Lightnews — Scholar-powered news

Ben Engel @cellarchlab.com · 1d

Hellooooo beautiful!😍 #CryoEM #ArchaeaSky 🧪

The Daum Lab @daumlab.bsky.social · 2d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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Ben Engel @cellarchlab.com · 2d

#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪

Jakob Meier-Credo @meiercredo.bsky.social · 18d

Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

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Ben Engel @cellarchlab.com · 2d

This is rad! It gets me excited for the potential with mixed environmental samples. Congrats to you, @andschwarz.bsky.social and the crew!

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Ben Engel @cellarchlab.com · 4d

Delightful to finally meet you @edwardmarcotte.bsky.social and hear about your crazy cool science exploring the proteomes of all the diverse beasties on the planet to reconstruct LECA 🧪🌎. Now I see where Caitie gets it from 👨‍🔬👩‍🔬

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Reposted by Ben Engel

Caitie McCafferty @computingcaitie.bsky.social · 4d

So much fun to host @edwardmarcotte.bsky.social at the @biozentrum.unibas.ch and introduce him to the @cellarchlab.com, thanks for a wonderful Discovery Seminar!!

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Ben Engel @cellarchlab.com · 7d

Can they make eggs from male skin cells? Or sperm from female skin cells? Now that would be interesting….

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Reposted by Ben Engel

Alicia Michael @aliciakmichael.bsky.social · 7d

A place with fantastic colleagues, excellent facilities, a stimulating scientific environment, and a very international and vibrant city - it's got it all!

Ben Engel @cellarchlab.com · 8d

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

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Reposted by Ben Engel

Karolin Luger @nucleosomepolice.bsky.social · 7d

Biocenter is THE BEST!

Biozentrum, University of Basel @biozentrum.unibas.ch · 9d

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

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Reposted by Ben Engel

David Brückner @davidbrueckner.bsky.social · 8d

Come join us in Basel! @biozentrum.unibas.ch is an amazing place to start your group.

Biozentrum, University of Basel @biozentrum.unibas.ch · 9d

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

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Ben Engel @cellarchlab.com · 8d

Yay @centriolelab.bsky.social !! 🙌

Ali Shaib @alishaib.bsky.social · 8d

#GEF25 Concluding Plenary Lecture with the wonderful Virginie Hamel.

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Ben Engel @cellarchlab.com · 8d

I think it has something to do with conservative lawmakers taking aim at liberal-leaning social media. See this announcement that my friend got. Did you get something similar? X is not affected by this law, and that place is swarming with misinformation and porn bots. No free speech = Hot Garbage 🔥🗑️

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Ben Engel @cellarchlab.com · 8d

What's it like to live in Basel and do basic science 🧪 at the @biozentrum.unibas.ch?

Take a look 👀👇
www.biozentrum.unibas.ch/about/biozen...

International Researchers - Biozentrum

www.biozentrum.unibas.ch

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Ben Engel @cellarchlab.com · 8d

EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓

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Ben Engel @cellarchlab.com · 8d

The former supervisor of @computingcaitie.bsky.social is coming to visit and tell us all about structural proteomics. Looking forward to this #DiscoverySeminar from @edwardmarcotte.bsky.social !! 😃

#ProteinCosmos 🧶🧬

Biozentrum, University of Basel @biozentrum.unibas.ch · 12d

On Friday, October 3, we will welcome our next #DiscoverySeminar speaker, Prof. @edwardmarcotte.bsky.social @utaustin.bsky.social. Join his lecture on "Modern Cells, Ancient Proteins: Proteomics Across Deep Evolutionary Time to Decode Human Genetics" @biozentrum.unibas.ch @unibas.ch

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Ben Engel @cellarchlab.com · 9d

Thanks for highlighting our work! Here's a thread 🧵 diving into our findings and how they fit into those long-standing debates. #TeamTomo #PlantScience 🧪 🌾 🔬

bsky.app/profile/cell...

Ben Engel @cellarchlab.com · 12d

Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!

#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
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Reposted by Ben Engel

Ricardo D. Righetto @lifeonthewedge.bsky.social · 10d

The case for studying proteins inside the cell 😉

#CryoET #TeamTomo

Ben Engel @cellarchlab.com · 12d

But there’s a curious loose end to this story. Scientists have been looking at PSII organization in thylakoids for over 50 years (including some really stunning freeze fracture 🔬😍). Sometimes PSII looks randomly oriented, and other times it forms extended 2D crystalline arrays in the membrane 💠

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Reposted by Ben Engel

Ben Engel @cellarchlab.com · 10d

Love it! 🧪🤓 Ya know, thylakoids can also play this paracrystalline lattice game. In plants, they emerge from the prolamellar body during de-etiolation 🟡➡️🟢

Little piece by @wojwie.bsky.social & me:
www.nature.com/articles/s41...

Lovely review by Andrew Staehelin💚:
link.springer.com/article/10.1...

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Ben Engel @cellarchlab.com · 10d

Love it! 🧪🤓 Ya know, thylakoids can also play this paracrystalline lattice game. In plants, they emerge from the prolamellar body during de-etiolation 🟡➡️🟢

Little piece by @wojwie.bsky.social & me:
www.nature.com/articles/s41...

Lovely review by Andrew Staehelin💚:
link.springer.com/article/10.1...

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Ben Engel @cellarchlab.com · 10d

An interesting parallel: Rod outer-segment disk membranes are highly packed with a membrane protein (rhodopsin) 👁️, similar to the stacked domains of thylakoids (PSII-LHCII) 🌱. And isolation of disk membranes may cause rhodopsin to crystallize into 2D arrays 💠

www.nature.com/articles/421... 🧪 🧶🧬🌾🔬

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Ben Engel @cellarchlab.com · 12d

Thanks Marcel! But don’t you mean the prettiest membranes on Earth? 😉. Golgi tried hard…. but thylakoids are the best 🌱🏆

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Ben Engel @cellarchlab.com · 12d

Thanks Harry! Now back to work on the figure🎨 for our collab paper. Almost done… ⏰😅

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Ben Engel @cellarchlab.com · 12d

Here's a thread🧵 diving into some of the observations of this #TeamTomo #PlantScience study 🧪 🌾

bsky.app/profile/cell...

Ben Engel @cellarchlab.com · 12d

Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!

#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
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Ben Engel @cellarchlab.com · 12d

Last but not least, HUGE thanks🙏 to all our collaborators (especially the very patient @profmattjohnson.bsky.social) & everyone who helped along the (long long) way!🤗

#TeamTomo @drlornamalone.bsky.social @dtegunov.bsky.social
@mpibiochem.bsky.social @pioneercampus.bsky.social @biozentrum.unibas.ch

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Ben Engel @cellarchlab.com · 12d

This study completes a trilogy of thylakoid papers in @elife.bsky.social, one every 5 years⏳⌛

Part 1 was my first #CryoET paper: elifesciences.org/articles/04889

Part 2 was my first paper with @wojwie.bsky.social: elifesciences.org/articles/53740

Time flies... so let's start working on Part 4? 🤓🧪

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Ben Engel @cellarchlab.com · 12d

So, PSII arrays seem to be an artifact of isolating thylakoid membranes. And yet… We still wonder if these beautiful (and likely more static) structures play some physiological role during stress or damage. @wojwie.bsky.social & I wrote a mini-review on this:

academic.oup.com/plcell/artic...

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