Center for Cancer Immunotherapy and Immunobiology
@ccii-kyoto.bsky.social
800 followers 720 following 68 posts
Conquering cancer by advancing immunotherapy. The CCII is a research center at Kyoto University, led by Nobel Laureate Prof Tasuku Honjo. https://www.ccii.med.kyoto-u.ac.jp/en/
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Reposted by Center for Cancer Immunotherapy and Immunobiology
ccii-kyoto.bsky.social
A promising new avenue for non-opiod pain management fm CCII's Hagiwara group, using dexmedetomidine (a α2-adrenergic receptor agonist) without cardiovascular side effects in mice & NHPs. An oral tablet formulation of the candidate drug is currently in phase I/II trials.
www.pnas.org/doi/abs/10.1...
Discovery and development of an oral analgesic targeting the α2B adrenoceptor | PNAS
Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation through an α2A-adrenergic receptor. Hence, α2-adrenergic agonis...
www.pnas.org
Reposted by Center for Cancer Immunotherapy and Immunobiology
ccii-kyoto.bsky.social
The conference was held in Basel & Sidonia also took the opportunity to pay homage to Fritz Melchers, former Director of the Basel Institute of Immunology.

The BII has closed, but you can read about it in this 1997 @currentbiology.bsky.social piece 👇

www.cell.com/current-biol...
Reposted by Center for Cancer Immunotherapy and Immunobiology
ccii-kyoto.bsky.social
CCII's Sidonia Fagarasan presenting on "The intersection of adaptive & innate immunity in the lung: implications for chronic pulmonary insufficiency" at the @embo.org workshop on Adaptive Immunity at Barrier Tissues organized by @immunologyking.bsky.social @maurogaya.bsky.social
#EMBObarrierTissues
Reposted by Center for Cancer Immunotherapy and Immunobiology
ccii-kyoto.bsky.social
To find out more about research in the Hagiwara group at CCII, click on 👇
www.ccii.med.kyoto-u.ac.jp/en/research/...
ccii-kyoto.bsky.social
The conference was held in Basel & Sidonia also took the opportunity to pay homage to Fritz Melchers, former Director of the Basel Institute of Immunology.

The BII has closed, but you can read about it in this 1997 @currentbiology.bsky.social piece 👇

www.cell.com/current-biol...
ccii-kyoto.bsky.social
CCII's Sidonia Fagarasan presenting on "The intersection of adaptive & innate immunity in the lung: implications for chronic pulmonary insufficiency" at the @embo.org workshop on Adaptive Immunity at Barrier Tissues organized by @immunologyking.bsky.social @maurogaya.bsky.social
#EMBObarrierTissues
ccii-kyoto.bsky.social
To find out more about research in the Hagiwara group at CCII, click on 👇
www.ccii.med.kyoto-u.ac.jp/en/research/...
ccii-kyoto.bsky.social
A promising new avenue for non-opiod pain management fm CCII's Hagiwara group, using dexmedetomidine (a α2-adrenergic receptor agonist) without cardiovascular side effects in mice & NHPs. An oral tablet formulation of the candidate drug is currently in phase I/II trials.
www.pnas.org/doi/abs/10.1...
Discovery and development of an oral analgesic targeting the α2B adrenoceptor | PNAS
Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation through an α2A-adrenergic receptor. Hence, α2-adrenergic agonis...
www.pnas.org
ccii-kyoto.bsky.social
To find out more about research in the Hagiwara group at CCII, click on 👇

www.ccii.med.kyoto-u.ac.jp/en/research/...
Reposted by Center for Cancer Immunotherapy and Immunobiology
leonidasplatan1.bsky.social
“I have a friend who told me: “This is my last round in my life because I have lung cancer”. But half a year later he came back and had just started the treatment we developed, and he was just completely cured.”

Tasuku Honjo (1942- )
NobelPrize in Medicine 2018
Reposted by Center for Cancer Immunotherapy and Immunobiology
natrevimmunol.nature.com
Happy 50th birthday to monoclonal antibodies! While researching antibody diversity, Köhler and Milstein developed a technique for generating large amounts of monoclonal antibodies: www.nature.com/articles/256... #immunosky #immunology
Continuous cultures of fused cells secreting antibody of predefined specificity - Nature
Nature - Continuous cultures of fused cells secreting antibody of predefined specificity
www.nature.com
Reposted by Center for Cancer Immunotherapy and Immunobiology
aai.org
🗓️ Mark your calendars – #IMMUNOLOGY2026™ abstract submissions open on September 3! Get ready to share your latest research with the global immunology community. ow.ly/ekqM50WBK9q

#immunology #scicomm
Reposted by Center for Cancer Immunotherapy and Immunobiology
cyrilpedia.bsky.social
A great talk — Hiroshi has just arrived back in Japan after a postdoc in Ron Germain's lab & he showed some beautiful 3D high rez images. The paper is not out yet, but watch this space
ccii-kyoto.bsky.social
Sidonia Fagarasan introducing CCII seminar speaker Hiroshi Ichise (University of Osaka). He presented advances in 3D imaging & what new biology it can help reveal, including a new immune cluster organized around the vagal nerves in the lung
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
Reposted by Center for Cancer Immunotherapy and Immunobiology
whysharksmatter.bsky.social
Hey everybody! @drjuliawester.bsky.social and I have a new paper!

We surveyed over 800 scientists, science communicators, and science educators who use social media.

Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑

doi.org/10.1093/icb/...
Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky
Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For
doi.org
ccii-kyoto.bsky.social
Sidonia Fagarasan introducing CCII seminar speaker Hiroshi Ichise (University of Osaka). He presented advances in 3D imaging & what new biology it can help reveal, including a new immune cluster organized around the vagal nerves in the lung
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
ccii-kyoto.bsky.social
Tomorrow (Tuesday) at CCII, Hiroshi Ichise on
“Highly multiplex volumetric imaging Ce3D-IBEX reveals commensal-induced immune clustering along sensory nerves in the lung”
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Reposted by Center for Cancer Immunotherapy and Immunobiology
iaslc.bsky.social
#NACLC25 is open! Registration & abstracts are live for Dec 5–7, 2025, in Chicago.

Hear from co‑chairs @kamarronemd.bsky.social & Ramesh Rengan, MD, PhD, FASTRO on Lung Cancer Considered—insights, highlights & why you should be there.

🎧 bit.ly/NACLC25Preview

#LungCancer @ascocancer.bsky.social
Preview: IASLC | ASCO 2025 North American Conference on Lung Cancer | IASLC
Join Dr. Stephen Liu on Lung Cancer Considered as he sits down with two co-chairs of the upcoming IASLC | ASCO 2025 North American Conference on Lung Cancer (NA ...
bit.ly
Reposted by Center for Cancer Immunotherapy and Immunobiology
natrevdrugdiscov.nature.com
For readers interested in anticancer drugs, this Review in the July issue discusses progress and challenges in the development of tumour-agnostic kinase inhibitors
www.nature.com/articles/s41...
rdcu.be/eybm4
Kinase gene alterations in cancer
Reposted by Center for Cancer Immunotherapy and Immunobiology
ccii-kyoto.bsky.social
Vice director Sidonia Fagarasan introducing Jianguo (Jeff) Xia from McGill University, who gave a seminar on "Leveraging #metabolomics and biological networks for functional insights into microbiome” this week at CCII.
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
Reposted by Center for Cancer Immunotherapy and Immunobiology
ccii-kyoto.bsky.social
ICYMI
ccii-kyoto.bsky.social
"Here, we investigated the effect of chronological aging on anti–PD-(L)1 therapy–induced irAE-like lung toxicity, utilizing tumor-bearing aged mice"
Yokoi et al show that ICOS upregulation in CD4 T cells is linked to increased adverse ICB effects in the aged lung.
#Immunology #Immunotherapy
ccii-kyoto.bsky.social
ICYMI
ccii-kyoto.bsky.social
"Here, we investigated the effect of chronological aging on anti–PD-(L)1 therapy–induced irAE-like lung toxicity, utilizing tumor-bearing aged mice"
Yokoi et al show that ICOS upregulation in CD4 T cells is linked to increased adverse ICB effects in the aged lung.
#Immunology #Immunotherapy
Reposted by Center for Cancer Immunotherapy and Immunobiology
jjacobsenlab.bsky.social
An unforgettable week of science and collaboration in Kyoto! 🔬 A huge thank you to the brilliant Sidonia Făgărășan and her entire lab for hosting me at the Center for Cancer Immunotherapy and Immunobiology (CCII).

Looking forward to future collaborations!