Petter Brodin
@petterbrodin.bsky.social
4.8K followers 2.1K following 92 posts
Pediatrician & Professor of Pediatric Immunology Human Systems Immunology MRC LMS, Imperial College London & Karolinska Institutet
Posts Media Videos Starter Packs
Pinned
petterbrodin.bsky.social
Recent paper (Nature)-why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? X/Y or hormones? We study adaptation of immune systems in gender-affirming testosterone treatment: nature.com/articles/s41...
Immune system adaptation during gender-affirming testosterone treatment - Nature
Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...
nature.com
Reposted by Petter Brodin
castltrastondrs.bsky.social
#Medsky🧪 #IDsky #immunosky #publichealth @petterbrodin.bsky.social , @casanovalab.bsky.social et al
To determine the underlying genetic causes & other modifying factors like sex hormones , interferon responses impacting restrained #Tcell responses to #SARSCoV2 & #viralpersistence in #LongCOVID.
petterbrodin.bsky.social
New paper 📣! Pixelgen reports its incredible new Proximity Network Assay (PNA)->3D maps of 155 proteins in single cells by sequencing by barcoded antibodies and in situ rolling circle amplification yields >40,000 spatial nodes/cell: www.biorxiv.org/content/10.1...
petterbrodin.bsky.social
No evidence for neutralizing IL1RN autoantibodies in our cohorts of MIS-C, SARS-CoV2 pneumonia or vaccine-induced myocarditis. onlinelibrary.wiley.com/doi/10.1111/... Great work by Anish Behere in Nils Landegren lab, Uppsala university
Evaluating IL1RA‐Autoantibodies Across SARS‐CoV‐2‐Related Diseases
Click on the article title to read more.
onlinelibrary.wiley.com
petterbrodin.bsky.social
Exciting new cell state model from @arcinstitute.org
arcinstitute.org
Introducing Arc Institute’s first virtual cell model: STATE
petterbrodin.bsky.social
Absolute pleasure to be teaching human systems immunology @efis-immunology.bsky.social summer school in beautiful Alghero, Sardinia.
Reposted by Petter Brodin
longcovidkids.bsky.social
"Children should be included in ongoing and future clinical trials for Long Covid

Age-related protections & regulations must be incorporated, including obtaining institutional review board/research ethics approval along with paediatric assent & parental

publications.ersnet.org/content/erj/...
Header ERS Logo

Editorial | Viewpoint  Open access
Equity in research: a global consensus statement on the urgency of including children in long COVID clinical trials
Lael M. Yonker Binita Kane Etheresia Pretorius David Putrino Sammie McFarland  Petter Brodin Kanecia O. Zimmerman Daniel Munblit  Peter C. Rowe Theo Vos David Warburton Terence Stephenson Danilo Buonsenso  International Meeting on Long COVID in Children Consortium
Reposted by Petter Brodin
rupress.org
New in @jumimmunity.org:

Human #InbornErrorsOfImmunity: 2024 update on the classification from the @iuis-online.bsky.social Expert Committee: rupress.org/jhi/article/...

See also the accompanying diagnostic guide by Bousfiha et al.: rupress.org/jhi/article/...
petterbrodin.bsky.social
Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee url:https://rupress.org/jhi/article/1/1/e20250003/277390/Human-inborn-errors-of-immunity-2024-update-on-the
Reposted by Petter Brodin
milieuinterieur.bsky.social
Amazing study showing protective effect of herpes zoster vaccination against dementia with interesting sex differences @sexdiffimmunity.bsky.social
#vaccines work! #immunosky #medsky
nature.com
Nature @nature.com · Apr 2
Vaccination against shingles might also prevent dementia, such as that caused by Alzheimer’s disease, according to a study of health records from around 300,000 people in Wales.

https://go.nature.com/446nriQ
Does shingles vaccination cut dementia risk? Large study hints at a link
Analysis of nearly 300,000 people finds an association between the shingles jab and a lower rate of dementia — but questions linger.
go.nature.com
Reposted by Petter Brodin
arrdept-ucldom.bsky.social
Co-senior author from this study Prof Coziana Ciurtin will be talking alongside @petterbrodin.bsky.social in a RITA webinar on Sex Biases on Autoimmunity next Tuesday - should be a great discussion. Register 👇 #ImmunoSky #sexdifferences

register.gotowebinar.com/register/822...
Reposted by Petter Brodin
longcovidsupport.bsky.social
🔥1/3. Next in the Fireside Chat series from The #LongCovid Clinic - What You CAN Do!

‘Covid & the Immune System’

🗓️ Wednesday 12th March 2025 at 6pm GMT

@binitakane.bsky.social & @helenoakleigh.bsky.social are joined by Consultant Immunologist @petterbrodin.bsky.social!

Link ⬇️
Image with Dr Binita Kane on the left and Dr Petter Brodin on the right. Text reads COVID AND THE IMMUNE SYSTEM. Dr. Binita Kane talks with Dr. Petter Brodin Garfield Weston Chair and Professor of Paediatric Immunology at Imperial College London
LIVE Wednesday 12th March 2025 18:00 GMT. THE LONG COVID CLINIC - WHAT YOU CAN DO You Tube @LCCWYCD. Also shown is the Long Covid Support logo.
petterbrodin.bsky.social
Thx so much for highlighting!
adlunglab.com
Childhood solid tumors shape immune responses differently by age and type. Systems-level study of 191 pediatric patients reveals key variations, paving the way for precision immunotherapy. Great work by the one-and-only @petterbrodin.bsky.social and teams.

doi.org/10.1016/j.ce... 🧪
Reposted by Petter Brodin
castltrastondrs.bsky.social
#Medsky🧪#oncosky #pedsky @petterbrodin.bsky.social et al . A systems-level analysis of immune responses in 191 children within a population-based cohort with diverse tumors & reveal that age & tumor type shape immune responses differently.#immunotherapies for childhood cancer.
Reposted by Petter Brodin
joshwaterfall.bsky.social
Great #immuno speakers including @belkaidlab.bsky.social @petterbrodin.bsky.social @florentginhoux.bsky.social Arndt Borkhardt, Melanie Conrad, Sonia Garel, Sylvain Latour, Johnny Ludvigsson, Bernard Malissen, Mihai Netea, Anindita Roy and Chenqu Suo
Reposted by Petter Brodin
immunoeditor.bsky.social
To commemorate #RareDiseaseDay, here are some recent #Science #Immunology research papers that elucidate the immune mechanisms underlying certain rare human diseases and/or report new strategies to treat them! @science.org
The February 2024 cover of Science Immunology depicts CRISPR–Cas9–mediated repair of a dysfunctional cytotoxic T cell (red) from an individual with familial hemophagocytic lymphohistiocytosis (FHL), which allows it to secrete normal cytotoxic granules (pink) and effectively kill virally infected B cells (blue). (Credit: A. Fisher/Science Immunology)
Reposted by Petter Brodin
bogunoviclab.bsky.social
It’s approaching. Join us in person. Henry Kunkel Society Meeting on "Genes & Immunity" and join us in Belgrade from April 10-12, 2025. henrykunkelsociety.org/meetings/
#HKS2025 #Immunology 🧬🔬