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eLife

@elife.bsky.social

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The funder-researcher collaboration and open-access publisher for research in the life and biomedical sciences. Follow @eLifeCommunity.bsky.social

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eLife @elife.bsky.social · 13d

Openness means more than access.

We’re pleased to announce that we now publish Replication Studies, helping make science more reliable, transparent, and trustworthy.
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7 27

eLife @elife.bsky.social · 1h

The gut-brain connection

Glia cells mediate cytokine signalling between the gut and the brain, linking sleep to inflammation in the gut.

The gut-brain connection

Glia cells mediate cytokine signaling between the gut and the brain, linking sleep to inflammation in the gut.

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eLife @elife.bsky.social · 2h

This support is invaluable to our mission as we work with the community to reform research publishing and assessment, and we hope to welcome more forward-thinking organisations on board soon.

eLife @elife.bsky.social · 2h

These partnerships follow the introduction of our open access agreements to help institutions support their researchers in publishing with eLife, and to help transition away from traditional author fees
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eLife adds publishing agreements to its offering to support an open research future

eLife’s new open access agreements contribute towards a more equitable, inclusive and sustainable system for scientific publishing.

elifesciences.org

eLife @elife.bsky.social · 2h

We’re pleased to partner with two leading UK universities on our uncapped scheme that promotes a more open, equitable and sustainable scientific publishing system buff.ly/TmRgnDE

elife partners with top uk universities, supporting researchers in trying a new route to publication

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eLife @elife.bsky.social · 6h

Inside a thylakoid membrane

The molecular architecture of the thylakoid membrane in a vascular plant has been determined with single-molecule precision.
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Reposted by eLife

Edel Pérez-López 🇨🇦 @edelplopez.bsky.social · 22h

Our @elife.bsky.social Version of Record is now out 🎉 : elifesciences.org/articles/105...

Congratulations to @sohambio.bsky.social , @asimjaved.bsky.social , and @jiaxuwu.bsky.social on this beautiful work. We also wrote an easy-to-read eLife Digest for a general audience 👏

image promoting the paper representing a field, the pathogen and computer predicting proteins

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eLife @elife.bsky.social · 20h

Stability vs flexibility: reshaping archaeal membranes in silico

This ‘fundamental’ study characterises the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model.
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eLife @elife.bsky.social · 1d

True transformation in publishing requires a robust and flexible infrastructure behind the scenes.

Our technology arm builds, integrates and services #OpenSource technologies and infrastructure, collaborating with the wider #OpenScience community.

eLife Technology

Powering real change in the way the research is shared and discovered. Discover how eLife Technology enhances open science with innovative technology, integrated services, and sustainable…

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eLife @elife.bsky.social · 1d

Wnt Signalling: Exploring the origins of a signalling pathway

Wnt Signaling: Exploring the origins of a signaling pathway

The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.

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eLife @elife.bsky.social · 1d

High-resolution #CryoET provides ‘compelling’ evidence for the true 3D architecture of glutamatergic synapses: a complex ‘synaptoplasm’ rather than the textbook postsynaptic density.
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eLife @elife.bsky.social · 1d

Membrane geometry can flip the arrangement of postsynaptic protein condensates, shifting from core-shell structures in solution to reversed layering on membranes. Simulations reveal how spatial constraints control molecular interactions.
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eLife @elife.bsky.social · 2d

2/ They are all recognised for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body. Please join us in congratulating them on this fantastic achievement!

eLife @elife.bsky.social · 2d

1/ We’re delighted to hear that our Reviewing Editor, Shimon Sakaguchi, has been awarded the 2025 Nobel Prize in Physiology and Medicine today alongside colleagues Fred Ramsdell and Mary Brunkell: www.nobelprize.org

The official website of the Nobel Prize - NobelPrize.org

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...

www.nobelprize.org

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eLife @elife.bsky.social · 2d

The koji-fungus, Aspergillus oryzae, traditionally used in Japanese brewing, is now widely used to make enzymes.

It seems its capacity for enzyme production is thanks to its unique ability to proportionally increase cell volume and nuclear number.
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Reposted by eLife

Leo @leowa.bsky.social · 4d

Trained immunity in skin infections: Macrophages and beyond:

doi.org/10.7554/eLif...

Reviewed by Vitka & Merve!

@elife.bsky.social

Trained immunity in skin infections: Macrophages and beyond

Review of the emerging understanding of trained immunity in the skin and how infection-driven cellular processes induce long-lasting immune adaptation and modulate skin barrier integrity.

doi.org

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Reposted by eLife

Killian Hurley @killianhurley.bsky.social · 3d

Fascinating work on the regulation of telomere length - molecular clocks we all have in our cells controlling aging and disease.

Emerging evidence of their role pulmonary fibrosis.

#CureIPF
#Telomeres

@elife.bsky.social
@rcsi.bsky.social
@kaminskimed.bsky.social

eLife @elife.bsky.social · 4d

Your chromosomes have protective ends called telomeres. As they shorten, your cells age. This study reveals how a protein, TRF2, directly regulates telomerase activity to keep telomeres in check.

Keeping telomeres at the right length

The key telomere protein TRF2 helps regulate telomere length by interacting with the telomerase gene TERT in a length-dependent manner.

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eLife @elife.bsky.social · 2d

In the very first days of life, not all embryo cells are truly identical. Small differences in an enzyme called CARM1 guide the timing of cell changes that decide which cells make the embryo, and which make the placenta.
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eLife @elife.bsky.social · 3d

English is the dominant language of science. Does this help us share knowledge? Or does it further exclude the already excluded?

This webinar looks back at the colonial past of science communication and how we can better embrace multilingual science: buff.ly/5f2uPQi

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eLife @elife.bsky.social · 3d

Transcription Factor-Dependent Cancers: Targeting chromatin remodelling complexes to treat uveal melanoma.
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eLife @elife.bsky.social · 3d

In anxiety disorders, the problem may not be an overactive fear system, but rather difficulty in switching off fear when a situation becomes safe and predictable.

Inflexible anxieties

Instead of having an overactive fear system, people with anxiety disorders may suffer from an inability to flexibly reduce the influence of fear as a situation becomes more predictable.

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eLife @elife.bsky.social · 4d

Your chromosomes have protective ends called telomeres. As they shorten, your cells age. This study reveals how a protein, TRF2, directly regulates telomerase activity to keep telomeres in check.

Keeping telomeres at the right length

The key telomere protein TRF2 helps regulate telomere length by interacting with the telomerase gene TERT in a length-dependent manner.

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eLife @elife.bsky.social · 4d

The physics of flight becomes more difficult the smaller animals are. So how does a tiny hoverfly keep up? By flapping harder?

New research suggests they employ a smarter strategy.

Adaptations in wing morphology rather than wingbeat kinematics enable flight in small hoverfly species

Small hoverflies compensate for size-related flight challenges through evolutionary changes in wing shape rather than altered wingbeat kinematics.

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eLife @elife.bsky.social · 4d

🌍 Insect #biodiversity is declining worldwide, with agriculture being a major contributor to this decline. It’s thought that strip cropping, an alternative to monocultures, could help, but is there any evidence? #Ecology

Strip cropping for biodiversity

Strip cropping can increase insect biodiversity without reducing crop yield and productivity.

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eLife @elife.bsky.social · 5d

Get to the heart of what research really means.

eLife Insight Articles explain the latest studies and why they matter.

Explore them all today: buff.ly/AuJrkKL

eLife @elife.bsky.social · 5d

🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
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