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Kuchroo Lab @kuchroolab.bsky.social · 28d

#KuchrooLabReunion at #CSNeuroimmune25 in NYC with VKK & Manu Rangachari

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Kuchroo Lab @kuchroolab.bsky.social · Aug 25

This conference is going to be great!
Looking forward to it.

RTN Conference @rtnconference.bsky.social · Aug 25

#ReThinkNeuroimmunology!
3 days
27 speakers
7 selected talks
2 panel discussions
>400 registered
Submit your abstract by August 28th for #RTN2025.
🔗 genelayinstitute.org/rtn/ 🧪
@quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua

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Kuchroo Lab @kuchroolab.bsky.social · Aug 25

This conference is going to be great! Looking forward to it.

Reposted by Kuchroo Lab

The Gene Lay Institute of Immunology and Inflammation @genelayinstitute.bsky.social · Aug 18

Blockade of STUB1 in T cells boosts anti-tumor immunity. Study from the #SharpeLab led by @martinlafleur.bsky.social & #LaurenMilling @natimmunol.nature.com.
@genelayinstitute.bsky.social @harvardmed.bsky.social @broadinstitute.org
hms.harvard.edu/news/researc...
www.nature.com/articles/s41...

Research Identifies New Ways To Supercharge Cancer Immunotherapy

Findings, based on mouse studies, could pave the way for more effective cancer treatments

hms.harvard.edu

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Reposted by Kuchroo Lab

Waggoner Lab @labwaggoner.bsky.social · Aug 13

REV-ERBα & REV-ERBβ, which control clock gene expression, also maintain ILC3 in a state that facilitates the maintenance of a balanced and healthy intestine @natimmunol.nature.com #ColonnaLab
www.nature.com/articles/s41...
preview @theonlylabever.bsky.social
www.nature.com/articles/s41...

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Reposted by Kuchroo Lab

The Gene Lay Institute of Immunology and Inflammation @genelayinstitute.bsky.social · Jul 31

🚨 New study from the lab of our Vice Director, Arlene Sharpe, led by @kepauken.bsky.social & #SamuelMarkson in @jem.org.
PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪

Journal of Experimental Medicine @jem.org · Jul 24

@kepauken.bsky.social, Markson, Sharpe et al. @harvardmed.bsky.social show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/...

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Reposted by Kuchroo Lab

The Gene Lay Institute of Immunology and Inflammation @genelayinstitute.bsky.social · Jul 31

Cellular & spatial profiling of fibrosis in Crohn's disease provides new insights into the mechanisms involved.
From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab.
Study led by #LingjiaKong @broadinstitute.org

Nature Genetics @natgenet.nature.com · Jun 27

📢ONLINE @natgenet.nature.com

📰Single-cell and spatial transcriptomics of stricturing #Crohn’s disease highlights a fibrosis-associated network.

By Lingjia Kong, ‪@thexavierlab.bsky.social‬ and colleagues.

⬇️

www.nature.com/articles/s41...

Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network - Nature Genetics

Single-cell and spatial transcriptomics analysis of stricturing Crohn’s disease highlights cellular heterogeneity in fibrotic tissue and identifies neighborhoods of fibroblasts and immune cells contri...

www.nature.com

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Reposted by Kuchroo Lab

Michael D Kornberg @mdkornberg.bsky.social · Jul 29

New work from the lab - we found a surprising role for the glycolytic enzyme PGAM in Treg function. Whereas most glycolytic enzymes support inflammatory T cells, PGAM has the opposite effect by controlling serine synthesis to regulate the Treg-Th17 axis. #immunometabolism doi.org/10.7554/eLif...

Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanc...

doi.org

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Reposted by Kuchroo Lab

Michael D Kornberg @mdkornberg.bsky.social · Jul 29

Gratifyingly, our findings complement and corroborate a very cool recent story from @kuchroolab.bsky.social showing that PGAM activity negatively regulates pathogenic Th17 cells www.sciencedirect.com/science/arti...

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity

Glucose metabolism is a critical regulator of T cell function, largely thought to support their activation and effector differentiation. Here, we inve…

www.sciencedirect.com

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Reposted by Kuchroo Lab

The Gene Lay Institute of Immunology and Inflammation @genelayinstitute.bsky.social · Jul 17

Our annual symposium on Immunity & Inflammation in Disease & Tissue is on again on August 6th.
🎙️Looking forward to talks from #RafiAhmed, #RichardFlavell, @thefuchslab.bsky.social, #BanaJabri & #LawrenceSteinman.
Joseph B. Martin Conference Center, Boston MA

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Reposted by Kuchroo Lab

RTN Conference @rtnconference.bsky.social · Jun 12

Have you registered yet for #ReThinkNeuroimmunology in October?
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more

RTN Conference @rtnconference.bsky.social · Apr 23

#ReThinkNeuroimmunology
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/

RTN Conference @rtnconference.bsky.social · Apr 17

[email protected] @weizmanninstitute.bsky.social @genelayinstitute.bsky.social @massgenbrigham.bsky.social

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Kuchroo Lab @kuchroolab.bsky.social · Jun 6

The glycolytic enzyme, phosphoglycerate mutase (PGAM), is a key metabolic regulator suppressing Th17 cell pathogenicity & autoimmunity.
Led by Chao Wang, Allon Wagner & Johannes Fessler, with #Yoseflab, our study is now published @cp-cellreports.bsky.social 🔗 www.cell.com/cell-reports...

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity

Wang et al. identify phosphoglycerate mutase (PGAM) as a negative regulator of pathogenic Th17 cell differentiation, contrary to other glycolytic enzymes. PGAM inhibition suppresses a regulatory progr...

www.cell.com

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Reposted by Kuchroo Lab

Waggoner Lab @labwaggoner.bsky.social · Jun 6

The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity @cp-cellreports.bsky.social @kuchroolab.bsky.social
www.cell.com/cell-reports...

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Kuchroo Lab @kuchroolab.bsky.social · Jun 3

Grad student, #RockyBarilla was responsible for driving this huge effort. Well done!

Kuchroo Lab @kuchroolab.bsky.social · May 23

🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense

Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

www.science.org

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Reposted by Kuchroo Lab

thexavierlab.bsky.social @thexavierlab.bsky.social · May 30

(1/6) Our latest paper in ‪@cp-cellhostmicrobe.bsky.social‬ shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway.
www.cell.com/cell-host-mi...

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00186-6‬

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Reposted by Kuchroo Lab

Samuel A. Myers' lab @samyers-lab.bsky.social · May 29

Come join us next week to hear @kuchroolab.bsky.social talk about exciting new work @lji.org

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Reposted by Kuchroo Lab

thexavierlab.bsky.social @thexavierlab.bsky.social · May 27

Out now in @Science! We and the @kuchroolab.bsky.social described responses of enteric neurons to inflammatory cues during infection, showing that primary sensory neurons detect type 2 cytokines, balance neuropeptides, and influence site-specific immunity

www.science.org/doi/10.1126/...

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense

Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

www.science.org

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Kuchroo Lab @kuchroolab.bsky.social · May 23

We show that Th2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven clearance of gut pathogens🪱🪱.

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Kuchroo Lab @kuchroolab.bsky.social · May 23

🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱.
🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org
www.science.org/doi/10.1126/...

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense

Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

www.science.org

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Reposted by Kuchroo Lab

Waggoner Lab @labwaggoner.bsky.social · May 22

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense
www.science.org/doi/10.1126/...
@science.org @kuchroolab.bsky.social @thexavierlab.bsky.social

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Reposted by Kuchroo Lab

The Gene Lay Institute of Immunology and Inflammation @genelayinstitute.bsky.social · May 22

New research from @quintanalabhms.bsky.social show how glioblastoma co-opts TRAIL-positive astrocytes to suppress anti-tumor T cell function. Now published @nature.com
www.nature.com/articles/s41...

Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity - Nature

A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve o...

www.nature.com

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Reposted by Kuchroo Lab

The Gene Lay Institute of Immunology and Inflammation @genelayinstitute.bsky.social · May 12

So great that Brenda & Jason gave us daily recaps of their favorite talks at #AAI2025 via @immunologypodcast.com.
🌟Episode 5 features a talk by Ana Anderson on how opioids drive immunosuppression in T cells in cancer.
Listen to all the episodes for highlights from the🧪 @aai.org conference👇

Immunology Podcast @immunologypodcast.com · May 12

What a week!

#ICYMI, Brenda and Jason attended #IMMUNOLOGY2025 in Honolulu and summarized the research presented each day.

Listen to the episode series here: bit.ly/4jR106q

@aai.org #AAI2025

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Reposted by Kuchroo Lab

Harvard Brain Science Initiative @harvardbrainsci.bsky.social · May 8

A new study raises the odds that a strategy already successful against some cancers may be deployed against Alzheimer’s.
From @kuchroolab.bsky.social and colleagues, co-first authors Kimitoshi Kimura and @ayshwaryas.bsky.social
news.harvard.edu/gazette/stor...

Immune-system strategy used to treat cancer may help with Alzheimer’s — Harvard Gazette

Turning off checkpoint molecules freed microglia to attack plaques in brain, improved memory in mice.

news.harvard.edu

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Reposted by Kuchroo Lab

Seth Thomas Scanlon @immunoeditor.bsky.social · Apr 29

@dixon-lab.bsky.social, Gonzalo Fernandez Lahore, & @kuchroolab.bsky.social discuss the emerging roles for #TIM3 in regulating #MyeloidCell #immune responses!

Beyond T cell exhaustion: TIM-3 regulation of myeloid cells

We provide a comprehensive review of 20 years of research on TIM-3 functions in myeloid cells and T cell exhaustion.

www.science.org

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