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Reposted by Adrian Liston

Hashem Koohy @hkoohy.bsky.social · 9h

Highly motivated and talented candidates are strongly encouraged to apply

Adrian Liston @labliston.bsky.social · 12h

Computational PhDs - this is a really special post-doc opportunity to join @hkoohy.bsky.social's lab at the @imm.ox.ac.uk in Oxford. It is part of a dream collaboration to identify the antigens recognised by Tregs - I'm so excited that we are really doing this!

www.jobs.ac.uk/job/DOX009/s...

Senior Postdoctoral Researcher - Computational Biology at University of Oxford

Discover Senior Postdoctoral Researcher - Computational Biology jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.

www.jobs.ac.uk

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Adrian Liston @labliston.bsky.social · 12h

Computational PhDs - this is a really special post-doc opportunity to join @hkoohy.bsky.social's lab at the @imm.ox.ac.uk in Oxford. It is part of a dream collaboration to identify the antigens recognised by Tregs - I'm so excited that we are really doing this!

www.jobs.ac.uk/job/DOX009/s...

Senior Postdoctoral Researcher - Computational Biology at University of Oxford

Discover Senior Postdoctoral Researcher - Computational Biology jobs and more in higher education on jobs.ac.uk. Apply for further details on the top job board.

www.jobs.ac.uk

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Adrian Liston @labliston.bsky.social · 15h

You’re right! There was actually a ton of great pre-Foxp3 work going on, before Tregs went mainstream

Adrian Liston @labliston.bsky.social · 1d

Enormous loss. Vale John Gurdon.

James Briscoe @jamesbriscoe.bsky.social · 1d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Reposted by Adrian Liston

Tuure Kinnunen @tuurekinnunen.bsky.social · 1d

Yes, Tregs finally getting the spotlight they deserve! 🙌

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Reposted by Adrian Liston

RyanLab_TCD @ryanlab.bsky.social · 1d

Check out a lovely bitesize historical perspective from Adrian below.

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Reposted by Adrian Liston

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Adrian Liston @labliston.bsky.social · 2d

Along with Sasha Rudensky, one of the other giants of the field, who did his key Treg work at UW! Seattle was at the epicentre of the Treg world!

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Adrian Liston @labliston.bsky.social · 2d

Yep! 2003 were the key papers. Things changed really fast!

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Reposted by Adrian Liston

Trends in Genetics @cp-trendsgenetics.bsky.social · 2d

Today's Nobel Prize announcement was a win for the field of genetics as well. Congrats to all involved!

Adrian Liston @labliston.bsky.social · 2d

In 2003, the key breakthrough happened - groups lead by Sakaguchi, Ramsdell and Sasha Rudensky all demonstrated that FOXP3, the IPEX gene, was also the master transcription factor that made Tregs immunosuppressive. Suddenly everyone could study Tregs and manipulate their genetics.

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Reposted by Adrian Liston

Marinos Kallikourdis, PhD @kallikourdis.bsky.social · 2d

I've had Sakaguchi papers on my desk since '99, when I was warned against studying cells (Treg) that may not exist. 26 years on, we've shown you need them to reproduce and we may bring them to Heart clinics. A joyous overdue toast to Sakaguchi's steadfast building of the foundations of our science!

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Reposted by Adrian Liston

ImmuNinjas @immuninjas.bsky.social · 2d

Congratulations! #NobelPrize #Tregi

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Reposted by Adrian Liston

Jarrod Dudakov @dudakov-lab.bsky.social · 2d

Great primer. Also great to see peripheral tolerance recognized, but I will note you can’t get tregs without central tolerance and the thymus! Miller snubbed again!

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Adrian Liston @labliston.bsky.social · 2d

The thymus needs its own Nobel Prize, not a shared one with Tregs!

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Reposted by Adrian Liston

Jesse Garcia Castillo, PhD @jgcastillo.bsky.social · 2d

Great to see Tregs win a Nobel prize!!

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Reposted by Adrian Liston

Maximilian Frosch @mfrosch.bsky.social · 2d

Great recap of the story and the breakthroughs behind the 2025 #NobelPrize in Physiology or Medicine! 🏅🏅🏅

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Reposted by Adrian Liston

Oleg Ko @okolupaev.bsky.social · 2d

This summary is exactly what you need to know about todays Nobel prize winners and their contributions to our understanding of the immune system

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Reposted by Adrian Liston

Denise Fitzgerald @deefitzgerald.bsky.social · 2d

Great summary on the back story to this year's Nobel Prize

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Reposted by Adrian Liston

Nikolay Kukushkin @niko-kukushkin.bsky.social · 2d

To hold something steady on an outstretched hand, you press down on your wrist with your second hand (e.g. cops holding guns in movies). That, in a nutshell, is why we need these T-regulatory cells that work against actual antiviral T-cell fighters. Congratulations!

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Adrian Liston @labliston.bsky.social · 2d

Huge congratulations not only to the team leaders, but all the students, technicians and expert scientists who did the work that underpins this discovery. Their work, and the work of those following in their footsteps, is changing the future for autoimmune, transplant and oncology patients!

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Adrian Liston @labliston.bsky.social · 2d

The impact has been enormous, with Tregs going from being a niche frowned-upon subset of immunology, to underpinning our entire understanding of how the immune system works. Therapies based on boosting Tregs (e.g. IL2) or bypassing Tregs (anti-CTLA4) are in the clinic.

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Adrian Liston @labliston.bsky.social · 2d

In 2003, the key breakthrough happened - groups lead by Sakaguchi, Ramsdell and Sasha Rudensky all demonstrated that FOXP3, the IPEX gene, was also the master transcription factor that made Tregs immunosuppressive. Suddenly everyone could study Tregs and manipulate their genetics.

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Adrian Liston @labliston.bsky.social · 2d

Key experiments on #Tregs were then done by Fiona Powrie and Shimon Sakaguchi. They were chasing different phenotypes and different markers, on what ended up being the same cells - potent immunosuppressive T cells, capable of shutting down immune responses.

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Adrian Liston @labliston.bsky.social · 2d

Completely independent of this, we had the field of regulatory T cells. There were some misleading experiments on "suppressive T cells" early on, but Nicole Le Douarin had used chicken/quail chimeras to prove that some T cells worked to suppress immune responses in the periphery.

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Adrian Liston @labliston.bsky.social · 2d

IPEX was rather mysterious, but because of the inheritance pattern it was quickly mapped to the X chromosome. Several teams of scientists worked on mapping this disorder down to the gene level, with Brunkow and Ramsdell leading the team that identified FOXP3 as the causative gene.

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