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Konstantinos Miti @mitisbio.bsky.social · 1d

Our calcium paper is out in PLOS Biology!
Check it out! #Calcium #Embryo #Development

PLOS Biology @plosbiology.org · 1d

During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4

Epiblast Ca2+ waves propagate from the apical to basal domain. The images show selected time points from movies of E5.5 GCaMP6f embryos imaged using a ZEISS lattice light-sheet 7 microscope. Top row: An example of an epiblast wave involving a large proportion of the tissue captured by imaging a volume of the embryo at 20-s intervals. A total of 9/16 embryos showed at least one epiblast Ca2+ wave. Bottom row: Faster imaging at 5-s interval revealed that the Ca2+ wave in the epiblast can be preceded by a transient in a neighboring VE cell—this was observed in 5/19 events from 9 embryos (white arrowheads).

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Reposted by Konstantinos Miti

Dr Jacinta Kalisch-Smith @jkalism.bsky.social · Jun 2

Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social.

journals.biologists.com/dev/article/...

@idrm.ox.ac.uk Funded by the @thebhf.bsky.social

Feto-placental blood vessel development

Summary: This Review contains an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field.

journals.biologists.com

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Reposted by Konstantinos Miti

Young Embryologist Network @yen-network.bsky.social · May 20

@mitisbio.bsky.social
from @ox.ac.uk spoke about the dynamics of calcium oscillations and their role during peri-gastrulation in the mouse embryo

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Reposted by Konstantinos Miti

Young Embryologist Network @yen-network.bsky.social · May 5

We are happy to announce student and postdoc speakers. Thanks to all who submitted an abstract!
#yen2025

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Reposted by Konstantinos Miti

Young Embryologist Network @yen-network.bsky.social · May 2

This #FluorescenceFriday feels like fluorescence xmas!

Thanks for all your submissions to the YEN Image Competition. Excited to see so many spectacular visualisations of embryonic development and stem cell biology!
#YEN2025

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Konstantinos Miti @mitisbio.bsky.social · Mar 26

Very excited to share our work on calcium dynamics during early mouse development at #biologists100. Stop by Poster 182 to say hi and learn more!

@biologists.bsky.social @the-node.bsky.social @focalplane.bsky.social @bsdb.bsky.social @srinivas-lab.bsky.social

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Reposted by Konstantinos Miti

Selin Tüzüner @selintuzuner.bsky.social · Feb 14

Happy Valentine's day from the Simões group❣️ @simoesfilipa.bsky.social
#spreadthelove#mendingbrokenhearts#cardiacorganoids

Image taken by @mitisbio.bsky.social

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Reposted by Konstantinos Miti

Srinivas Lab @srinivas-lab.bsky.social · Dec 6

Happy to share our latest review by @shifaant.bsky.social with @cwhanna.bsky.social. A detailed look at extraembryonic tissues – the 'other half' of the conceptus.

www.nature.com/articles/s41... @natrevmcb.bsky.social

Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology

During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...

www.nature.com

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Reposted by Konstantinos Miti

Filipa Simões @simoesfilipa.bsky.social · Dec 5

Truly excited about this new endeavour- co-leading the Oxford Organoid Hub with @rdmoxford.bsky.social colleague Chris Toepfer! Big thanks to @oxforddpag.bsky.social & BHF CRE for believing in our vision!

Pretty pics by force-of-nature DPhil students Selin Tüzüner & @mitisbio.bsky.social @ox.ac.uk

Human iPSC-derived cardiac organoids, brightfield and phalloidin-stained images

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Reposted by Konstantinos Miti

Srinivas Lab @srinivas-lab.bsky.social · Nov 18

Happy to have the Srinivas lab on Bluesky!

Even our embryos are starting to feel a little festive in the Srinivas lab! We are excited to share our new bioRχiv pre-print – investigating the role of calcium in the early embryo
www.biorxiv.org/content/10.1...

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Reposted by Konstantinos Miti

bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Nov 15

Calcium signalling is required for anterior patterning in the mouse embryo https://www.biorxiv.org/content/10.1101/2024.11.14.623160v1

Anterior-Posterior axis formation in the mouse embryo requires the active migration of the DVE cell

www.biorxiv.org

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