Lightnews — Scholar-powered news

Hao Yin @haoyin.bsky.social · 3h

#ApoA #Atherosclerosis

Apolipoprotein A-I Binding Protein deficiency augments #FoamCell formation & TLR4 dimerization on lipid raft/Inflammaraft in hyperlipidemic Ldlr-/-🐭

BODIPY-hi vs -lo lesional macrophage⬅️how much are #SmoothMuscleCell -derived?🧐

bioRxiv 2025
www.biorxiv.org/content/10.1...

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Reposted by Hao Yin

Campàs Lab @campaslab.bsky.social · 7h

Super fun collaboration with @ebisuyamiki.bsky.social
lab to understand the mechanical differences between human, gorilla and mouse forebrain development 🧠 It turns out humans are different! Thanks Miki for making me part of this awesome project! 😀

Miki Ebisuya @ebisuyamiki.bsky.social · 9h

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...

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Reposted by Hao Yin

Micha Sam Brickman Raredon @msbr89.bsky.social · 9h

🔥Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution

www.cell.com/cell/fulltex...

Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution

RAEFISH delivers whole-transcriptome (>20,000 genes) imaging at single-molecule resolution in cells and tissues and enables direct gRNA detection for high-content, image-based CRISPR screens.

www.cell.com

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Reposted by Hao Yin

Developmental Biology @devbiol.bsky.social · 9h

#DBfeature 🪶

New tools bring embryonic feather bud development back to the forefront of efforts to understand vertebrate organogenesis

By Jon Riddell and Denis Headon

tinyurl.com/hzzhr5z8
#SpecialIssue on #Development and #Regeneration of ectodermal organs

(A) Schematic of embryonic chick skin, composed of an epithelial layer overlying a mesenchyme containing cells migrating within an extracellular matrix. During early stages of feather development dermal fibroblasts aggregate underneath epithelial thickenings, known as placodes, to form dermal condensates. (B) Skin explant dissected from an embryonic day 9 (E9) tdTomato transgenic embryo showing feather buds growing out and oriented towards the posterior. Scale bar 1 mm. (C) Dermal condensates form in sequential rows, originating from a dense mesenchymal stripe along the midline of the embryo. This stripe then separates into condensates, with subsequent rows emerging laterally in sequence. (D) In situ hybridisation detecting CTNNB1 expression in E8 chick skin. The red outline highlights the hexagonal arrangement of the 6 nearest-neighbour feather buds. (E) Haematoxylin and eosin stain of an E6.5 chick embryo section. The red dashed rectangle highlights the loose dermis, the green dashed rectangle highlights the dense dermis. Left panel scale bar = 200 μm, right panel scale bars = 100 μm.

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Reposted by Hao Yin

preLights @prelights.bsky.social · 9h

Hsp70 phosphorylation stalls cell cycle, buying time for DNA repair

Ana Sanchez-Molina: “This #preprint provides detailed mechanistic, biochemical, and genetic evidence of a conserved mechanism of cell cycle regulation in response to DNA damage.” #preLight ⬇️
prelights.biologists.com/highlights/a...

A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage - preLights

Hsp70 phosphorylation stalls cell cycle, buying time for DNA repair.

prelights.biologists.com

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Hao Yin @haoyin.bsky.social · 10h

p21/Rb-activated SMAD/STAT/NFκB-dependent secretome activates a reversible immunoclearance program

Fibroblast in vitro
Hepatocyte in vivo

Senescence-independent😎

CXCL14
IGFBP3
ADAM15
SSC5D
APP
FN1
Prosaposin

@science.org 2021
www.science.org/doi/10.1126/...

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Reposted by Hao Yin

Theory of Living Matter Group @tlmcambridge.bsky.social · 10h

🚨 TLM Online Seminar Series - TODAY 16:00 UK
Pablo Sáez: "Decision-making during cell migration"

Please repost & to attend online please register to our 📧for the zoom link: lists.cam.ac.uk/sympa/subscr...

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Reposted by Hao Yin

Christophe 🔬 L @christlet.bsky.social · 1d

See you there! Will try to throw a cytoskeleton party for my birthday 🎇

EMBO @embo.org · 1d

Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪

Structure and Function of the Cytoskeleton

The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …

meetings.embo.org

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Reposted by Hao Yin

Colin Campbell @raleighreporter.bsky.social · 21h

Come join our team covering #ncpol/#ncga for public radio stations across NC!

WUNC News @wunc.org · 1d

WUNC is currently hiring a reporter for the NC Newsroom. Interested in applying? Learn more at the link below!

www.wunc.org/wunc-jobs

WUNC Jobs

Work with us at North Carolina Public Radio - WUNC! Join us in our mission to provide high-quality news, cultural and entertainment content to create a more informed and engaged community in the the R...

www.wunc.org

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Reposted by Hao Yin

Developmental Biology @devbiol.bsky.social · 1d

#DBfeature 🐠🫀

Gpnmb promotes the recruitment of macrophages post cardiac cryoinjury in zebrafish, influencing immune and fibrotic responses during regeneration

-S Gupta, GK Bajwa, H El-Sammak, K Mattonet, S Günther, M Looso, D Stainier, R Marín-Juez @rmarinjuez.bsky.social

tinyurl.com/yc7hv5dn

Upper panel: Immunostaining of zebrafish ventricles at 7 dpci after cryoinjury shows fewer macrophages (mpeg1:EGFP⁺, magenta) in gpnmb⁻/⁻ ventricles compared with wild-type. DAPI staining (blue) marks nuclei (B). Quantification confirms a significant reduction in macrophage numbers within the injured border zone of gpnmb⁻/⁻ tissue (C).

Lower panel: Acid Fuchsin Orange-G (AFOG) stained sections of zebrafish cryoinjured ventricles show that gpnmb⁻/⁻ ventricles develop larger collagen-rich scars than wild-type at 30 and 90 dpci (F and G). Quantification illustrates greater proportions of large scar areas in gpnmb⁻/⁻ ventricles (H), indicating impaired scar resolution and delayed cardiac regeneration.

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Hao Yin @haoyin.bsky.social · 1d

#TissueEngineeredVascularGraft

#hiPSC #SmoothMuscleCell on 3-mm PGA tubular scaffold

Decellularized

Rupture pres 1200 mmHg
Suture retent str 120 g

Re-endothelialized⏩rat aortic graft 30 d
❎thrombus
Repop by host EC

#CircRes 2022 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...

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Reposted by Hao Yin

David Gaboriau @dgaboriau.bsky.social · 1d

Top position in Paris with Jean-Yves @jytinevez.bsky.social

#bioimageanalysis 🔬

Jean-Yves Tinevez @jytinevez.bsky.social · 1d

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

forum.image.sc

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Reposted by Hao Yin

Joachim Goedhart @joachimgoedhart.bsky.social · 12d

Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM by Juan Manuel Garcia-Arcos and team: www.biorxiv.org/content/10.1...

Frequency dependence of fast-lifetime FLIM and fits for C2C12 cells.

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Reposted by Hao Yin

Thibaut Brunet @thibautbrunet.bsky.social · 3d

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

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Reposted by Hao Yin

Jean-Yves Tinevez @jytinevez.bsky.social · 1d

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

forum.image.sc

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Reposted by Hao Yin

Claire Dessalles @clairedessalles.bsky.social · 1d

All you've ever wanted to know about FLIM analysis (and its application in Flipper-TR)!😱🤩🔬

Juanma García-Arcos @juanmagararc.bsky.social · 3d

🚨 New preprint out!
“Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social
We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies.

www.biorxiv.org/content/10.1...

Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM

Flipper-TR is a membrane dye sensitive to lipid packing widely used to probe membrane tension in live cells via fluorescence lifetime imaging microscopy (FLIM). However, no consensus currently exists ...

www.biorxiv.org

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Reposted by Hao Yin

Manuel Thery @manuelthery.bsky.social · 1d

What would happen if cells would express more molecular motors ?
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social

rupress.org/jcb/article-...

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Reposted by Hao Yin

Daniel Drucker @danieljdrucker.bsky.social · 1d

Sweetening the diet with artificial sweeteners reveals in a clinical trial that prolonged consumption of S&SEs in a healthy diet is a safe strategy for #obesity management #weightloss #microbiota www.nature.com/articles/s42...

Effect of sweeteners and sweetness enhancers on weight management and gut microbiota composition in individuals with overweight or obesity: the SWEET study - Nature Metabolism

The SWEET project is a multicenter, randomized, controlled trial that shows that long-term consumption of sweeteners and sweetness enhancers improves body weight control and elicits beneficial gut microbiota changes in adults with overweight or obesity.

www.nature.com

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Reposted by Hao Yin

Konstantinos Miti @mitisbio.bsky.social · 1d

Our calcium paper is out in PLOS Biology!
Check it out! #Calcium #Embryo #Development

PLOS Biology @plosbiology.org · 1d

During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4

Epiblast Ca2+ waves propagate from the apical to basal domain. The images show selected time points from movies of E5.5 GCaMP6f embryos imaged using a ZEISS lattice light-sheet 7 microscope. Top row: An example of an epiblast wave involving a large proportion of the tissue captured by imaging a volume of the embryo at 20-s intervals. A total of 9/16 embryos showed at least one epiblast Ca2+ wave. Bottom row: Faster imaging at 5-s interval revealed that the Ca2+ wave in the epiblast can be preceded by a transient in a neighboring VE cell—this was observed in 5/19 events from 9 embryos (white arrowheads).

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Hao Yin @haoyin.bsky.social · 1d

My continued biomedical education

Pannexins in the vasculature

A comprehensive review from Cryo-EM structure, mechanosensing & ATP-releasing to vascular diseases Atherosclerosis AAA Hypertension Edema Thrombosis

@brantisakson.bsky.social #AJPHeartCirc 2025
journals.physiology.org/doi/abs/10.1...

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Reposted by Hao Yin

myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 1d

Calcium-Regulated Mitochondria Remodeling by Myo19 is Required for Filopodia Tip-Extension

www.biorxiv.org/content/10.1...

Calcium-Regulated Mitochondria Remodeling by Myo19 is Required for Filopodia Tip-Extension

Mitochondria are highly adaptable organelles that change their shape, distribution, and movement to meet cellular needs. We investigate how EGF stimulation remodels mitochondrial behavior in human A43...

www.biorxiv.org

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Reposted by Hao Yin

Reto Fiolka @retof.bsky.social · 2d

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

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Reposted by Hao Yin

Harmit Singh Malik @harmitmalik.bsky.social · 1d

Visiting UT Austin in Integrative Biology and came across this fantastic opportunity for senior grad students in the life sciences.

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Hao Yin @haoyin.bsky.social · 1d

Developmental or Synthetic Biologists or Biological Engineers, don't miss this excellent opportunity at U of T 🇨🇦
I have a program-in-imagination on how mural cells shape organotypic vascular morphogenesis 😆

Mark Peifer (He, him) @peiferlabunc.bsky.social · 2d

Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...

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Reposted by Hao Yin

Mark Peifer (He, him) @peiferlabunc.bsky.social · 2d

Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...

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