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Seth Thomas Scanlon @immunoeditor.bsky.social · 2d

Thanks, @natrevimmunol.nature.com, for highlighting this exciting recent paper in #Science #Immunology!

Nature Reviews Immunology @natrevimmunol.nature.com · 2d

Highlight of Science Immunology paper by @thepenkpanther.bsky.social, Alexander Rudensky and colleagues @mskcancercenter.bsky.social @scripps.edu @wcm-imp.bsky.social
#immunology #immunosky #neurosky

Skin Treg cells set the tone for neuronal activation - Nature Reviews Immunology

A study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their production of the opioid enkephalin.

www.nature.com

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Seth Thomas Scanlon @immunoeditor.bsky.social · 4d

This week in #Science #Immunology! 👇

Kilian Schober @kischober.bsky.social · 4d

If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

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Seth Thomas Scanlon @immunoeditor.bsky.social · 4d

The October issue of #Science #Immunology is out now! This week: how #TCR avidity shapes #CD8 #TCell responses to #mRNA #vaccines and the latest research on the immunology of #brain #tumors reviewed! New content added every week!

scim.ag/46TGooP

Decoding the Brain Tumor Immune Microenvironment. Brain tumors originate either from within the brain or as metastases from other tissues and pose major clinical challenges because of their heterogenous and aggressive nature. Bunse et al. review the cellular and molecular determinants of brain tumor antigenicity and factors that contribute to the immunosuppressive brain tumor microenvironment (TME). This month’s cover illustration depicts distinct malignant glioma (upper left) and metastatic (bottom right) TMEs as collages of aperiodic penrose tiles overlaid on a stylized positron emission tomography (PET) scan of the brain.
Credit: Rioka Hayama

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Seth Thomas Scanlon @immunoeditor.bsky.social · 8d

David Baker & colleagues develop an #IL21 mimic (21h10) that is more stable & shows x-reactivity against both human & murine #IL21R. 21h10 promotes potent antitumor responses in mice and in human #melanoma tumor explants, expanding low-affinity CD8 #TCells & #TH1 cells & reducing #Tregs in #tumors!

Design of a potent interleukin-21 mimic for cancer immunotherapy

A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.

www.science.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · 8d

Now in #Science #Immunology: Deshpande, Klose, & al at Charité—Universitätsmedizin Berlin report that #ILC2 resident in #PNS communicate with neurons via #IL13 to maintain #nerve structure & pain thresholds. Mice lacking ILC2 or whose neurons are Il4ra-KO exhibit #hypersensitivity & #gait defects!

Group 2 innate lymphoid cells regulate nociceptive and gait functions of the peripheral nervous system

ILC2-neuron cross-talk contributes to the maintenance of nerve structure and function of the peripheral nervous system.

www.science.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · 8d

Out now in #Science #Immunology: Zhenghai Tang (U of Macau) & André Veillette (@ircm.bsky.social / @mcgill.ca / @umontreal.ca) review the latest research on inhibitory #ImmuneCheckpoints in #cancer #immunotherapy. Check it out!

Inhibitory immune checkpoints in cancer immunotherapy

Inhibitory immune checkpoints for cancer immunotherapy are reviewed.

www.science.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · 18d

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

Nuclear polarization to the immune synapse facilitates an early transcriptional burst

Cytotoxic T lymphocyte target recognition triggers rapid nuclear polarization to the immune synapse and an early transcriptional burst of cytokines.

www.science.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · 18d

Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins

Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

www.science.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · Sep 5

The September issue of #Science #Immunology is out! This week: METTL1 m⁷G RNA modification of NAD+ #metabolism → #macrophage -mediated #inflammation; proenkaphalin+ #Tregs restrain skin inflamm via control of #nociception; #RNA helicase DDX55 is regulator of naïve #TCell homeostasis

scim.ag/3HKC5DP

Shining a Light on Naïve T Cell Homeostasis:

Homeostatic maintenance of naïve T cells is critical to maintain a large and diverse T cell pool. However, the underlying mechanisms regulating this process are not well understood. Wu et al. report that the RNA helicase DDX55 regulates the homeostatic maintenance of naïve T cells by preventing MYC from binding to enhancer- and promoter-like transposable elements (TEs) near T cell activation genes. In naïve T cells, DDX55 prevents the inappropriate activation of TEs and ensures their genomic stability by preventing R-loop formation. This month’s cover features a light bulb with its filament stylized as a DNA double helix. Its left half glows with an intact filament, symbolizing TEs as regulators, and its right side is dimmed and features a broken filament, representing TEs’ disruptive potential.
Credit: Bingyu Yang and Jianling Zhu/Sichuan University

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Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 30

Way to go, @cnfogg.bsky.social!

Christie Wilcox @nerdychristie.bsky.social · Aug 29

In this edition of #ScienceAdviser, Science Immunology Senior Editor @cnfogg.bsky.social talks about how her love of running led her to be the subject of science—rather than the editor of it. Plus more of the best from @science.org and science: www.science.org/content/arti... 🧪

Christiana Fogg, 11.7 miles into the 2024 Stone Mill 50-miler. Photo: Dan Reichmann, MCRRC

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Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 29

Heads up: @science.org is looking for a new research #editor based in the US or UK to handle papers in #InfectiousDiseases (e.g., #virology, #microbiology, #parasitology) & #microbiome research! This is an amazing opportunity, so don't delay! Applications are due 22 SEP!

recruiting.ultipro.com

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Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 15

Heads up: @science.org 's immunology editor @sarahhross.bsky.social and I will both be attending the @iuis-online.bsky.social 19th International Congress next week in the ever enchanting city of #Vienna! We hope to see many of you there!

Home - IUIS 2025

IUIS 2025 ACCREDITED WITH 26 CME CREDITSThe 19th International Congress of Immunology (IUIS 2025), Vienna, Austria 17/08/2025 – 22/08/2025, has been accredited by the European Accreditation Council fo...

iuis2025.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 12

The cover was illustrated by Rioka Hayama, who also designed #Science #Immunology 's wicked JAN 2025 cover!

riokahayama.com

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Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 12

This week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover!

scim.ag/3UqRrA6

COVER This illustration depicts the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age. The infant silhouette contains DNA, and the figures are enveloped by the nuclear and plasma membranes. These components reference the evolution of immunity over millennia, as viruses integrated into the genome and as life progressed from single-celled to multicellular organisms. See the special section beginning on page 586.

Illustration: Rioka Hayama

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Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 1

The cover depicts an hourglass with beneficial (blue) & pathogenic (orange) microbiota drawn as sand. Transferred Tregs lining the hourglass cause the “sand” to flow in reverse, highlighting their ability to undo some of the effects of inflammaging by restoring gut barrier integrity!

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Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 1

This week's cover, illustrated by the amazing Ashley Mastin, highlights work by @mmgomezheras.bsky.social & al.!

CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging.

www.science.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · Aug 1

The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!

wwwscience.org/toc/sciimmun...

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Seth Thomas Scanlon @immunoeditor.bsky.social · Jul 17

Out now in #Science #Immunology: Eric Vivier (@univ-amu.fr), Hui Peng, Zhigang Tian (USTC, Hefei), & colleagues report that #FetalLiver #InnateLymphoidCell ( #ILC ) progenitors in mice continue contributing to ILC #hematopoiesis into adulthood in a #BoneMarrow –independent manner!

Innate lymphoid cells originate from fetal liver–derived tissue-resident progenitors

Fetal liver–derived ILC progenitors seed peripheral tissues and generate local ILCs independently of the bone marrow throughout life.

www.science.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · Jul 4

These 2 processes together fine-tune #type2 immune responses & may help explain why, for example, #IgE sensitization & development of #allergic disorders are more prevalent in males & certain groups with groups sharing genetic ancestry.

#SexDifferences in #Immunity
#HumanImmunology
#RTEexonization

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Seth Thomas Scanlon @immunoeditor.bsky.social · Jul 4

In #Science #Immunology, @tobiasplowman.bsky.social, Kassiotis, & al report canonical #IL13RA1 expression is negatively regulated by E2 #estrogen & also describe a primate-specific RTE-derived IL-13Rα1 isoform that antagonizes the canonical receptor & attenuates responsiveness to #IL4 and #IL13!

Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses

Co-option of primate-specific retroelements creates an alternative IL-13Rα1 subunit that tunes type 2 immune responses.

www.science.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · Jul 4

The July issue of #Science #Immunology is out now! This week:

• Additional levels of #IL13RA1 gene regulation help explain susceptibility to #allergy!

• Spi-B is a #checkpoint of #type2 immunity by restraining #TuftCell activation in gut!

New content each week!

www.science.org/toc/sciimmun...

Checkpoint on Type 2 Immunity. Tuft cells play key roles in the initiation and propagation of type 2 immune responses in the gut, but whether they have regulatory machinery for constraining these responses is not known. Wang et al. found that the transcription factor Spi-B prevents excessive type 2 immune responses against helminth infection and food allergens by limiting tuft cell activation and proliferation in the small intestine. Spi-B represses c-Kit signaling in tuft cells, which limits their production of the cytokine TSLP and the subsequent activation of T helper 2 (TH2) cells. This month’s cover image features a tuft cell (dark red) within the epithelial lining of the small intestine in which Spi-B has been inactivated, leading to increased production of TSLP by tuft cells and the cytokine interleukin-13 (IL-13) by TH2 cells (white).

Credit: A. Fisher/Science Immunology

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Seth Thomas Scanlon @immunoeditor.bsky.social · Jun 27

I am so delighted to be in #Japan for this year's RIKEN IMS–JSI International Symposium on #Immunology! 🇯🇵

温かく迎えてくれた主催者に感謝する！

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Seth Thomas Scanlon @immunoeditor.bsky.social · Jun 25

To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025

bit.ly/SciImm_free

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Seth Thomas Scanlon @immunoeditor.bsky.social · Jun 20

Out now in #Science #Immunology: using a forward genetic of #ion #channels & #transporters, @stefanfeske.bsky.social & colleagues identified chloride nucleotide-sensitive channel 1A (CLNS1A) to be a critical regulator of #CD4 #TCell proliferation & differentiation!

CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity

CLNS1A promotes autoimmunity through epigenetic and transcriptional regulation of DNA repair and cell cycle progression in CD4 T cells.

www.science.org

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Seth Thomas Scanlon @immunoeditor.bsky.social · Jun 20

Recently in #Science #Immunology: Van der Veeken & al @ IMP @viennabiocenter.bsky.social generated 🐁 w auxin-inducible degradable #Foxp3! Tissue #Tregs minimally unaffected @ homeostasis but highly dependent on continuous Foxp3 activity in models of #autoimmunity, #viral #infection, & #cancer !

Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3

Acute Foxp3 protein depletion selectively affects Treg cells responding to type 1 inflammation.

www.science.org

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