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Reposted by Caitie McCafferty

Thibaut Brunet @thibautbrunet.bsky.social · 3d

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

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Caitie McCafferty @computingcaitie.bsky.social · 4d

So much fun to host @edwardmarcotte.bsky.social at the @biozentrum.unibas.ch and introduce him to the @cellarchlab.com, thanks for a wonderful Discovery Seminar!!

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Reposted by Caitie McCafferty

Biozentrum, University of Basel @biozentrum.unibas.ch · 9d

Assistant/Associate Professor in Structural Biology, Biophysics or Biological Imaging

www.biozentrum.unibas.ch/open-positio...

#biozentrum #University #Basel #Professor #Structural #Biology #Biophysics #Biological #Imaging

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Caitie McCafferty @computingcaitie.bsky.social · 8d

You don’t want to miss this one!

Ben Engel @cellarchlab.com · 8d

The former supervisor of @computingcaitie.bsky.social is coming to visit and tell us all about structural proteomics. Looking forward to this #DiscoverySeminar from @edwardmarcotte.bsky.social !! 😃

#ProteinCosmos 🧶🧬

Biozentrum, University of Basel @biozentrum.unibas.ch · 12d

On Friday, October 3, we will welcome our next #DiscoverySeminar speaker, Prof. @edwardmarcotte.bsky.social @utaustin.bsky.social. Join his lecture on "Modern Cells, Ancient Proteins: Proteomics Across Deep Evolutionary Time to Decode Human Genetics" @biozentrum.unibas.ch @unibas.ch

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Reposted by Caitie McCafferty

Ben Engel @cellarchlab.com · 14d

Meet the CAGE: a newly-discovered protein nanocapsule💊, conserved from bacteria to eukaryotes! Looks more like an eclair🍩 than a prezel🥨. This protein pastry now makes us wonder- what's the filling!? Huge congrats to the ever-amazing @computingcaitie.bsky.social, now at the @biozentrum.unibas.ch 🧪🧶🧬

Caitie McCafferty @computingcaitie.bsky.social · 15d

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

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Caitie McCafferty @computingcaitie.bsky.social · 14d

Thanks Oli! And yes the resemblance is uncanny 🔮

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Caitie McCafferty @computingcaitie.bsky.social · 14d

Yes it’s a midi shell, I’ll think about how to rephrase/present it better before submitting :)

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Caitie McCafferty @computingcaitie.bsky.social · 14d

I am in a cryo-ET lab now so hoping to figure it out!

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Caitie McCafferty @computingcaitie.bsky.social · 15d

Next step U-ExM!!

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Caitie McCafferty @computingcaitie.bsky.social · 15d

Shout out to the amazing team working on this @ghooger.bsky.social, Ophelia, Evan, Simone, Axel and my PhD advisors David Taylor and @edwardmarcotte.bsky.social for always encouraging me to explore!!!

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Caitie McCafferty @computingcaitie.bsky.social · 15d

We have renamed it to CAGE: Conserved Assembly in Gram-negative bacteria and Eukaryotes; because in addition to shape, it has crazy phylogeny!! And to quote the paper: “The CAGE complex stands as both a new structural archetype and a reminder that the molecular universe is far from fully charted.”

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Caitie McCafferty @computingcaitie.bsky.social · 15d

When I first saw it in my micrographs, I thought it looked like a Philadelphia pretzel. After years of explaining a Philly pretzel and receiving endless pretzel pictures (s/o Jamie) and pretzel swag (s/o @sofie-dot-rec.bsky.social)….

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Caitie McCafferty @computingcaitie.bsky.social · 15d

The early days looking at this complex were spent with @ghooger.bsky.social on the JEOL 2010F in the basement of UT Austin during the pandemic (while watching Real Housewives)

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Caitie McCafferty @computingcaitie.bsky.social · 15d

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

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Reposted by Caitie McCafferty

Ben Engel @cellarchlab.com · 17d

A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾

eLife @elife.bsky.social · 18d

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn

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Reposted by Caitie McCafferty

John Wallingford @jbwallingford.bsky.social · 23d

Side hustle level-up! My book, IN THE BEGINNING, will be published by @harperonebooks.bsky.social in 2027! It's about the human embryo, how it gets built, and what it means for where we come from and where we're going.
@harpercollins.bsky.social (1/2)
@socdevbio.bsky.social
#devbiol
#scicomm

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Caitie McCafferty @computingcaitie.bsky.social · 28d

Congrats Maite!

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Reposted by Caitie McCafferty

Tanmay Bharat @tbharat-lab.bsky.social · Aug 31

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social

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Reposted by Caitie McCafferty

Paul & Virginie - Centriole Lab @centriolelab.bsky.social · Aug 28

Trouble imaging actin in ExM? Meet HAK-Actin, a probe for U-ExM, cryo-ExM & iU-ExM. Enables post-expansion labeling for max signal. www.biorxiv.org/content/10.1...
Soon at @spirochrome.com
Led by O.Mercey and @lreymond.bsky.social, in collab with @dudinlab.bsky.social and @marinelap.bsky.social

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Reposted by Caitie McCafferty

Nature @nature.com · Aug 27

For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began

go.nature.com/3JyRV4S

How did life get multicellular? Five simple organisms could have the answer

Single-celled species that often stick together in colonies have researchers rethinking the origin of animals.

go.nature.com

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Caitie McCafferty @computingcaitie.bsky.social · Aug 27

So cool Ben!!

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Reposted by Caitie McCafferty

Biozentrum, University of Basel @biozentrum.unibas.ch · Aug 4

Apply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibas.ch #fellowship #PhD#Switzerland

Biozentrum PhD Fellowships

Share your passion for life sciences. If you are talented and highly motivated, want to broaden your horizons and are interested in a wide range of research topics, apply for one of the sought after B...

bit.ly

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Reposted by Caitie McCafferty

Paul & Virginie - Centriole Lab @centriolelab.bsky.social · Jul 25

📢 Excited to share our new study in Nature Communications!
We show that the A-C linker safeguards centriole architecture & controls duplication. A big congratulations to Lorène for this beautiful discovery, which represents 4 years of her thesis work.
www.nature.com/articles/s41...

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Reposted by Caitie McCafferty

Mia Konjikusic, PhD @konjikusicmia.bsky.social · Jul 19

‼️🚨Preprint alert! 🚨‼️
Excited to have some of my first works as a postdoc, and first corresponding author (!!), on biorxiv! This was a fun side quest of a project marrying a few things I deeply love, development, cilia, and hormones in the pituitary! Happy reading!

www.biorxiv.org/content/10.1...

Primary cilia and BBS4 are required for postnatal pituitary development

Primary cilia orchestrate several signaling pathways, and their disruption results in pleiotropic disorders called ciliopathies. Bardet Beidl syndrome (BBS), one such ciliopathy, provides insights int...

www.biorxiv.org

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Reposted by Caitie McCafferty

Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · Jul 10

Such a pleasure to be co-organising the #Latsis Symposium this year with Guillermina !

Thanks to all the speakers & sponsors.

And all our teams members who helped make this a reality.

It just felt right.

#Science #WildCells #ProtistsOnSky #Cell #Biology #Biophysics #Behaviour

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