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Reposted by Wen Jiang MD, PhD

Science Magazine @science.org · 10h

This week's new issue of #ScienceTranslationalMedicine is out now!

An experimental trial could reshape patient monitoring and therapy research in glioblastoma, RNA vaccines can protect large animals from new strains of H5N1, and more. https://scim.ag/3KYkXvi

The cover shows a three-dimensional rendering of a brain MRI from a patient with glioblastoma who participated in a clinical trial evaluating an oncolytic virotherapy and testing feasibility of serial biopsy acquisition.

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Aug 7

Our latest article is online @natcancer.nature.com describing the application of #nanotechnology in #immuno-oncology. A great effort led by Adam Grippin, our star Holman resident and soon to be Physician Scientist. @bettykimmdphd.bsky.social @mdanderson.bsky.social @eileenparkes.bsky.social

Nanotechnology for immuno-oncology - Nature Cancer

Kim and colleagues provide an overview of the current state of the art of nanomaterials and their application in immuno-oncology, discussing preclinical development and the clinical landscape.

www.nature.com

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Reposted by Wen Jiang MD, PhD

Rita Strack @ritastrack.bsky.social · Jul 30

My colleagues at Nature Biomedical Engineering @natbiomedeng.nature.com are hiring an associate or senior editor. Ideal applicant will have expertise in immunology, immunotherapy, or immuno-oncology.

Please feel to ask me questions!

springernature.wd3.myworkdayjobs.com/SpringerNatu...

Associate or Senior Editor, Nature Biomedical Engineering

Job Title: Associate or Senior Editor, Nature Biomedical Engineering Organization: Nature Portfolio Location: New York, Jersey City, Shanghai or Beijing – Hybrid Working Closing date: August 20, 2025 ...

springernature.wd3.myworkdayjobs.com

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Jul 26

It also didn’t say if it’s r01, r21, r03, or project lead on spore/p01 etc…just active nih grants. So presumably if you had 2 active r21s, you are pretty much done for?

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Jul 26

I don’t think any NOA has been released from June council. Can your application remain being considered if nci budget later is adjusted as long as it remains pending in era commons?

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Jul 26

it will apply to application reviewed in June nci council too. I don’t think any NOA has been released from that council meeting.

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Jul 26

Does mPI count?

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Jul 23

Congrats to Adam Grippin, a resident in the radiation oncology program @mdanderson.bsky.social , and soon to be physician scientist, on his latest commentary in @natrevimmunol.nature.com, highlighting a new cell surface mapping technique with implication in understanding immune cell functions.

Mitochondrial proteins go public and novel interactions: insights from surfaceome mapping - Nature Reviews Immunology

A recent preprint by Floyd et al. presents the most comprehensive mapping to date of the human lymphocyte ‘surfaceome’.

www.nature.com

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Jun 12

Congrats John!

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Jun 12

Congrats on a new commentary from Ben & @bettykimmdphd.bsky.social @natrevimmunol.nature.com on a preprint detailing a pan-cancer antigen atlas for human cancers. @mdanderson.bsky.social

Uncovering the hidden landscape of tumour antigens - Nature Reviews Immunology

A preprint by Li et al. presents a comprehensive pan-cancer atlas of tumour-specific peptides that markedly expands the known tumour antigen repertoire.

www.nature.com

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · May 14

Our latest publication led by Yifan Wang is now @acs.org on developing a generative #AI #LLM to help design #nanomedicine. @mdanderson.bsky.social @bettykimmdphd.bsky.social

A Generative Artificial Intelligence Copilot for Biomedical Nanoengineering

The recent success of large language models (LLMs) in performing natural language processing tasks has increased interest in applying generative artificial intelligence (AI) to scientific research. Ho...

pubs.acs.org

Reposted by Wen Jiang MD, PhD

Aria Vaishnavi, PhD @drariav.bsky.social · May 9

I am thrilled to share that the first preprint from my lab is now available on bioRxiV! In this study, our team elucidates the role of autocrine ligands in the aberrant behavior of oncogene-driven lung cancer.

www.biorxiv.org/content/10.1...

BRAFV600E-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling

Secretion of ligands of the human epidermal growth factor (EGFR) family of receptors or erythroblastic leukemia viral oncogene family (ERBB1-4) is a feature common to many cancer cells. However, our u...

www.biorxiv.org

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Reposted by Wen Jiang MD, PhD

Nature Reviews Immunology @natrevimmunol.nature.com · May 7

NEW Preprint Watch from Annette Wu & @wenjiang-nano.bsky.social @preprintclub.bsky.social reporting on @biorxiv-immuno.bsky.social preprint by @colinraposo.bsky.social et al. showing that checkpoint blockade drives expansion of exhausted T cell clones that develop functional memory
rdcu.be/ek1kY

Progenitor exhausted T cells contribute to the formation of immunological memory

Nature Reviews Immunology - A preprint by Raposo et al. shows that immune checkpoint blockade drives the expansion of certain clones of exhausted T cells that can develop into functional memory...

rdcu.be

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · May 6

Sharing the latest commentary by our amazing PhD student Annette Wu @natrevimmunol.nature.com previewing exciting work from @stanfordmedicine.bsky.social on the formation of memory T cells in the setting of chronic stimulation. @mdanderson.bsky.social

Progenitor exhausted T cells contribute to the formation of immunological memory - Nature Reviews Immunology

A preprint by Raposo et al. shows that immune checkpoint blockade drives the expansion of certain clones of exhausted T cells that can develop into functional memory cells after clearance of chronic v...

www.nature.com

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Apr 7

Greatly enjoyed @twanlammers.bsky.social visiting Houston! Enjoying some classic Texan protein in preparation for his high caloric burning seminar.

Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Mar 26

Our latest paper in collaboration with @jacques-lux.bsky.social describing using #US to activate #sting for #cancerimmunotherapy is now online in AdvScience. @mdanderson.bsky.social @utswtxid.bsky.social

Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma

This study explores the use of ultrasound contrast agents loaded with Stimulator of Interferon Genes (STING) agonists as an approach to activate the body's immune system against cancer. Termed Microb...

advanced.onlinelibrary.wiley.com

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Mar 5

Research briefing describing our latest paper is now online @naturecancer.bsky.social rdcu.be/ecf1I @mdanderson.bsky.social @ackoongmdphd.bsky.social @bettykimmdphd.bsky.social

An antibody–toxin conjugate enhances innate immune cell responses in tumors

Nature Cancer - Traditional antibody–toxin conjugates (ATCs) are designed to target and destroy cancer cells. We present an ATC that acts on innate immune cells to promote tumor-cell...

rdcu.be

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Reposted by Wen Jiang MD, PhD

MD Anderson Cancer Center @mdanderson.bsky.social · Feb 25

MD Anderson researchers have developed a novel antibody toxin-conjugate that’s not designed to kill the cancer cells directly.

Read how this new approach is designed to trigger the body's natural immune response instead: bit.ly/4bhtToM #EndCancer

MD Anderson researchers develop novel antibody-toxin conjugate

Researchers at The University of Texas MD Anderson Cancer Center have developed a novel antibody-toxin conjugate (ATC) designed to stimulate immune-mediated eradication of tumors. According to preclin...

www.mdanderson.org

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Feb 25

Our newest article is online @naturecancer.bsky.social A new antibody drug conjugate that doesn’t kill tumor cells but rely on immune system to eradicate cancer. @bettykimmdphd.bsky.social @mdanderson.bsky.social

An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy

Nature Cancer - Schrank et al. report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models.

www.nature.com

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Reposted by Wen Jiang MD, PhD

MD Anderson Cancer Center @mdanderson.bsky.social · Feb 19

MD Anderson is grateful to the Cancer Prevention and Research Institute of Texas for providing nearly $23 million to support our ongoing research and faculty recruitment.

Read about the research it will benefit: brnw.ch/21wQOF9 #EndCancer

MD Anderson receives nearly $23 million in CPRIT funding for cancer research, faculty recruitment

The University of Texas MD Anderson Cancer Center today was awarded nearly $23 million from the Cancer Prevention and Research Institute of Texas (CPRIT) in support of 20 cancer research projects to a...

brnw.ch

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Feb 21

Hanging out with old doctoral study advisor in Singapore. Talking about science over beautiful scenery and amazing food.

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Feb 9

I wish I have a magic 8 ball that tells me before hand exactly which experiments that I should conduct that will yield positive results.

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Reposted by Wen Jiang MD, PhD

Nature Reviews Bioengineering @natrevbioeng.nature.com · Dec 19

Understanding how nanoparticles interact with biological systems is crucial for the development and implementation of nanoparticles in clinical settings. This article explores multi-omics approaches to decipher the interactions of nanoparticles and biological systems:
https://go.nature.co...

Multi-omics approaches to decipher the interactions of nanoparticles and biological systems - Nature Reviews Bioengineering

The interactions of nanoparticles with the body are dynamic and complex. This Perspective examines the application of different multi-omics tools to investigate nano–bio interactions in vitro and in vivo.

go.nature.com

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Reposted by Wen Jiang MD, PhD

Albert Koong @ackoongmdphd.bsky.social · Jan 12

Congrats to @wenjiang-nano.bsky.social! Well deserved recognition. @MDAndersonNews #endcancer #radonc

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Wen Jiang MD, PhD @wenjiang-nano.bsky.social · Dec 18

Finishing up 2024 with our latest paper in Nature Rev Bioengineering on using multiomic tools to study bio-nano interactions. @bettykimmdphd.bsky.social @mdanderson.bsky.social

Multi-omics approaches to decipher the interactions of nanoparticles and biological systems - Nature Reviews Bioengineering

The interactions of nanoparticles with the body are dynamic and complex. This Perspective examines the application of different multi-omics tools to investigate nano–bio interactions in vitro and in v...

www.nature.com

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