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natrevimmunol.nature.com
Nature Reviews Immunology
@natrevimmunol.nature.com
7.3K followers 760 following 67 posts
Bluesky account for the journal Nature Reviews Immunology https://www.nature.com/nri/ Skyquakes from the editors.
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Nature Reviews Immunology @natrevimmunol.nature.com · 2d
Happy #treg day everyone - congratulations to Mary Brunkow, Fred Ramsdell, Shimon Sakaguchi and to all the immunologists who have contributed to this incredible field. See our collection: www.nature.com/collections/...
Nobel Prize in Physiology or Medicine 2025
The 2025 Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries ...
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Reposted by Nature Reviews Immunology
thepenkpanther.bsky.social
Alejandra Mendoza @thepenkpanther.bsky.social · 2d
Happy to have our work highlighted on a day when we are celebrating #treg cells! These cells do it all, even modulate how we sense the environment!
natrevimmunol.nature.com
Nature Reviews Immunology @natrevimmunol.nature.com · 2d
Highlight of Science Immunology paper by @thepenkpanther.bsky.social, Alexander Rudensky and colleagues @mskcancercenter.bsky.social @scripps.edu @wcm-imp.bsky.social
#immunology #immunosky #neurosky
Skin Treg cells set the tone for neuronal activation - Nature Reviews Immunology
A study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their production of the opioid enkephalin.
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Nature Reviews Immunology @natrevimmunol.nature.com · 2d
Highlight of Science Immunology paper by @thepenkpanther.bsky.social, Alexander Rudensky and colleagues @mskcancercenter.bsky.social @scripps.edu @wcm-imp.bsky.social
#immunology #immunosky #neurosky
Skin Treg cells set the tone for neuronal activation - Nature Reviews Immunology
A study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their production of the opioid enkephalin.
www.nature.com
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natrevimmunol.nature.com
Nature Reviews Immunology @natrevimmunol.nature.com · 16d
NEW Review of neoadjuvant #immunotherapy in melanoma by Francesca Fallarino & Christian Blank @nkinl.bsky.social discusses where the field is heading next in terms of understanding immune education in therapy resistance and biomarker-driven personalization
#immunology #oncology #cancer #melanoma
Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape - Nature Reviews Immunology
Neoadjuvant (chemo)immunotherapy has become a new standard-of-care option for patients with cancer. This Perspective discusses the lessons learnt for neoadjuvant immunotherapy in the context of melano...
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Reposted by Nature Reviews Immunology
tom-riffel.bsky.social
Tom Riffelmacher @tom-riffel.bsky.social · Sep 8
Just in time for #Cd1Mr12025

Our Review on Innate-like T cell Metabolism is out!

Access free here: rdcu.be/eEV67

Please share with your Immunometabolism friends!

@cd1mr1.bsky.social
@lji.org @uniklinikkoeln.bsky.social
@natureportfolio.nature.com @natrevimmunol.nature.com
Metabolic control of innate-like T cells - Nature Reviews Immunology
Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. This Review describes how metabolic pathway...
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Nature Reviews Immunology @natrevimmunol.nature.com · Sep 5
NEW Review online now
#immunosky
Targeting MHC-E as a new strategy for vaccines and immunotherapeutics - Nature Reviews Immunology
The dual nature of non-polymorphic MHC-E as a ligand for innate receptors and as an antigen-presenting protein raises the possibility of new, universally effective vaccines and immunotherapies for inf...
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Nature Reviews Immunology @natrevimmunol.nature.com · Sep 1
NEW Highlight of @natimmunol.nature.com paper
www.nature.com/articles/s41...
Clock genes keep intestinal ILC3s ticking - Nature Reviews Immunology
A study by Bhattarai et al. in Nature Immunology reports that ILC3-to-ILC1 plasticity in the gut is regulated by circadian clock proteins.
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Reposted by Nature Reviews Immunology
abhishekgarglab.bsky.social
Abhishek Garg LAB @abhishekgarglab.bsky.social · Aug 31
📌In #September @natrevimmunol.nature.com issue, read our #comprehensive #Review: "The #Diversity of #CD8+ T #cell #dysfunction in #cancer and #viral #infection"

⏩Read: www.nature.com/articles/s41...

🤝Result of fruitful #Collaboration w/ @deadoc80.bsky.social @labliston.bsky.social & Kellie Smith!
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who.int
WHO @who.int · Aug 28
#ThrowbackThursday: In 1980 the 🌍🌎🌏 was declared #smallpox free, thanks to mass vaccination efforts.

Smallpox was an acute contagious disease caused by the variola virus. It was one of the most devastating diseases known to humanity. #VaccinesWork
World Health: The Magazine of the World Health Organization. May 1980. smallpox is dead!
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Nature Reviews Drug Discovery @natrevdrugdiscov.nature.com · Aug 21
The aryl hydrocarbon receptor has become a promising target for therapeutic immune modulation in inflammatory diseases, cancer and infections. Read about the field in this review in the August issue
www.nature.com/articles/s41...
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The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation - Nature Reviews Drug Discovery
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of environmental pollutants and regulates innate and adaptive immune responses. This Review discusses how, in the past, AHR activation wa...
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Reposted by Nature Reviews Immunology
adlunglab.com
Lorenz Adlung Lab @adlunglab.com · Aug 20
I must admit, I never quite knew how to imagine functional immune–brain crosstalk in situ. Thanks to our good friends at @aleksdelab.bsky.social, I can now read and see in @natrevimmunol.nature.com!

doi.org/10.1038/s415... 🧪

Immune control of brain physiology
Nature Reviews Immunology - The peripheral immune system communicates with the brain through diverse anatomical routes to shape brain physiology. Here we discuss why such diversity is needed and...
doi.org
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Reposted by Nature Reviews Immunology
aleksdelab.bsky.social
Brain-Immune Communication Lab @aleksdelab.bsky.social · Aug 13
It's great to see our review printed in @natrevimmunol.nature.com and learn that we made the cover!
BRAIN on the cover of an IMMUNOLOGY journal 😍
review here: www.nature.com/articles/s41...
Congratulations again! @marikovacs.bsky.social @amaia-db.bsky.social @fakesamir.bsky.social
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natrevimmunol.nature.com
Nature Reviews Immunology @natrevimmunol.nature.com · Aug 7
And read our special Review from Chan, Martyn & Carter to mark 50 years of monoclonal antibodies: www.nature.com/articles/s41...
Fifty years of monoclonals: the past, present and future of antibody therapeutics - Nature Reviews Immunology
Fifty years ago, Köhler and Milstein introduced the world to hybridoma technology for the generation of monoclonal antibodies. Scientists have subsequently built upon this seminal discovery to develop...
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Nature Reviews Immunology @natrevimmunol.nature.com · Aug 7
This discovery by Köhler and Milstein was revolutionary for biomedical research and drug development. Read the @nature.com editorial on the impact of monoclonal antibodies: www.nature.com/articles/d41...
Monoclonal antibodies revolutionized biomedical science and health care
The story of the discovery of these molecules 50 years ago shows how the free exchange of ideas can lead to life-changing treatments.
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Nature Reviews Immunology @natrevimmunol.nature.com · Aug 7
Happy 50th birthday to monoclonal antibodies! While researching antibody diversity, Köhler and Milstein developed a technique for generating large amounts of monoclonal antibodies: www.nature.com/articles/256... #immunosky #immunology
Continuous cultures of fused cells secreting antibody of predefined specificity - Nature
Nature - Continuous cultures of fused cells secreting antibody of predefined specificity
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Nature Reviews Immunology @natrevimmunol.nature.com · Jul 29
NEW Review from @soreklab.bsky.social @dinahoch.bsky.social explains how immune pathways manipulate the availability of nucleotides, chemically modify nucleotides to generate immune signalling molecules, and produce altered nucleotides that poison viral replication
#immunosky #microsky #phagesky
Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology
Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...
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Reposted by Nature Reviews Immunology
wenjiang-nano.bsky.social
Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Jul 23
Congrats to Adam Grippin, a resident in the radiation oncology program @mdanderson.bsky.social , and soon to be physician scientist, on his latest commentary in @natrevimmunol.nature.com, highlighting a new cell surface mapping technique with implication in understanding immune cell functions.
Mitochondrial proteins go public and novel interactions: insights from surfaceome mapping - Nature Reviews Immunology
A recent preprint by Floyd et al. presents the most comprehensive mapping to date of the human lymphocyte ‘surfaceome’.
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Reposted by Nature Reviews Immunology
filswirski.bsky.social
Fil Swirski @filswirski.bsky.social · Jul 10
Very happy to share this Perspective in @natrevimmunol.nature.com

www.nature.com/articles/s41...
Connection and communication between the nervous and immune systems - Nature Reviews Immunology
Here, Swirski and colleagues explore how the nervous and immune systems connect and collaborate to respond to internal and external stimuli. In particular, they consider how the exchange of informatio...
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Nature Reviews Immunology @natrevimmunol.nature.com · Jul 3
Original preprint here
www.biorxiv.org/content/10.1...
Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia
Bone marrow is both a primary site for blood cell production and a fertile niche for metastatic cancer cell growth, notably in breast cancer. Although anemia is common among patients with bone metasta...
www.biorxiv.org
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Nature Reviews Immunology @natrevimmunol.nature.com · Jul 3
Further discussion from @preprintclub.bsky.social here
www.preprintclub.com/preprint-rev...
2025-may-chaib
www.preprintclub.com
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natrevimmunol.nature.com
Nature Reviews Immunology @natrevimmunol.nature.com · Jul 3
Another Journal Club article from @preprintclub.bsky.social -
Mehdi Chaib and James Allison @mdanderson.bsky.social report on @biorxiv-immuno.bsky.social preprint by Han et al. that describes a mechanism by which metastatic tumours secure iron in the bone marrow
#immunosky #cancersky
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Tumour cells mimic erythroblasts to hijack iron from bone marrow macrophages
Nature Reviews Immunology - A preprint by Han et al. reports that tumour cells acquire iron in the bone marrow through phenotypic mimicry of erythroblasts, which promotes metastasis and leads to...
rdcu.be
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natrevimmunol.nature.com
Nature Reviews Immunology @natrevimmunol.nature.com · Jun 30
More discussion from @preprintclub.bsky.social here:
www.preprintclub.com/preprint-rev...
2025-may-Srivastava
www.preprintclub.com
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Nature Reviews Immunology @natrevimmunol.nature.com · Jun 30
Original preprint here: www.biorxiv.org/content/10.1...
A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes
The evolving antigenic landscape of autoimmune diabetes reflects a dynamic failure to preserve self-tolerance. Yet, how novel neoantigens emerge in humans remains incompletely understood. Here, we des...
www.biorxiv.org
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Nature Reviews Immunology @natrevimmunol.nature.com · Jun 30
NEW Journal Club article from @boyantsankovsci.bsky.social & Dana Philpott @preprintclub.bsky.social highlights a @biorxiv-immuno.bsky.social paper by Srivastava et al. that identifies a previously unknown C19S-modified insulin neoantigen.
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Insulin neoantigen elicits memory T cell activation in diabetes
Nature Reviews Immunology - A preprint by Srivastava et al. reports that C19S modification of insulin, which occurs in response to a stressed microenvironment, promotes pro-inflammatory T cell...
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Nature Reviews Immunology @natrevimmunol.nature.com · Jun 24
Highlight of a study by Teruyuki Sano and team in @nature.com revealing potential mechanisms by which commensal-specific T cells can contribute to extraintestinal inflammation
#immunosky #microsky #neurosky
Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry - Nature Reviews Immunology
White et al. show that microbiota-specific T cells are licensed by gut inflammation to infiltrate the central nervous system, where cross-reactivity with self-antigens leads to neuropathology.
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