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Gabriel Victora @victora.bsky.social · 2d

I’ll take it. But I’ll be renewing my bet again next year

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Gabriel Victora @victora.bsky.social · 3d

Very

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Gabriel Victora @victora.bsky.social · 4d

I would be happy to be wrong in that case!

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Gabriel Victora @victora.bsky.social · 4d

Renewing my yearly bet on Cooper/Miller for the Nobels.

One might think that I would learn after being wrong so many times, but one would be mistaken.

laskerfoundation.org/winners/b-an...

B and T cells—the organizing principle of the adaptive immune system - Lasker Foundation

For their discovery of the two distinct classes of lymphocytes, B and T cells – a monumental achievement that provided the organizing principle of the adaptive immune system and launched the course of...

laskerfoundation.org

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Gabriel Victora @victora.bsky.social · 10d

@cyrilpedia.bsky.social is biased, I’ve grilled him too many steaks

Thiago Carvalho @cyrilpedia.bsky.social · 11d

If you want to deep dive in to immunology you could do worse than Gabriel's evolutionary landscaping

www.biorxiv.org/content/10.1...

Replaying germinal center evolution on a quantified affinity landscape

Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...

www.biorxiv.org

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Reposted by Gabriel Victora

The Rockefeller University @handle.invalid · 22d

Congratulations to all, especially Rockefeller's @veenapadmanaban.bsky.social, a research associate in
@sohailtavazoie.bsky.social's lab, and Maria Cecilia Campos Canesso, formerly a postdoc in @danmucida.bsky.social and @victora.bsky.social’s labs. A very well-deserved recognition!

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Gabriel Victora @victora.bsky.social · Aug 27

Congrats!! Increadibly well deserved, at the risk of stating the obvious!

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Reposted by Gabriel Victora

Hypothesis Fund @hypothesisfund.bsky.social · Aug 19

2/ Did adaptive immune cells learn to cooperate before the modern immune system existed? Awardee @affinityborn.bsky.social may redefine what's essential for immune memory & enable alternative immune architectures.
🥳 Congrats Dr. Wesemann! @harvardmed.bsky.social
🙏 #HFScout @victora.bsky.social

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Reposted by Gabriel Victora

psathyrella.bsky.social @psathyrella.bsky.social · Aug 16

In a new preprint we use deep learning on lineage trees to infer the functional form of the relationship between affinity and fitness that controls antibody evolution in germinal centers: arxiv.org/abs/2508.09871 🧵

Inference of germinal center evolutionary dynamics via simulation-based deep learning

B cells and the antibodies they produce are vital to health and survival, motivating research on the details of the mutational and evolutionary processes in the germinal centers (GC) from which mature...

arxiv.org

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Reposted by Gabriel Victora

Alejandro Montenegro @aemonten.bsky.social · Jun 26

In the minority here, but I think it would be refreshing and I'd appreciate reading a piece like "On the value of reductionist science".

While *incredibly* valuable, not everything *needs* -omics and the like, let alone when only done because it _can_ be done, with an illusion of mechanism.

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Reposted by Gabriel Victora

Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · Jul 4

Oslo University's Johanne Tracey Jacobsen visited CCII this week & shared exciting progress in the application of cutting edge imaging techniques to decode dynamic T-B interactions in the Germinal Center.
#Immunology #GerminalCenter
www.jjacobsenlab.com

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Reposted by Gabriel Victora

Oded Rechavi @odedrechavi.bsky.social · Jul 2

Check it out, a great opportunity for people looking to start their own lab in Japan 👇
www.ccii.med.kyoto-u.ac.jp/en/careers-e...

Open Positions｜Careers｜Center for Cancer Immunotherapy and Immunobiology

Open Positions

www.ccii.med.kyoto-u.ac.jp

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Gabriel Victora @victora.bsky.social · Jul 2

a classic!

Reposted by Gabriel Victora

Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · Jul 2

Germinal center clonal diversity trees as a musical score, a great image to start @victora.bsky.social's CCII seminar, "Replaying germinal center evolution on a quantified affinity landscape"
#GerminalCenter #Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/the...

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Reposted by Gabriel Victora

Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · Jul 1

Following Daniel @danmucida.bsky.social's session, Angelina Bilate @rockefelleruniv.bsky.social discussed strategies to identify antigen specific T cells.

www.science.org/doi/10.1126/...

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Gabriel Victora @victora.bsky.social · Jul 1

@cyrilpedia.bsky.social

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Gabriel Victora @victora.bsky.social · Jul 1

With a little help from my friend

Thiago Carvalho next to a painting of a mouse putting on lipstick

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Reposted by Gabriel Victora

Thiago Carvalho @cyrilpedia.bsky.social · Jul 1

A great start to a 3-day workshop: Daniel & Angelina Bilate discussing with students & postdocs at @ccii-kyoto.bsky.social all the obstacles faced & strategies to overcome them (or, more drastically, the thorny topic of when to pull the plug on a project).
www.ccii.med.kyoto-u.ac.jp/en/event/wor...

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Reposted by Gabriel Victora

Center for Cancer Immunotherapy and Immunobiology @ccii-kyoto.bsky.social · Jul 1

Our streamlined Junior PI application process asks you to submit:
a cover letter;
a research plan;
a current curriculum vitae;
brief narrative summary of your main research achievements;
Contact information for three references
#Immunology #Immunotherapy

www.ccii.med.kyoto-u.ac.jp/en/careers-e...

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Gabriel Victora @victora.bsky.social · Jun 27

Great to be back for the last iteration of this great symposium. It will be missed!

Seth Thomas Scanlon @immunoeditor.bsky.social · Jun 27

I am so delighted to be in #Japan for this year's RIKEN IMS–JSI International Symposium on #Immunology! 🇯🇵

温かく迎えてくれた主催者に感謝する！

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Gabriel Victora @victora.bsky.social · Jun 8

Nice, thank you. Maybe some of these features will turn out to be broadly true whenever there is clonal expansion in adaptive immune systems

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Reposted by Gabriel Victora

William DeWitt @wsdewitt.github.io · Jun 7

I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.

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Gabriel Victora @victora.bsky.social · Jun 7

Thanks for the kind words. I’m curious, what parallels do you mean?

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Reposted by Gabriel Victora

Jeroen Guikema @jeroenguikema.bsky.social · Jun 7

Another tour de force by the Victora lab. A must read for germinal center aficionados. There goes the weekend!

Gabriel Victora @victora.bsky.social · Jun 5

Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch

www.biorxiv.org/content/10.1...

Replaying germinal center evolution on a quantified affinity landscape

Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...

www.biorxiv.org

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Gabriel Victora @victora.bsky.social · Jun 5

Additional credit to multiple members of the Matsen, Victora, and other labs, especially Jared Galloway for coding; @tylernstarr.bsky.social and @jbloomlab.bsky.social for deep mutational scanning; Ward lab for cryo-EM; and @thearmita.bsky.social and @yun-s-song.bsky.social for help with modeling

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