Primary hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome. In familial HLH, loss-of-function mutations in genes such as Prf1 disrupt perforin-dependent cytolysis, leading to s...

Fred Ramsdell was among those honoured with a 2025 Nobel Prize in Medicine but might not know because he is somewhere in Idaho and uncontactable The Nobel committee has been unable to reach a winner of this year’s prize for medicine who is “living his best life” on an “off the grid” hiking foray. Fred Ramsdell shared Monday’s prestigious prize with Mary Brunkow of Seattle, Washington and Shimon Sakaguchi of Osaka University in Japan for their discoveries related to the functioning of the immune system. Continue reading...

Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...

Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...

Haemophagocytic lymphohistiocytosis (HLH), a life-threatening hyperinflammatory disorder often drive

Podcast Episode · Night Science · 11/25/2024 · 51m