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Rockefeller University Press @rupress.org · 4h

New @jcb.org study from Swift, Pustova, Audhya et al. @uwmadison.bsky.social defines the native dynamics of the ESCRT-III component Ist1 in mammalian cells, highlighting the existence of multiple, unique pools at #endosomes. rupress.org/jcb/article/...

#membrane #lipid

Rockefeller University Press @rupress.org · 1d

New in @jhumimmunity.org: Noori et al. use recently developed in vitro technology to define the function of a previously uncharacterized STX11 mutation L135P in a patient w/ atypical familial hemophagocytic lymphohistiocytosis. rupress.org/jhi/article/...
@petermaccc.bsky.social

Partial STX11 deficiency due to a hypomorphic variant—self-limiting inflammatory disease preceding HLH onset | Journal of Human Immunity | Rockefeller University Press

Recently developed in vitro technology was used to define the function of a previously uncharacterized STX11 mutation L135P present in a patient with atypi

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Rockefeller University Press @rupress.org · 1d

Xu et al show in @jem.org that the cGAS-TREX1 axis forms a critical feedback loop in MSI-H/dMMR tumors. Trex1 loss amplifies tumor-intrinsic cGAS–STING signaling & activates CD8+ T cell–mediated antitumor immunity, highlighting TREX1 inhibition’s therapeutic potential

Tumors with microsatellite instability upregulate TREX1 to escape antitumor immunity

This study demonstrates that the cGAS-TREX1 axis forms a critical negative feedback loop, enabling immune evasion in MSI-H/dMMR tumors. They revealed that

rupress.org

Rockefeller University Press @rupress.org · 1d

In @jgp.org, Scala et al @colinnicholslab.bsky.social assess #SkeletalMuscle properties in gain-of-function knock-in mouse models of Cantu Syndrome. Isolated SUR2 GOF, but not Kir6.1 GOF muscles show enhanced fatiguing that was reversed by the KATP inhibitor glibenclamide

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

We assessed skeletal muscle properties in GOF knock-in mouse models of Cantu Syndrome. In isolated myofibers there was enhanced Mg-nucleotide activation in

rupress.org

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Rockefeller University Press @rupress.org · 1d

In @jgp.org, Scala et al @colinnicholslab.bsky.social assess #SkeletalMuscle properties in gain-of-function knock-in mouse models of Cantu Syndrome. Isolated SUR2 GOF, but not Kir6.1 GOF muscles show enhanced fatiguing that was reversed by the KATP channel inhibitor glibenclamide

Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice

We assessed skeletal muscle properties in GOF knock-in mouse models of Cantu Syndrome. In isolated myofibers there was enhanced Mg-nucleotide activation in

rupress.org

Rockefeller University Press @rupress.org · 1d

In @jgp.org, Sonia Carolina Guerrero Prieto, Michael Cabrera Baez, & Rubem Carlos Araújo Guedes reveal that dopaminergic signaling influences cortical excitability and cortical spreading depression dynamics, offering new mechanistic insights into dopamine’s cortical role.

Cortical spreading depression dynamics are altered by topical D2 receptor ligands

Topical application of D2 receptor ligands modulates CSD propagation in a ligand- and time-dependent manner. Electrophysiological and immunohistochemical a

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Rockefeller University Press @rupress.org · 2d

Congratulations to @jem.org advisory editor Shimon Sakaguchi, along with Mary Brunkow and Fred Ramsdell, on winning the 2025 #Nobel Prize in Physiology or Medicine for their groundbreaking discoveries on peripheral immune tolerance

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

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Rockefeller University Press @rupress.org · 2d

In @jhumimmunity.org Tiago Santos de Oliveira, Antonio Condino-Neto et al. describe #CGD #epidemiology in Latin America, highlighting high infection risks, limited treatment options, & poor survival rates, esp. for males w/ XL-CGD rupress.org/jhi/article/...

@lasidofficial.bsky.social

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Rockefeller University Press @rupress.org · 2d

@jcb.org's October issue is out! rupress.org/jcb/issue/22...
The cover shows early postnatal mouse cortex w/ #astrocytes (magenta) & their #mitochondria (green) in a model of inhibited astrocytic mitochondrial fission. See Rodriguez Salazar @caglaeroglu.bsky.social et al rupress.org/jcb/article/...

Rockefeller University Press @rupress.org · 2d

@jem.org's October issue is here! rupress.org/jem/issue/22...
The cover image shows the lung of a mouse infected with M. #tuberculosis stained for #neutrophils (orange) normal lung parenchyma (blue), collagen (white) & CD4 T cells (green). See @bengern.bsky.social et al rupress.org/jem/article/...

Rockefeller University Press @rupress.org · 5d

#Macrophages are presumed to attack antibody-opsonized #cancer cells by #phagocytosis. In @jcb.org, @kirstin-rollins.bsky.social, @mmorrissey.bsky.social et al find that macrophages attack adherent cells using #trogocytosis, or cell nibbling, instead of phagocytosis. rupress.org/jcb/article/...

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Rockefeller University Press @rupress.org · 5d

New in @jgp.org: Zangerl-Plessl, Lee, et al. utilized MD simulations to reveal that PIP2 potentiated clockwise twisting motions in individual Kir2 #IonChannel cytoplasmic subunits, as well as concerted dynamics among the four subunits. rupress.org/jgp/article/...
@colinnicholslab.bsky.social

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Rockefeller University Press @rupress.org · 6d

Join @jcb.org Scientific Editor Gabriele Stephan at the EMBO | EMBL Symposium “Cell biology of the nucleus” during the lunchtime Meet the Editor talk November 19. www.embl.org/about/info/c... #EESNucleus @events.embl.org

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Rockefeller University Press @rupress.org · 7d

New in @jhumimmunity.org: Svetlana Vakkilainen reviews 60 years of cartilage-hair hypoplasia research, covering genetic aspects, pathogenesis, clinical & laboratory features, as well as diagnostic & management considerations rupress.org/jhi/article/...

#InbornErrorsOfImmunity

Rockefeller University Press @rupress.org · 8d

New in @jcb.org: Wenjing Long, Yanshan Fang et al. reveal that an SCFFBXO21 E3 #ubiquitin ligase complex ubiquitinates NMNAT2 at K155 & promotes its turnover in neurons & show that Fbxo21 deficiency confers axonal protection both in vitro & in vivo rupress.org/jcb/article/...
#Neuroscience

Rockefeller University Press @rupress.org · 8d

Zhu, Lu, Veillette et al. @ircm.bsky.social show in @jem.org that CD2 & its ligands regulate #MAITcell development and antigen responses by enhancing TCR signaling. A natural subset of human MAIT cells lacking CD2 exhibits reduced activation responses to antigen. rupress.org/jem/article/...

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Rockefeller University Press @rupress.org · 8d

New in @jhumimmunity.org: Tristan van der Linden, András Spaan et al. describe and characterize six unrelated patients with #OTULIN #haploinsufficiency, in whom severe #necrosis followed infectious and/or traumatic triggers. rupress.org/jhi/article/...

#Staphylococcus #Ubiquitin

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Rockefeller University Press @rupress.org · 8d

@jem.org is pleased to present a special collection highlighting recent findings in the #InnateImmunity field. It spotlights cutting-edge research on the mechanistic aspects of innate immune signaling upon #infection, in #autoimmunity, and in #neurodegeneration.

rupress.org/jem/collecti...

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Rockefeller University Press @rupress.org · 9d

In this @jhumimmunity.org Perspective, Farida Almarzooqi & Ahmed Aziz Bousfiha propose universal genomic screening as a life-course strategy, using Mendelian susceptibility to #mycobacteria as a model to demonstrate feasibility in high-consanguinity populations

Toward universal screening for disease-causing alleles: Mendelian susceptibility to mycobacterial disease as a model | Journal of Human Immunity | Rockefeller University Press

This Perspective proposes universal genomic screening as a life-course strategy, using Mendelian susceptibility to mycobacterial disease as a model to demo

rupress.org

Rockefeller University Press @rupress.org · 9d

Dolichol-linked oligosaccharide (DLO) is the precursor for asparagine-linked protein #glycosylation. In @jcb.org, Sheng-Tao Li, Tadashi Suzuki et al. identify a DLO-pyrophosphatase (Llp1), which is involved in DLO homeostasis/quality control. rupress.org/jcb/article/...

Rockefeller University Press @rupress.org · 12d

Congratulations to @jem.org Editorial Board Co-Chair Carl Nathan on receiving the 2025 David & Beatrix Hamburg Award from @nam.edu for his fundamental work in improving understanding of #InnateImmunity:

National Academy of Medicine to Present Hamburg Award to Carl F. Nathan for Seminal Discoveries That Improve Understanding of Innate Immunity - NAM

WASHINGTON — The National Academy of Medicine (NAM) today announced that Carl F. Nathan is the recipient of the 2025 David and Beatrix Hamburg Award for

nam.edu

Rockefeller University Press @rupress.org · 12d

A previous report described an inherited deficiency of IL-18BP in an Algerian patient who died of fulminant viral hepatitis (FVH) A. Abd Elaziz et al. report in @jhumimmunity an Egyptian family with two siblings who died from FVH following infection w/ hepatitis A virus

Inherited IL-18BP deficiency in two Egyptian siblings with fulminant viral hepatitis | Journal of Human Immunity | Rockefeller University Press

A previous report described an inherited deficiency of IL-18BP, a soluble antagonist of IL-18, in an Algerian patient who died of fulminant viral hepatitis

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Rockefeller University Press @rupress.org · 13d

In @jem.org, Tao Han, Chenchen Ruan, Jiahuai Han, Yingying Zhang et al reveal that RIPK1 S161 autophosphorylation promotes further autophosphorylation & is sufficient to substitute for RIPK1 kinase activity in TNF-induced necroptosis-mediated cecal damage & mouse death. rupress.org/jem/article/...

Rockefeller University Press @rupress.org · 13d

In @jem.org, Lioba Koerner, Xiaoming Li, Lucie Laurien, Manolis Pasparakis et al. show that RIPK1 autophosphorylation at S161 is crucial for regulating cell death and #inflammation. rupress.org/jem/article/...

Rockefeller University Press @rupress.org · 13d

Paul Kubes & Daniel Mucida are @jem.org Academic Editors! Paul studies how myeloid cells integrate into healthy tissues & maintain homeostasis at Queen's University. Daniel studies how gut immune system balances response & tolerance at @rockefelleruniv.bsky.social - bios: rupress.org/jem/pages/ed...

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