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mfrosch.bsky.social
Maximilian Frosch
@mfrosch.bsky.social
23 followers 71 following 3 posts
Neuropathology | Neuroimmunology | @PrinzLab | @University Clinic Freiburg
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mfrosch.bsky.social
Maximilian Frosch @mfrosch.bsky.social · Aug 7
Our brains rely on microglia—they deliver the lysosomal enzyme β-hexosaminidase to neurons to clear toxic GM2 buildup.

And transplanted microglia-like cells can rescue neurodegeneration. Just published in Nature! 🧠

🔗 www.nature.com/articles/s41...
Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis - Nature
Nature - Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis
www.nature.com
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mfrosch.bsky.social
Maximilian Frosch @mfrosch.bsky.social · 2d
Great recap of the story and the breakthroughs behind the 2025 #NobelPrize in Physiology or Medicine! 🏅🏅🏅
labliston.bsky.social
Adrian Liston @labliston.bsky.social · 2d
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
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Reposted by Maximilian Frosch
michael-platten.bsky.social
Michael Platten, MD @michael-platten.bsky.social · 4d
The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...

Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.
The immunology of brain tumors
The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.
www.science.org
10 21
mfrosch.bsky.social
Maximilian Frosch @mfrosch.bsky.social · 10d
🙏🏻
nature.com
Nature @nature.com · 10d
A fresh supply of the immune cells that keep the brain tidy might one day help to treat a host of conditions, from ultra-rare genetic disorders to more familiar scourges, such as Alzheimer’s disease.

go.nature.com/46mGgPA
Swapping old immune cells in the brain with fresh ones could treat disease
Nature - Replacing immune cells called microglia holds promise for addressing brain conditions such as Alzheimer’s disease.
go.nature.com
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Reposted by Maximilian Frosch
science.org
Science Magazine @science.org · 14d
“This is an immensely exciting development for the Huntington’s field.” https://scim.ag/4nnW62z
In a first, a gene therapy seems to slow Huntington disease
Small study suggests uniQure drug could be first successful treatment for devastating brain disorder
scim.ag
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Reposted by Maximilian Frosch
cp-cell.bsky.social
Cell - a Cell Press journal @cp-cell.bsky.social · Aug 21
And a Review on interferons in health and disease www.cell.com/cell/fulltex...
Interferons in health and disease
The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...
www.cell.com
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Reposted by Maximilian Frosch
uni-freiburg.de
Universität Freiburg @uni-freiburg.de · Aug 15
Die #UniversitätFreiburg hat im renommierten #ShanghaiRanking den 5. Platz von 51 deutschen Institutionen erreicht und gehört weiterhin zu den Top 101–150 Universitäten weltweit. ➡️ Mehr dazu: ufr.link/shanghai-2025 #Ranking
Die Gewächshäuser des Botanischen Gartnes der Universität Freiburg spiegeln sich in der Glasfassade des Hilde-Mangold-Hauses. Foto: Klaus Polkowski
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Reposted by Maximilian Frosch
nature.com
Nature @nature.com · Aug 12
Nature research paper: Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1

go.nature.com/4oF4v2G
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 - Nature
Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic neurons and an expanded cognitive capacity in the human brain.
go.nature.com
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mfrosch.bsky.social
Maximilian Frosch @mfrosch.bsky.social · Aug 7
Our brains rely on microglia—they deliver the lysosomal enzyme β-hexosaminidase to neurons to clear toxic GM2 buildup.

And transplanted microglia-like cells can rescue neurodegeneration. Just published in Nature! 🧠

🔗 www.nature.com/articles/s41...
Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis - Nature
Nature - Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis
www.nature.com
1 4
Reposted by Maximilian Frosch
dominicgrun.bsky.social
Dominic Grün @dominicgrun.bsky.social · Jul 21
Join our "Advances in Single-Cell Technologies" meeting in December in Freiburg, co-organised with Marco Prinz and @katrinkierdorf.bsky.social. Excellent line-up of speakers covering spatial technologies, lineage tracing, computational methods, and more.
www.uniklinik-freiburg.de/single-cell-...
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Reposted by Maximilian Frosch
natneuro.nature.com
Nature Neuroscience @natneuro.nature.com · Jul 15
Characterizing plaque-associated #microglia (PAM) and non-plaque-associated microglia (non-PAM) in a mouse model of Alzheimer's disease; non-PAM modulate cell population expansion in response to amyloid deposition and rapidly respond to environmental cues

www.nature.com/articles/s41...
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience
The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...
www.nature.com
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