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Prof John Gordon @profcelentyx.bsky.social · Aug 14

#cancersky #immunosky #antibodysky

Major #CD40 #TherapeuticAntibody Success now breaking
@cp-cancercell.bsky.social

First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer

Fantastic work 👏

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer

Osorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered CD40 agonistic antibody, showing it is safe and induces systemic and durable antitumor immunity in patients with ...

www.cell.com

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Prof John Gordon @profcelentyx.bsky.social · Jul 30

Dr Neil Bodie (June 13, 1955 - July 19, 2025)

It is with a heavy heart that I report the sad news that my "LinkedIn Friend" & Colleague Dr Neil Martin Bodie, passed away on July 19th.

For more about Neil please see: www.linkedin.com/feed/update/...

R.I.P. Dear Friend

Thoughts are with his family

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Prof John Gordon @profcelentyx.bsky.social · Jul 26

Major study, great work 👍

Chrystal Paulos @chrystalpaulos.bsky.social · Jul 25

🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back.
🔗 Read: www.cell.com/cancer-cell/...
🧬This unexpected immune duo sparks tumor immunity.
🖼️Image: See schematic Th17/B cell antitumor action!

Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity

Cole et al. report that adoptively transferred, tumor-specific Th17 cells engage host B cells and drive B cell proliferation and differentiation. These Th17 cells require B cells for sustained immunit...

www.cell.com

Prof John Gordon @profcelentyx.bsky.social · Jul 4

St David’s 🤔 🏴󠁧󠁢󠁷󠁬󠁳󠁿

Prof John Gordon @profcelentyx.bsky.social · Jun 11

#immunosky #cancersky #climatechangesky

#PsychoNeuroImmunology

#ClimateChange / #SocialDivision: A Perfect Storm for Chronic #Inflammation to Seedbed #Cancer?

Intriguing, OPEN ACCESS Opinion Piece now breaking at @wiley.com #Immunology

Inflammation Perfect Storm: Cancer, Climate and Polarisation

Interplay between major global challenges and human health. Climate change and sociopolitical polarisation act as overarching amplifiers, driving specific environmental and psychosocial/policy-relate...

onlinelibrary.wiley.com

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Prof John Gordon @profcelentyx.bsky.social · Jun 7

A Perfect Selection 😉

Gabriel Victora @victora.bsky.social · Jun 5

Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch

www.biorxiv.org/content/10.1...

Replaying germinal center evolution on a quantified affinity landscape

Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...

www.biorxiv.org

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Prof John Gordon @profcelentyx.bsky.social · Jun 7

Fantastic advance 👏

Thiago Carvalho @cyrilpedia.bsky.social · Jun 6

'Here, we report that Fc-optimized anti-CTLA-4 antibodies are potent remodelers of tumor vasculature that increase tumor-associated high endothelial venules (TA-HEVs), specialized blood vessels supporting lymphocyte entry into tumors'
#Immunology #Immunotherapy
www.cell.com/cell-reports...

Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade

Blanchard et al. reveal that Fc-optimized anti-CTLA-4 antibodies remodel tumor vasculature and increase tumor-associated high endothelial venules (TA-HEVs) that support T cell recruitment into tumors....

www.cell.com

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Prof John Gordon @profcelentyx.bsky.social · May 30

Clucking Awesome 🐓

Discovery Immunology @discovimmunol.bsky.social · May 30

How do chickens generate antibody diversity? 🐔🔬

This study maps over 1 million gene conversion events in chicken antibodies, shedding light on how birds diversify their immune response.

🔗 https://bit.ly/45wSe95

#Immunology #VetImmunology #GeneConversion

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Prof John Gordon @profcelentyx.bsky.social · May 30

A fantastic #MS resource from @britsocimm.bsky.social 👍

British Society for Immunology @britsocimm.bsky.social · May 30

🧡 Today is #WorldMSDay - a global moment to raise awareness and stand with everyone affected by multiple sclerosis.

Curious about how the immune system plays a role in MS? Explore our easy-to-digest BiteSized Immunology section on MS.

📖Learn more here: https://bit.ly/4dFYj5i

Prof John Gordon @profcelentyx.bsky.social · May 22

#Immunosky #Cancersky

Antidepressants: A “Dead SERT” for #Immunotherapy!

Open Access @cellpress.bsky.social

@gilliangrafton.bsky.social 😎

Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell ...

www.cell.com

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Prof John Gordon @profcelentyx.bsky.social · May 2

#CancerSky #MedSky

"When #Cancer #Therapy faces STIFF competition"

OPEN ACCESS Review @cp-trendscancer.bsky.social

Tissue mechanics in tumor heterogeneity and aggression

Tumorigenesis ensues within a heterogeneous tissue microenvironment that promotes malignant transformation, metastasis and treatment resistance. A major feature of the tumor microenvironment is the he...

www.cell.com

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Prof John Gordon @profcelentyx.bsky.social · May 1

#ImmunoSky #MedSky #CancerSky

"Strengthening the #GLUT5" for #ACT vs Solid #Tumours"

Breaking OPEN ACCESS Study @britsocimm.bsky.social journal @imtadvances.bsky.social 👏

GLUT5 armouring enhances adoptive T cell therapy anti-tumour activity under glucose-limiting conditions

AbstractBackground. Cancer immunotherapy with engineered T cells has become a standard treatment for certain haematological cancers. However, clinical tria

academic.oup.com

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Prof John Gordon @profcelentyx.bsky.social · Apr 14

#ImmunoSky #InflammationSky #DietSky

#ILC3s #Immunity #Inflammation #Mucosa #Metabolism #Nutrition #Diet #IL22

"Trust Your #Gut" & Stay Off those Big Macs 🍔

@wehi-research.bsky.social researchers Cyril Seillet & Friends "Chew the #Fat" in Breaking OPEN ACCESS Study @cp-immunity.bsky.social

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis

Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...

www.cell.com

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Prof John Gordon @profcelentyx.bsky.social · Apr 13

#ImmunoSky #MedSky #CancerSky #PharmaSky #DrugSky

**BREAKING: Massive layoffs hit the rodent workforce!**

In a historic shift, the FDA is exploring a future without animal studies for drug approvals.

BRILLIANT Joseph Arboleda Velasquez @harvard.edu 🤩👍👏

www.linkedin.com/posts/joseph...

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Prof John Gordon @profcelentyx.bsky.social · Apr 11

#CancerSky #ImmunoSky #MedSky

#Cancer #Aging #Metabolism

#TIME to Watch you Eat'

#Age- & #Diet- instructed Metabolic Rewiring of the #TumorImmuneMicroEnvironment

#TIME-ly review from @unil.bsky.social authors now breaking at @jem.org

rupress.org/jem/article/...

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Prof John Gordon @profcelentyx.bsky.social · Apr 10

…though #Bcells #Antibodies ARE important 😉

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Prof John Gordon @profcelentyx.bsky.social · Apr 10

#ImmunoSky #MedSky

#drugrepurposing

#Inflammation: "Time to halt the #Dopamine rush"

An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis

Now @science.org signaling

The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis

Macrophages perform repeated rounds of phagocytosis in response to an FDA-approved dopamine blocker.

www.science.org

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Prof John Gordon @profcelentyx.bsky.social · Apr 9

😊

Prof John Gordon @profcelentyx.bsky.social · Apr 9

#ImmunoSky
#MedSky
#EarlyCareerResearchers
#Careers
@ki.se

From Serendipity to Success - Researcher blogs % | John Gordon

#Serendipity | Delighted to share this lovely post from the hugely talented Austeja Baleviciute of the Karolinska Institutet 😊 Hopefully will offer some useful tips to early career researchers as they...

www.linkedin.com

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Prof John Gordon @profcelentyx.bsky.social · Apr 9

#ImmunoSky

#Immunotherapy
#ImmuneRelatedAdverseEvents
#Biomarkers

#ICOS+ CD4 #Tcells define #Susceptibility to anti-PD1-induced #Lung #Pathology in the #Aged

#Bcells #Antibodies #TertiaryLymphoidStructures

Breaking Open Access Study @jci-insight.bsky.social

insight.jci.org/articles/vie...

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Prof John Gordon @profcelentyx.bsky.social · Apr 4

Maximizing activity & selectivity of #TherapeuticAntibodies mediated effector functions using Antibody mixtures

Breaking Open Access Study* @tandfresearch.bsky.social #mAbs

*https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2480666?src=exp-la#abstract

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Prof John Gordon @profcelentyx.bsky.social · Apr 3

#Bcells & #VaccinesSaveLives

Towards a pan- #Flu #Vaccine

Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody

Breaking Open Access Study* @jem.org

*https://rupress.org/jem/article/222/6/e20241930/277361/Identification-of-a-seasonal-influenza-vaccine