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Denis Wirtz

@deniswirtz.bsky.social

5.8K followers 2K following 510 posts

VP for Research, T.H. Smoot Professor Depts Chemical and Biomolecular Engn, Pathology, Oncology, INBT Johns Hopkins University 3D multi-omic, CAR T therapy, cell migration and mechanics Lab: https://wirtzlab.johnshopkins.edu

wirtzlab.johnshopkins.edu

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Denis Wirtz @deniswirtz.bsky.social · 3d

CAR T therapy has seen great effectiveness in liquid tumors, but little in solid tumors (e.g. ovarian cancer).

Here we developed hyper-migratory CAR TV cells to infiltrate en masse ovarian tumors. (Left: control CAR T cells; right CAR TV cells).

Read this here: www.biorxiv.org/content/10.1...

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Denis Wirtz @deniswirtz.bsky.social · 2h

Beautiful.

Denis Wirtz @deniswirtz.bsky.social · 3d

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Denis Wirtz @deniswirtz.bsky.social · 3d

Thanks Dan. This is an error, it should be 256. We used 256 in our paper.

Denis Wirtz @deniswirtz.bsky.social · 4d

Johns Hopkins sophomore student Florin Selaru develops a new scheme to deconvolve colors in histological sections for digital pathology.

It greatly outperforms traditional linear color deconvolution.

Congrats Florin!

Read his paper here: www.biorxiv.org/content/10.1...

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Denis Wirtz @deniswirtz.bsky.social · 5d

Im attending my Institute’s retreat (INBT) at the Bloomberg Center in DC.

Views from the center are the best in DC; in the background is the National Art Gallery (including the iconic building designed by I.M. Pei).

Denis Wirtz @deniswirtz.bsky.social · 6d

We have developed a new workflow to map whole human organs in 3D & at single-cell resolution

Colleague Prof. Luciane Kagohara mapped out the transcriptomic profile + aneuploidy of ovarian precancerous lesions (STIC) in healthy fallopian tube.

More here: www.biorxiv.org/content/10.1...

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Denis Wirtz @deniswirtz.bsky.social · 7d

We have developed a new workflow to map in 3D at single-cell resolution whole human organs.

Prof. Rong Fan (Yale) mapped out immune cell populations in the vicinity of ovarian precancerous lesions in healthy women and found no enrichment.

More here: www.biorxiv.org/content/10.1...

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Denis Wirtz @deniswirtz.bsky.social · 7d

Have a good day!

Denis Wirtz @deniswirtz.bsky.social · 8d

We have developed hyper-migratory CAR T cells that alleviate ovarian cancer metastatic burden and improve prognosis.

We transduce synthetic modular "velocity" receptors that promote fast and deep infiltration of CAR T cells into mets in the liver.

More here: www.biorxiv.org/content/10.1...

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Reposted by Denis Wirtz

Rita Strack @ritastrack.bsky.social · 8d

Please start following @natbiomedeng.nature.com! It's an alive account now and we will start posting good content!

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Denis Wirtz @deniswirtz.bsky.social · 8d

Congratulations Prof. Hotez

Denis Wirtz @deniswirtz.bsky.social · 9d

Fantastic thread on metastasis and causes of cancer-related deaths.

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · 10d

Are 90% of cancer-related deaths due to metastasis? Apparently the overuse of this percentage in reviews has created confusion and questioning of whether this is true. The answer, which is as always cancer type dependent, may be in these references that also people claim they cannot find.

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Reposted by Denis Wirtz

Hao Yin @haoyin.bsky.social · 10d

Comparing single-cell #SpatialTranscriptomics methods on FFPE human tumor #TissueMicroArray

CosMx 1k vs MERFISH 500 vs Xenium-UM/-MM 339
93 common genes

lung adenocarcinoma
pleural mesothelioma

Corr. Bulk RNAseq, GeoMx

#NatureComms 2025
www.nature.com/articles/s41...

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Denis Wirtz @deniswirtz.bsky.social · 10d

Multimodal SRS imaging reveals metabolic remodeling in ovarian precancerous lesions.

In collaboration with Prof. Lingyan Shi (UCSD), we integrated spatial metabolomics into a new 3D tissue mapping workflow at single-cell resolution

More here: www.biorxiv.org/content/10.1...

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Reposted by Denis Wirtz

Oded Rechavi @odedrechavi.bsky.social · 12d

It's probably the deterioration of social media (I hope) but i'm exposed to a lot less cool science. It used to feel like a new cool study is being preprinted/published every week, and lately it's rare (at least so it seems). Share a recent study that's worth knowing!

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Denis Wirtz @deniswirtz.bsky.social · 13d

Merci!

Denis Wirtz @deniswirtz.bsky.social · 13d

Check this out: This is what the human fallopian tube looks like as one travels through its different sections.

We have developed a new 3D single-cell tissue mapping workflow to automatically/accurately detect ovarian cancer precancerous lesions (STICs).

More here: www.biorxiv.org/content/10.1...

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Denis Wirtz @deniswirtz.bsky.social · 15d

Our new workflow maps whole human fallopian tubes at single-cell resolution. In healthy FTs, we detected (many) STIC precancerous lesions.

We can also simulate virtual sectioning as done in the clinic and show how current protocols undersample FTs.

More here:
www.biorxiv.org/content/10.1...

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Denis Wirtz @deniswirtz.bsky.social · 15d

That's next paper.

Denis Wirtz @deniswirtz.bsky.social · 15d

New York, New York!

Denis Wirtz @deniswirtz.bsky.social · 15d

Using a new workflow, we map ciliated (green) and secretory cells (pink) that line the epithelium of whole human fallopian tube.

With age (menopause), the number of ciliated cells decreases and the number of secretory cells increases.

More here: www.biorxiv.org/content/10.1...