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Oleg Ko @okolupaev.bsky.social · 2d

This summary is exactly what you need to know about todays Nobel prize winners and their contributions to our understanding of the immune system

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Oleg Ko @okolupaev.bsky.social · Aug 4

I am just catching up on Friday’s Marketplace…@kairyssdal.bsky.social is says that he’s been hosting the program for 20 years! That makes me a listener for the last 17. Started during the 2008 financial crisis, after just making a move to the US for grad school. Thank you Kai for all these years!

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Oleg Ko @okolupaev.bsky.social · Jun 7

Some personal highlights from #CYTO2025:
* new unmixing algorithms for spectral flow from Dave Novo and Ozette
*systematic approach to autofluorescence analysis
* SOULCAP: initiative to standardize the cell type labeling in flow applications

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Oleg Ko @okolupaev.bsky.social · May 31

Full house for the spectral flow cytometry session at #CYTO2025. Great news! This session is going to be recorded and available to view later!

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Oleg Ko @okolupaev.bsky.social · Mar 31

This is true on so many levels! It takes time to pick the right reference controls, it definitely worth a few extra minutes to run them at a slower speed. #flowcytometry

Colibri Cytometry @colibricytometry.bsky.social · Mar 31

Today's tip: when running your single-color controls, take it slow. The tortoise, as it turns out, beats the hare for spectral flow cytometry.
www.colibri-cytometry.com/post/unmixin...

Unmixing: the tortoise beats the hare

Today's tip: when running your single-color controls, take it slow.

www.colibri-cytometry.com

Oleg Ko @okolupaev.bsky.social · Mar 7

Happy “Drive to Survive” Day to those who still celebrate. Just realized that it is the last Buxton season. #f1 #DTS

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Reposted by Oleg Ko

Waggoner Lab @labwaggoner.bsky.social · Feb 21

Review @natimmunol.bsky.social
B cell immunometabolism in health and disease
www.nature.com/articles/s41...

B cell immunometabolism in health and disease - Nature Immunology

In this Review, Matarese and colleagues discuss how immunometabolism controls the physiology and pathophysiology of B cells.

www.nature.com

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Reposted by Oleg Ko

Waggoner Lab @labwaggoner.bsky.social · Feb 19

FGF21 keeps the thymus young @natureaging.bsky.social
Peptide hormone FGF21 acts on thymic epithelial cells to delay age-associated thymic involution and T cell imbalance
www.nature.com/articles/s43...
www.nature.com/articles/s43...
www.nature.com/articles/s43...
@annvgriffith.bsky.social

FGF21 keeps the thymus young - Nature Aging

Age-associated thymic involution causes a reduction in the de novo production of T cells, which results in limited self-protective immunity and an elevated risk of autoimmunity. Two studies have now i...

www.nature.com

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Oleg Ko @okolupaev.bsky.social · Feb 12

Sound a lot like USSR there KGB “watchers” were assigned to every department and plant/factory

Reposted by Oleg Ko

Hannah Isles @hannah-isles.bsky.social · Jan 27

In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.

Human naïve B cells recognize prepandemic influenza virus hemagglutinins

Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.

www.science.org

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Reposted by Oleg Ko

Eric Topol @erictopol.bsky.social · Jan 27

Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

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Reposted by Oleg Ko

bioRxiv Immunology @biorxiv-immuno.bsky.social · Jan 22

Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT https://www.biorxiv.org/content/10.1101/2025.01.16.633453v1

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Reposted by Oleg Ko

Adam Bryant Miller, PhD @abryantmiller.bsky.social · Jan 21

I am hiring for a postdoctoral fellow at UNC Chapel Hill in Child and Adolescent Anxiety and Mood Disorders Program (CHAAMP). The successful candidate will work on my NIH funded program of research on suicide risk among preteens. Please share. Deadline 1/31! unc.peopleadmin.com/postings/290...

Post-Doc Research Associate

The selected candidate will engage in a combination of clinical research activities aligned with a NIMH funded R01 within the Child and Adolescent Anxiety and Mood Disorders Program (CHAAMP). Clinical...

unc.peopleadmin.com

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Oleg Ko @okolupaev.bsky.social · Jan 22

Important resource! There is a tendency to treat children as miniature versions of adults.
🔦spotlight on childhood cancers:
🦠 immune responses to different types of cancer depending on age
🧬 relatively low TMB compared to adult cancers in TCGA
💉 guide the ise this data for precision medicine

Petter Brodin @petterbrodin.bsky.social · Jan 21

New paper alert 📢! (Cell) @cp-cell.bsky.social
- How does immune responses to solid tumors vary by age and tumor characteristics in children?! www.cell.com/cell/fulltex... 🧵1/8

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Oleg Ko @okolupaev.bsky.social · Jan 20

We are one step closer to the HIV vaccine. Great job, DHVI! #HIV #vaccines www.science.org/doi/10.1126/...

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations

An immunogen engineered by computational and structure-based methods activated diverse B cell precursors and induced rare mutations in mouse models.

www.science.org

Reposted by Oleg Ko

Waggoner Lab @labwaggoner.bsky.social · Jan 14

@ImmunityCP preview:
Restimulation by macrophages exhausts T cells
www.cell.com/immunity/ful...
on
www.cell.com/immunity/ful...

Restimulation by macrophages exhausts T cells

Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustio...

www.cell.com

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Reposted by Oleg Ko

Waggoner Lab @labwaggoner.bsky.social · Jan 15

icCITE-seq (intracellular cellular indexing of transcriptomes and epitopes), a scalable method that simultaneously measures surface and intracellular protein levels alongside gene expression across thousands of cells
doi.org/10.1101/2025...

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Oleg Ko @okolupaev.bsky.social · Jan 2

Got Senna’s McLaren MP4/4 Lego set for Christmas. Now I am watching Senna while building Senna’s racing car #F1 #Senna

Oleg Ko @okolupaev.bsky.social · Dec 21

This reminds me of my childhood when we’d have buckets of cabbage undergoing fermentation process all over our small kitchen

Reposted by Oleg Ko

Sarah Ross @sarahhross.bsky.social · Dec 6

New in Science Magazine this week: two research articles and a Perspective describing synthetic biology gene circuitry for bespoke cellular function - in this case applied to T cells!

Research:
buff.ly/41pkAAb
buff.ly/41gMxu0

Perspective
buff.ly/3ZFUUy8

@science.org

Science Magazine @science.org · Dec 5

Two new studies in Science describe synthetic biology-based strategies that expand the possibilities of harnessing immune cells to treat disease.

Learn more in this week's issue: scim.ag/49nfztS

An engineered T cell (center) is designed to deliver therapies to the brain. This T cell displays orange synthetic receptors on its surface, which recognize components of extracellular matrix fibers that are only found in the brain. Within the cell, downstream signaling pathways are programmed to initiate transcription and release a therapeutic payload—shown as light blue protein secretions.

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Reposted by Oleg Ko

Journal of Clinical Investigation @jci.org · Dec 6

Taking the STING out of radiotherapy: STING checkpoints mediate radiation resistance: https://www.jci.org/articles/view/186547

Michael C. Brown et al. comment on a pair of articles by Wen et al. (https://www.jci.org/articles/view/181612) and Zhang et al. (https://www.jci.org/articles/view/181044)

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Reposted by Oleg Ko

Bruce Levine, Ph.D. 🇺🇦 @bllphd.bsky.social · Dec 5

#ASH24 Energy matters! Ketogenic Diet Enhances CAR T Cell Antitumor Function Via β-Hydroxybutyrate #CARTCell #TCell #tcellrx #immunotherapy @PennMedicine
ash.confex.com/ash/2024/web...

a close up of a woman 's face with a surprised look on her face .

ALT: a close up of a woman 's face with a surprised look on her face .

media.tenor.com

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Oleg Ko @okolupaev.bsky.social · Dec 5

A good reminder that I should up my monthly contribution to this fine enterprise.

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Oleg Ko @okolupaev.bsky.social · Dec 4

Even more reasons to migrate to BlueSky

Bluesky @bsky.app · Dec 3

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Altmetric @altmetric.com · Dec 3

There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research.

A Place of Joy.

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Oleg Ko @okolupaev.bsky.social · Dec 3

A good reminder that fluorescent protein (FP) labels can affect the interaction of the tagged protein with other molecules depending on on the nature of FP and its position ( C- vs N- terminus)

Derek Lowe @dereklowe.bsky.social · Dec 2

Fluorescently labeled proteins are essential to research. But we should never forget how messed-up their behavior can be. An example from condensates:

Fluorescent Tags Are Basically Never Silent

www.science.org