrilpedia.bsky.social
Thiago Carvalho @cyrilpedia.bsky.social · 23h
Taking work life balance to the max:
“I have been trying to get a hold of him myself. I think he may be backpacking in the backcountry in Idaho,” Bluestone told AFP.
www.theguardian.com/science/2025...
Nobel committee unable to reach prize winner who is ‘living his best life’ hiking off grid
Fred Ramsdell was among those honoured with a 2025 Nobel Prize in Medicine but might not know because he is somewhere in Idaho and uncontactable
www.theguardian.com
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Reposted by Thiago Carvalho
cyrilpedia.bsky.social
Thiago Carvalho @cyrilpedia.bsky.social · 23h
'In many ways, Meta and OpenAI’s new platforms (AI-generated content is already rife on TikTok and YouTube) are a fitting endpoint for social media’s warped evolution from a place where people swapped updates with friends and family, to one with less and less human-to-human interaction.'
Have we passed peak social media?
As platforms degrade into outrage and slop, users are turning away
www.ft.com
1 3 10
Reposted by Thiago Carvalho
cyrilpedia.bsky.social
Thiago Carvalho @cyrilpedia.bsky.social · 22h
Se o seu dia esta dificil, considere a tarefa deste cidadão: traduzir Guimarães Rosa para o alemão

www.youtube.com/watch?v=ydaT...
A obra-prima brasileira que precisou de 15 anos para ser traduzida
YouTube video by DW Brasil
www.youtube.com
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Reposted by Thiago Carvalho
cyrilpedia.bsky.social
Thiago Carvalho @cyrilpedia.bsky.social · 21h
The real Minnesota Declaration, not the compromised second draft

"This slim volume sets out Herzog’s views on truth in a world where technologically enhanced falsehoods proliferate. These appear to be an elaboration of Herzog’s Minnesota Declaration, the 12 statements he made in 1999"
The Future of Truth by Werner Herzog review – profound, or just a prank?
The director’s provocative seventh book takes in toupees, AI and a pig in a sewer. Should we take him seriously?
www.theguardian.com
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Reposted by Thiago Carvalho
cyrilpedia.bsky.social
Thiago Carvalho @cyrilpedia.bsky.social · 21h
'The mechanisms controlling the inclusion of new B cell clones into spontaneous germinal centers (GCs) remain unclear. Using CRISPR-Cas9, we generated 2 autoreactive B cell receptor knock-in strains, M05 and G55, based on B cell receptors from WT GC B cells in WT:564Igi chimeras'
Dynamic control of autoreactive B cells from spontaneous germinal centers
Abstract. Systemic lupus erythematosus is characterized by activation of many self-reactive B cell clones that produce autoantibodies. This can be modeled
academic.oup.com
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Reposted by Thiago Carvalho
cyrilpedia.bsky.social
Thiago Carvalho @cyrilpedia.bsky.social · 20h
'To date, many heat warning systems across Europe consider human-health impacts only implicitly. Here, we place the explicit focus on human-health impacts. Specifically, we assess the pan-European skill of heat-related mortality forecasts for 2022 and 2023; two exceptionally hot summers.'
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
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Reposted by Thiago Carvalho
cyrilpedia.bsky.social
Thiago Carvalho @cyrilpedia.bsky.social · 19h
Brussels once again choosing corporations over the rights of its citizens
elpais.com
EL PAÍS @elpais.com · 19h
🔴 ÚLTIMA HORA | Bruselas expedienta a España por impedir que las aerolíneas cobren por el equipaje de mano
Bruselas expedienta a España por impedir que las aerolíneas cobren por el equipaje de mano
“Restringe la libertad de las compañías aéreas para fijar precios”, señala la Comisión
elpais.com
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Reposted by Thiago Carvalho
shyznogd.bsky.social
Shyznogud @shyznogd.bsky.social · 9h
A desonestidade de Moedas é impressionante. Acaba de partilhar um clip do programa da Júlia (de onde partiu este trabalho da @fcancio.bsky.social )... editando-o, retirando a referência ao Martim Moniz (onde "as jovens não podiam ir" porq as violações tinham aumentado 60%)
shyznogd.bsky.social
Shyznogud @shyznogd.bsky.social · 21h
A repugnância q a escolha cirúrgica da referência ao Martim Moniz (é só um "exemplo",sem naaaaaaada a ver com alimentar xenofobia, claro)me causa cresce com a sonsice da resposta dada ao DN ("faz parte da primeira divisão").
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Reposted by Thiago Carvalho
atherton.bsky.social
Kelsey Atherton @atherton.bsky.social · 13h
'By applying protections meant for vulnerable groups to shield government actors, Apple has created — within its own ecosystem — a new kind of protected class: state power itself."

migrantinsider.com/p/scoop-appl...
SCOOP: Apple Quietly Made ICE Agents a Protected Class
Internal emails show tech giant used anti-hate-speech rules meant for minorities to block an app documenting immigration enforcement.
migrantinsider.com
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Reposted by Thiago Carvalho
felipedlh.bsky.social
Felipe De La Hoz @felipedlh.bsky.social · 14h
You cannot be fucking serious
SCOOP: Apple Quietly Made ICE Agents a Protected Class
Internal emails show tech giant used anti-hate-speech rules meant for minorities to block an app documenting immigration enforcement.
migrantinsider.com
130 1.2K 2.7K
Reposted by Thiago Carvalho
esqueer.net
Alejandra Caraballo @esqueer.net · 14h
ICE is not only chasing down every random brown person in Chicago, they have a cameraman following them to film this for social media. Cruelty and inhumanity as content.
200 2K 5.1K
Reposted by Thiago Carvalho
gracehunterlisa.bsky.social
Lisa @gracehunterlisa.bsky.social · 16h
Ice is a domestic terrorist operation.
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Reposted by Thiago Carvalho
chariselee.bsky.social
Meidas Charise Lee 💙🌊🌴🥥🫘 @chariselee.bsky.social · 16h
WHAT THE F*CK‼️‼️‼️‼️‼️
Chicago’s Reverend David Black of First Presbyterian has been assaulted multiple times by ICE agents during peaceful protest in the city‼️They shot a some kind of non lethal bullet at his head‼️
#PepperBall
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Reposted by Thiago Carvalho
zeynepbaharoglu.bsky.social
Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 16h
Happy to share our new review in Royal Society Open Biology 🎉
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications
tRNA-modifying enzymes in bacterial stress adaptation | Open Biology
Transfer RNAs (tRNAs) and their modifications are central to bacterial translation and physiology, yet their roles in stress adaptation remain underexplored. While extensively studied in eukaryotes, a...
doi.org
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Reposted by Thiago Carvalho
smcgrath.phd
Scott McGrath @smcgrath.phd · 14h
The rapid deployment of clinical AI lacks a standard method for logging its use, which challenges efforts to track performance and safety. A new protocol, MedLog, is proposed to create a universal, event-level log for every AI interaction.
#MedSy #MedAI #MLSky arxiv.org/abs/2510.04033
A global log for medical AI
Modern computer systems often rely on syslog, a simple, universal protocol that records every critical event across heterogeneous infrastructure. However, healthcare's rapidly growing clinical AI…
arxiv.org
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Reposted by Thiago Carvalho
konigvs.bsky.social
Königvs @konigvs.bsky.social · 21h
Entre Ventura e Moedas tenho sérias dúvidas sobre qual é o mais mentiroso
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Reposted by Thiago Carvalho
asm.org
ASM @asm.org · 15h
In a new opinion piece in @statnews.com ASM member Sarah Stanley, Ph.D., emphasizes that safe gain-of-function research is essential to identifying new treatments for diseases like tuberculosis—yet the NIH has imposed unfounded stops: www.statnews.com/2025/10/06/g...
The NIH ordered me to stop my ‘dangerous’ gain-of-function research. It isn’t dangerous at all
Safe gain-of-function research is necessary to identify new treatments for diseases like for tuberculosis — but the NIH has imposed unfounded stops.
www.statnews.com
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Reposted by Thiago Carvalho
whitehouse.senate.gov
Senator Sheldon Whitehouse @whitehouse.senate.gov · 15h
That’s not a “no.”
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Reposted by Thiago Carvalho
tmarchetti.bsky.social
Tommaso Marchetti @tmarchetti.bsky.social · 15h
The main part of my PhD work is published!

We found that targeted IL-2 therapy, instead of worsening HLH, improves disease by driving CD8 T cells into an exhaustion-like state, an immune brake we can harness to control inflammation, challenging the view that IL-2 only boosts CD8 T cell activity.
Selective IL-2 delivery modulates CD8+ T cells in human HLH and ameliorates disease features in a murine model
Primary hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome. In familial HLH, loss-of-function mutations in genes such as Prf1 disrupt perforin-dependent cytolysis, leading to s...
www.jacionline.org
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