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Jarrod Dudakov @dudakov-lab.bsky.social · 10h

Finally some press that this policy goes way beyond the tech sector - which does dominate H1B numbers - but is also crucial for medicine and research too. Death by a thousand open wounds.

Thiago Carvalho @cyrilpedia.bsky.social · 13h

“Most of these positions aren’t positions for which we can hire domestically,” (Dr. Martin ) said, pointing to, for example, America’s shortage of anesthesiologists'

Trump’s H-1B Visa Fee Could Strain Universities and Schools

www.nytimes.com

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Reposted by Jarrod Dudakov

bioRxiv Immunology @biorxiv-immuno.bsky.social · 20h

Secondary lymphoid organ endothelial cells prime alloreactive CD4+ T cells to trigger acute graft-versus-host disease https://www.biorxiv.org/content/10.1101/2025.10.07.677751v1

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Jarrod Dudakov @dudakov-lab.bsky.social · 2d

Absolutely: checkpoints, self-recognition, and now Tregs all getting up but the discovery of the cellular mediators (and where they come from) continually snubbed. Was told to me that the Robert Good tolerance fiasco may have tainted the field as he would likely have been included in a thymus gong.

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Jarrod Dudakov @dudakov-lab.bsky.social · 2d

Preach. Quite possibly apocryphal, but I had heard that the work was tainted by the likely third member that may have gotten the nod, who was tarnished by the painted mice fiasco. www.nytimes.com/1974/05/25/a...

lnquiry at Cancer Center Finds Fraud in Research (Published 1974)

www.nytimes.com

Jarrod Dudakov @dudakov-lab.bsky.social · 2d

Close, but no cigar. I do hope it happens soon, I fear we are running out of time for Jacques to be recognized!

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Jarrod Dudakov @dudakov-lab.bsky.social · 2d

No arguments here!

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Jarrod Dudakov @dudakov-lab.bsky.social · 2d

Great primer. Also great to see peripheral tolerance recognized, but I will note you can’t get tregs without central tolerance and the thymus! Miller snubbed again!

Adrian Liston @labliston.bsky.social · 2d

A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine

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Reposted by Jarrod Dudakov

Waggoner Lab @labwaggoner.bsky.social · 11d

Review @cp-trendsimmuno.bsky.social Decoding immune aging at single-cell resolution
cell.com/trends/immun...

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Reposted by Jarrod Dudakov

Waggoner Lab @labwaggoner.bsky.social · 12d

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression @nataging.nature.com
www.nature.com/articles/s43...

A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression - Nature Aging

Bodogai et al. identify a unique subset of CD8+ T cells expressing CD39 and CD73 that accumulate during aging and are recruited to and actively promote tumor progression by suppressing antitumor CD4+ T cells. Targeting their function or recruitment attenuates tumor growth in aged mice.

www.nature.com

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Jarrod Dudakov @dudakov-lab.bsky.social · 13d

Amazing. (I really hope we don’t find out this is AI)

Rebecca R Helm @rebeccarhelm.bsky.social · 14d

I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA

10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)

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Reposted by Jarrod Dudakov

Harmit Singh Malik @harmitmalik.bsky.social · 18d

Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.

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Jarrod Dudakov @dudakov-lab.bsky.social · 19d

Yes, please! Will be trying this out soon. (Well, someone in the lab will be trying this soon!).

Adrian Liston @labliston.bsky.social · 19d

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

currentprotocols.onlinelibrary.wiley.com

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Reposted by Jarrod Dudakov

Waggoner Lab @labwaggoner.bsky.social · 19d

@biorxivpreprint.bsky.social efineptakin alfa (NT-I7), a long-acting form of IL-7, induce beneficial stem-like CD8 T cell-supporting tertiary lymphoid structures enriched for PD-L1 in murine lung tumor model
biorxiv.org/content/10.1...

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Jarrod Dudakov @dudakov-lab.bsky.social · 24d

Great piece. Now extrapolate across the other 26 institutes and every disease/biological process you can conceive.

The New York Times @nytimes.com · 24d

“It will take decades to recover from this, if we ever do.” America’s cancer research system, which has helped save millions of lives and is in one of its most productive moments, is under threat by the Trump administration.

Trump Is Shutting Down the War On Cancer

America’s cancer research system, which has helped save millions of lives, is under threat in one of its most productive moments.

nyti.ms

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Reposted by Jarrod Dudakov

Blood Journals' Portfolio @bloodjournals.hematology.org · 24d

Inflammatory memory of stem cells: implications for hematologic diseases buff.ly/QBUFcjd #hemesky

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Reposted by Jarrod Dudakov

Waggoner Lab @labwaggoner.bsky.social · 26d

Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate

Tcf1 and Lef1 prime prethymic progenitors for Notch responsiveness, promoting early thymic progenitor fate and lineage stability.

www.science.org

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Reposted by Jarrod Dudakov

American Society of Hematology @ash.hematology.org · 27d

ASH applauds the House and Senate Appropriations Committees for rejecting proposed NIH cuts but urges Congress to also protect critical CDC programs supporting individuals with blood disorders.

🔗 https://bit.ly/41PqLNv

#Fight4Hematology #ResearchSavesLives #HemeSky

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Reposted by Jarrod Dudakov

Waggoner Lab @labwaggoner.bsky.social · 27d

Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration
www.nature.com/articles/s41...
@natimmunol.nature.com @dudakov-lab.bsky.social @fredhutch.bsky.social

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Jarrod Dudakov @dudakov-lab.bsky.social · 27d

Shoutout also to our magnificent funders NIA, NHLBI, NIAID and Dr Stephanie Houston who was our amazing editor at @natimmunol.nature.com who made the process (relatively) painless!

a man with long hair and a beard is smiling and saying thank you .

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media.tenor.com

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Jarrod Dudakov @dudakov-lab.bsky.social · 27d

Of course, none of this could have happened without the tireless work of David; tremendous support from the rest of the lab (especially Makya Warren, Kirsten Cooper, Dante Acenas); as well as Anastasia Kousa and @andrilemarquis.bsky.social who provided essential sequencing and parabiosis data!

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Jarrod Dudakov @dudakov-lab.bsky.social · 27d

However, the question remains: does this happen for a reason (for instance, pruning of the damaged TEC compartment) or is it a byproduct of the cellular turmoil after acute insult?

a fat man is wearing a blue and yellow striped shirt .

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media.tenor.com

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Jarrod Dudakov @dudakov-lab.bsky.social · 27d

Moreover, despite the increase in IFNg, we also found that thymic epithelial cells (TECs) actually decreased their MHCI expression after damage, making them vulnerable to NK-mediated killing. Given the central importance of TECs for all thymic function, their killing after damage inhibits repair.

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Jarrod Dudakov @dudakov-lab.bsky.social · 27d

But to our surprise, although upregulated in response to IL-18, this inhibitory effect was not mediated by IFNg. Instead, both perforin and granzyme could limit thymic regeneration, but only perforin was regulated by IL-18.

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Jarrod Dudakov @dudakov-lab.bsky.social · 27d

Using a slew of mouse strains and assays including imaging, single-cell sequencing, parabiosis, and more, David found that IL-18 released by hematopoietic (DC/macrophage) and non-hematopoietic (mesothelial) cells activated NK cells (but not ILC1) limiting repair via their cytotoxic function.

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Jarrod Dudakov @dudakov-lab.bsky.social · 27d

However, while mice deficient for IL-1 signaling showed no phenotype, those deficient for IL-18 exhibited significantly improved recovery, suggesting that IL-18 plays a suppressive role in thymic repair. Once we had this finding, David was off to the races to uncover all the mechanistic details.

a group of south park characters standing in front of a brick wall with the words " there might be something to this "

ALT: a group of south park characters standing in front of a brick wall with the words " there might be something to this "

media.tenor.com

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