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Reposted by Ricardo D. Righetto

The Daum Lab @daumlab.bsky.social · 2d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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Reposted by Ricardo D. Righetto

Merissa Huei-Hsuan Tsai @hueihsuantsai.bsky.social · 5d

Very excited to see our @nikogeldner.bsky.social lab x Feng Zhou lab work featured on the cover of Science!
(1/5) We reveal how root architecture and nutrient leakage shape spatial patterns of microbial colonization, moving beyond traditional models of uniform exudation.

Science Magazine @science.org · 6d

Using precise spatial and temporal analysis, researchers in Science provide insight into how bacteria around the root interact both with the plant and with each other.

Learn more in this week's issue: https://scim.ag/3WgNajk

A confocal microscopy image shows root-colonizing bacteria clustering around an emerging lateral root, where localized glutamine leakage induces spatially confined reporter activity.

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 11d

The case for studying proteins inside the cell 😉

#CryoET #TeamTomo

Ben Engel @cellarchlab.com · 13d

But there’s a curious loose end to this story. Scientists have been looking at PSII organization in thylakoids for over 50 years (including some really stunning freeze fracture 🔬😍). Sometimes PSII looks randomly oriented, and other times it forms extended 2D crystalline arrays in the membrane 💠

9/🧵

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Reposted by Ricardo D. Righetto

Ben Engel @cellarchlab.com · 13d

Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!

#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
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Ricardo D. Righetto @lifeonthewedge.bsky.social · 13d

Yes, cyano 🦠
Could be!?!?

Reposted by Ricardo D. Righetto

Ricardo D. Righetto @lifeonthewedge.bsky.social · 13d

real carboxysome with ribos, thylakoids and a mysterious triangle to scale 😉

(from @sofie-dot-rec.bsky.social)

Slice of a cryo-ET volume showing a carboxysome, thylakoid membranes, ribosomes and a mysterious triangular structure.

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 13d

real carboxysome with ribos, thylakoids and a mysterious triangle to scale 😉

(from @sofie-dot-rec.bsky.social)

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 13d

The CAGE is out of the... cage?

Caitie McCafferty @computingcaitie.bsky.social · 15d

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 16d

I find it... compelling 😉

eLife @elife.bsky.social · 18d

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 19d

Life saver!

Ricardo D. Righetto @lifeonthewedge.bsky.social · 19d

and yes I had to look up the alphabet on wikipedia 🫣

Ricardo D. Righetto @lifeonthewedge.bsky.social · 19d

I never expected to write this line of code

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 19d

especially not at this hour

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 19d

I never expected to write this line of code

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 22d

Amazing work, Oli & team!

1. Have you tried perturbing the orientations (by different amounts) and seeing if the local refinement still converges?

2. Do you impose a hard resolution cutoff in refinement, and if not, wouldn't it make your FSC more reliable?

Congrats!

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 22d

A protocol to solve ~30 kDA proteins by #cryoEM 🤩 - I love it!

Oli Clarke @olibclarke.bsky.social · 25d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

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Reposted by Ricardo D. Righetto

Arjen Jakobi @cryotud.bsky.social · 23d

We finally wrote up the paper for LocScale-2.0.

edu.nl/pvhxv

Please try it out. LocScale is evolving & we are actively building in new features and improvements. Your feedback will help us shape the next steps.

Code: cryotud.github.io/locscale/

Work by @alok-bharadwaj.bsky.social and Reinier.

Arjen Jakobi @cryotud.bsky.social · May 22

We are happy to release LocScale2.0: a tool for context-aware, confidence-weighted cryoEM map optimisation.

Taking two half maps as input, LcoScale-2.0 produces feature-enhanced maps along with a robust confidence score that guides objective map interpretation.

cryotud.github.io/locscale/

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 25d

A masterpiece

Filipe Campante @filipecampante.bsky.social · 26d

My opinion about the historic verdict coming out of Brazil, with @stevelevitsky.bsky.social, is in the @nytimes.com today.

www.nytimes.com/2025/09/12/o...

Opinion | Brazil Just Succeeded Where the U.S. Failed

www.nytimes.com

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Reposted by Ricardo D. Righetto

Derek Lowe @dereklowe.bsky.social · 27d

Life on Mars? The latest results and what to do about them:

Life, Maybe, On Mars, Unless We Change Our Minds

www.science.org

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Reposted by Ricardo D. Righetto

Thiago Carvalho @cyrilpedia.bsky.social · 26d

“The higher you go, the smaller the proportion of women relative to men,” she said in a 1970 Royal Institution discourse for which the recording has just been released. “This applies to all subjects, but especially to science.”

www.ft.com/content/96d5...

The crystallographer who solved a molecular mystery

A lecture by the pioneering scientist Kathleen Lonsdale has been chosen to celebrate the 200th anniversary of the Royal Institution’s discourses

www.ft.com

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Reposted by Ricardo D. Righetto

Fernando @punkbiology.bsky.social · 26d

Militares sendo condenados por tentativa de golpe num país da América Latina.

Não é pouca coisa.

E no dia em que lembramos do golpe militar patrocinado pelos EUA no Chile. Simbólico.

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Reposted by Ricardo D. Righetto

The New York Times @nytimes.com · 26d

Breaking News: Brazil’s Supreme Court convicted former President Jair Bolsonaro of plotting a coup after losing the 2022 election. He could face decades in prison. nyti.ms/4pyzL3Q

Jair Bolsonaro, wearing a yellow and green shirt, is speaking into a microphone. A headline reads: "Jair Bolsonaro Convicted of Attempting a Coup in Brazil." Photo by Dado Galdieri for The New York Times

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 26d

🍺

A s t o r @astordasilva.bsky.social · 27d

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Reposted by Ricardo D. Righetto

Simon Dürr @handle.invalid · 27d

La-Proteina from NVidia to do co-design of fully atomistic protein structures (sequence + side-chains + backbone) for up to 800 residues is now open source with permissive licensing

🖥️ github.com/NVIDIA-Digit...
🗎 arxiv.org/abs/2507.09466

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 28d

Relacionado: www.nytimes.com/2023/08/28/b...

How Ozempic and Weight Loss Drugs Are Reshaping Denmark’s Economy (Published 2023)

www.nytimes.com

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 28d

Enquanto isso, eles fecham centros de pesquisa básica 🤷🏽‍♂️

www.embopress.org/doi/full/10....

The mission to ensure continued funding for excellent basic research | EMBO reports

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

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