@myosinactncrazy.bsky.social
920 followers 79 following 250 posts
#1 molecular motor, cytoskeletal motors, cytoskeletal filaments, filament dynamics, cell migration, mechanobiology, morphogenesis
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 6h
elifesciences.org/reviewed-pre...
Stall force measurement of the kinesin-3 motor KIF1A using a programmable DNA origami nanospring
elifesciences.org
Reposted
biorxiv-cellbio.bsky.social
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 21h
MAP4-MAP7D1 partitioning on tyrosinated-detyrosinated microtubules coordinates lysosome positioning in nutrient signalling https://www.biorxiv.org/content/10.1101/2025.10.07.680844v1
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Reposted
embo.org
EMBO @embo.org · 1d
Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪
Structure and Function of the Cytoskeleton
The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …
meetings.embo.org
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 1d
Calcium-Regulated Mitochondria Remodeling by Myo19 is Required for Filopodia Tip-Extension

www.biorxiv.org/content/10.1...
Calcium-Regulated Mitochondria Remodeling by Myo19 is Required for Filopodia Tip-Extension
Mitochondria are highly adaptable organelles that change their shape, distribution, and movement to meet cellular needs. We investigate how EGF stimulation remodels mitochondrial behavior in human A43...
www.biorxiv.org
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 2d
www.jbc.org/article/S002...
S2Tag, a novel affinity tag for the capture and immobilization of coiled-coil proteins: application to the study of human β-cardiac myosin
Single molecule and ensemble motility assays are powerful tools for investigating myosin activity. A key requirement for the quality and reproducibility of the data obtained with these methods is the ...
www.jbc.org
myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 3d
awesome training opportunity alert!
katrinavelle.bsky.social
Katrina Velle @katrinavelle.bsky.social · 3d
PhD or Master's position available for Fall 2026!

Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 3d
this is a terrific paper showing that Toxo MyoF works as small assemblies of 6 motors that can bind MTs and slide actin filaments. many other interesting observations, highly recommended reading for the myosin aficionados out there.

studying motors in diverse organisms teaches us so much!
Reposted
thibautbrunet.bsky.social
Thibaut Brunet @thibautbrunet.bsky.social · 3d
Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 3d
Thick filament molecular interfaces play a critical role in pathogenesis of hypertrophic and dilated cardiomyopathy

www.biorxiv.org/content/10.1...
Thick filament molecular interfaces play a critical role in pathogenesis of hypertrophic and dilated cardiomyopathy
Hypertrophic (HCM) and dilated (DCM) cardiomyopathy variants in genes encoding the myosin heavy chain (MYH7), myosin light chains (MYL2 and MYL3), and cardiac myosin binding protein-C (cMyBP-C, MYBPC3...
www.biorxiv.org
myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 4d
Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii

www.biorxiv.org/content/10.1...
Molecular features of Myosin F adapted for driving actin flows in Toxoplasma gondii
Toxoplasma gondii ( T. gondii ) is a single-celled Apicomplexan parasite that relies on a highly polarized endomembrane system for its invasion into and survival within host cells. Recent advancements...
www.biorxiv.org
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 5d
Diverse ancestral myosin motors generate and segregate distinct types of nanocluster-rich domains at the plasma membrane

www.biorxiv.org/content/10.1...
Diverse ancestral myosin motors generate and segregate distinct types of nanocluster-rich domains at the plasma membrane
Molecular organization of the plasma membrane (PM) at nano and micron scales is critical for its function in all living cells. This emerges not only from the self-assembly of lipids and proteins but a...
www.biorxiv.org
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 5d
www.biorxiv.org/content/10.1...
A mechanical origin for implantation defects in embryos from aged females
Women over 35 experience a marked reduction in fertility. The origin of these fertility defects appears to reside in the implantation capacity of the embryo itself, but the mechanistic basis of this i...
www.biorxiv.org
myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 6d
www.nature.com/articles/s41...
Dynamic rigidity changes enable rapid cell migration on soft substrates - Nature Communications
Cells struggle to migrate on soft substrates, which don’t provide enough traction. Here, the authors show that rapid, cyclic changes in substrate rigidity allow cells to overcome this limitation and move quickly.
www.nature.com
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 7d
www.nature.com/articles/s41...
Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically - Nature Communications
Hypertrophic cardiomyopathy-causing mutations in cardiac myosin disrupt its auto-inhibited OFF state, leading to hypercontractility. Here, the authors show that disease-linked mutations remote from intramolecular OFF state interfaces can allosterically impair myosin autoinhibition
www.nature.com
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 9d
www.nature.com/articles/s41...
Molecular basis for the activation of outer dynein arms in cilia - Nature Structural & Molecular Biology
Issa et al. show that the ciliary small guanosine triphosphatase Arl3 displaces the inhibitory regulator Shulin/DNAAF9 from the outer dynein arm, leading to motor activation.
www.nature.com
Reposted
nadjahuempf.bsky.social
Nadja M. Hümpfer @nadjahuempf.bsky.social · 10d
Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF
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Reposted
agoren.bsky.social
Alon Goren @agoren.bsky.social · 10d
And from other labs’ work this is really cool:
www.science.org/doi/10.1126/...
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness
Epigenetic control of gene expression and cellular phenotype is influenced by changes in the local microenvironment, yet how mechanical cues precisely influence epigenetic state to regulate transcript...
www.science.org
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 12d
Nonmuscle myosin 2 turnover in cells is synergistically controlled by the tail and the motor domain

www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 14d
www.biorxiv.org/content/10.1...
FAST: Filamentous Actin Segmentation Tool for quantifying cytoskeletal organization
Studying how actin filaments are assembled into different subcellular structures can provide insights into both physiological processes and the mechanisms of disease. However, quantifying the size, ab...
www.biorxiv.org
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 19d
Phase separation strength controls actin filament treadmilling

www.biorxiv.org/content/10.1...
Phase separation strength controls actin filament treadmilling
Cellular motility relies on the dynamic turnover of actin filaments, which treadmill through continuous polymerization at the barbed end and disassembly at the pointed end. Yet, the underlying physica...
www.biorxiv.org
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 19d
Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation

- nice work showing that an F-actin cage-like structure surrounding oocytes polar MTOCs relies on MYO10 and MYO7B.

www.nature.com/articles/s41...
Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation - Nature Communications
Errors in oocyte division can cause infertility and birth defects. Here, authors combine a genetic strategy with a novel optochemical tool to show that spindle pole-localized F-actin is essential for ...
www.nature.com
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Reposted
katrinavelle.bsky.social
Katrina Velle @katrinavelle.bsky.social · 22d
”Please inhibit responsibly: Natural and synthetic actin toxins as useful tools in cell biology”

I had a lot of fun going down different actin inhibitor rabbit holes with @onishilab.bsky.social on this perspective!

www.molbiolcell.org/doi/10.1091/...

www.molbiolcell.org/cms/10.1091/...
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Reposted
drmichaelway.bsky.social
Michael Way @drmichaelway.bsky.social · 22d
And now for something completely different @tianyang22.bsky.social & #YanCao uncover of how SPIN90 dimers activate Arp2/3 to nucleate bidirectional linear actin filaments. Great collaboration with @romet-jegou-lab.bsky.social & @carolynmoores1.bsky.social #Cryo-EM #Arp2/3 rdcu.be/eGoH4
Arp2/3-mediated bidirectional actin assembly by SPIN90 dimers
Nature Structural & Molecular Biology - Liu et al. show that SPIN90 dimerizes and binds two Arp2/3 complexes to nucleate two bidirectional actin filaments and the dimerization domain is...
rdcu.be
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 23d
The G256E HCM mutation prolongs relaxation via altered nucleotide handling

www.biorxiv.org/content/10.1...
www.biorxiv.org
Reposted
samstehbens.bsky.social
A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 25d
Exciting new work from the #Schaedel lab on the limits of microtubule self repair > will help us understand how #microtubules experiencing extreme compression in crowded 3D environments resist or give way.
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