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Reposted by Thibaut Brunet

Alex de Mendoza @alexdemendoza.bsky.social · 3h

Thrilled to share that the lab has been awarded a @wellcometrust.bsky.social Discovery Award to keep exploring the evolution of 6-methyladenine #6mA in Eukaryotes. We'll open postdoc (3️⃣) and tech (1️⃣) positions to start in 2026, please share with candidates or reach out if you’d like to join us.

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Reposted by Thibaut Brunet

Sally Warring @sallywarring.bsky.social · 2d

A new preprint from us using a single-cell genome pipeline to investigate diversity of uncultured Bodo spp. flagellates.

We isolated 7 Bodo spp. cells from a single environmental sample and show that they represent 3 Bodo sp. each with a unique species of bacterial endosymbiont. #protistsonsky

Single-cell sequencing reveals unexpected genetic diversity among Bodo spp. flagellates and their bacterial endosymbionts

Bodo is a cosmopolitan genus of free living bacterivorous single-celled flagellates in the class Kinetoplastea. Members of genus Bodo are considered the closest free-living relatives to the parasitic ...

www.biorxiv.org

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Reposted by Thibaut Brunet

Institut Pasteur | 130 years of biomedical research @pasteur.fr · 7h

Pour chaque vie, la science agit.
Le Pasteurdon, c’est maintenant !
Soutenez la recherche et celles et ceux qui la font avancer ↘️ pasteurdon.fr
#Pasteurdon

Pour chaque vie, la science agit. Le Pasteurdon, c’est maintenant ! Soutenez la recherche et celles et ceux qui la font avancer. Faites un don sur pasteurdon.fr

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Thibaut Brunet @thibautbrunet.bsky.social · 18h

Join us!

EMBO @embo.org · 1d

Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪

Structure and Function of the Cytoskeleton

The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …

meetings.embo.org

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Reposted by Thibaut Brunet

EMBO @embo.org · 1d

Learn all things #cytoskeleton #research in an interdisciplinary environment at EMBO Workshop "Structure and Function of the Cytoskeleton" in Paris, FR, 7–10 April 2026.

Deadline: 20 December 2025

https://meetings.embo.org/event/26-cytoskeleton
#EMBOCytoskeletalFunction #EMBOevents #conference 🧪

Structure and Function of the Cytoskeleton

The cytoskeleton, a dynamic and intricate network of protein filaments, is found within the cytoplasm of all cells, from bacteria and archaea to complex eukaryotes. This essential cellular component …

meetings.embo.org

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Thibaut Brunet @thibautbrunet.bsky.social · 1d

Great opportunity to do bioimage analysis in an exceptional environment!

Jean-Yves Tinevez @jytinevez.bsky.social · 1d

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

forum.image.sc

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Thibaut Brunet @thibautbrunet.bsky.social · 1d

Thanks Adrien! actually we haven't yet tested mechanosensing in this paper (but stay tuned).

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Reposted by Thibaut Brunet

Ben Engel @cellarchlab.com · 8d

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

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Reposted by Thibaut Brunet

Thomas Lecuit @thomaslecuit.bsky.social · 1d

Pleasure to announce the program of my new series of lectures at the College de France in Nov-Dec. Continuing on the theme of Biological information. I will focus on the computational aspects, building on David Marr's tri-level of analysis in biological systems. YouTube link sent when it starts.

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Thibaut Brunet @thibautbrunet.bsky.social · 2d

Thanks Max!

Reposted by Thibaut Brunet

Gaspar Jekely @jekely.biologists.social.ap.brid.gy · 2d

Postdoc position in regenerative biology on "Tracking the cellular origins regeneration" in the @michalis_averof lab in Lyon, France. Fantastic lab, great institute, nice city!
https://www.averof-lab.org/pages/tracman

#postdoc

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Reposted by Thibaut Brunet

Katrina Velle @katrinavelle.bsky.social · 2d

PhD or Master's position available for Fall 2026!

Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!

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Reposted by Thibaut Brunet

James Gahan @jgahan.bsky.social · 3d

Amazing work by @thibautbrunet.bsky.social and his lab! I can’t stress enough how significant a development this is for Choanoflagellate research and it has been revolutionary for our work!

Thibaut Brunet @thibautbrunet.bsky.social · 3d

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Thanks James - the pipeline has been transformative for us too. I must say thank god for biorXiv, through which we could share it early and proceed with long revision experiments (from which came most insights on Hippo) without feeling like we were withholding a protocol from the community...

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

oops, one day I'll manage to remember this hashtag

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Thanks Prof. Dudin! 🙏

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Thanks for sticking until the end, and for more insights (notably on different knock-out techniques and on the risk posed by unexpected alternative start codons...), check out the paper: www.cell.com/cell-reports... 🙏

A selection-based knockout approach for a choanoflagellate reveals regulation of multicellular development by Hippo signaling

Combredet et al. report a robust and fast gene-knockout method for the choanoflagellate Salpingoeca rosetta, one of the closest relatives of animals. Inactivation of genes encoding homologs of compone...

www.cell.com

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Together, this suggests that Hippo/YAP might have already controlled both contractility and ECM secretion before animals evolved. Animals plugged in one additional output: proliferation. Under this hypothesis, the best-known function of YAP would have been the latest innovation.

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Conservation might extend even further: DJ Pan's lab had shown that YAP helps multicellular colonies resist flattening by gravity in yet another relative of animals (the filopodiated amoeba Capsaspora) by making cells more contractile -a function also present in zebrafish tinyurl.com/323jmdht

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

To me (but I'm biased), this is intriguingly similar to the self-terminating, ECM-driven multicellular development of S. rosetta. This suggests either ancestral use, or independent co-option, of similar signaling and cellular modules for multicellular development in choanos and animals.

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

And just a few weeks ago, beautiful work by @akankshi.bsky.social has shown that a self-terminating YAP/ECM loop sets organ size in zebrafish semicircular canals: www.biorxiv.org/content/10.1...

A self-limiting mechanotransduction feedback loop ensures robust organ formation

Organ development requires integration of mechanical forces, biochemical signals, and transcriptional programs to achieve proper size and architecture. Mechanotransduction feedback loops convert mecha...

www.biorxiv.org

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Is this YAP/ECM connection a choano oddity? Not necessarily: recently, links between Hippo/YAP and ECM have been emerging in animals. One of the most commonly reported YAP targets is cyr61, a thrombospondin-domain protein that's part of the ECM... www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

This nicely tied in with the earlier genetic and biophysical evidence that ECM quantity sets choano rosette size and shape. Targets of Warts/Yorkie included collagen, laminin-like proteins, C-type lectins - and couscous, one of the "rosette development genes" from the historical mutant screen.

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

... but there's a catch: in animals, YAP most canonically acts by controlling cell proliferation. In S. rosetta, we found no evidence that the Warts phenotype would be due to increased cell division. Instead, RNAseq revealed massive upregulation of ECM components in giant rosettes.

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Surprisingly, disrupting warts kinases in S. rosetta caused a very animal-like phenotype: giant rosettes colonies!

This suggests the molecular pathways that control multicellular development in animals and choanos might be more conserved than we expected...

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