Lightnews — Scholar-powered news

Filipa Simões

@simoesfilipa.bsky.social

3.1K followers 700 following 110 posts

Posts Media Videos Starter Packs

Pinned

Filipa Simões @simoesfilipa.bsky.social · May 8

Just published! Our Review on how immune cells masterfully orchestrate heart development and regeneration. Beyond fighting pathogens, they're actually building & repairing your heart! Learn how cutting-edge technologies are driving therapeutic opportunities here www.sciencedirect.com/science/arti...

Immune-mediated cardiac development and regeneration

The complex interplay between the immune and cardiovascular systems during development, homeostasis and regeneration represents a rapidly evolving fie…

www.sciencedirect.com

1 11 24

Reposted by Filipa Simões

Miguel Ramalho-Santos @mrsantos.bsky.social · 22h

John Gurdon was a true giant:
- founder of cell reprogramming;
- founder of molecular embryology;
- unabashed advocate for basic research;
- advisor to numerous successful trainees/PIs;
- gentle human that touched so many.
In dark times with science under attack, let his vision be a guiding light.

Katherine Brown @katherine-brown.bsky.social · 1d

Very saddened to hear of John Gurdon’s passing. I’ve been lucky enough to interact with him at multiple points through my career - from undergrad lectures, through his position as former Chair of @biologists.bsky.social’s Board of Directors, and as an author at @dev-journal.bsky.social.

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

www.cam.ac.uk

1 11 47

Reposted by Filipa Simões

Emma Rawlins @labrawlins.bsky.social · 22h

Saddened to learn of the death of John Gurdon today. He was the supreme scientist. And truly inspirational lecturer and speaker. The Gurdon Institute @gurdoninstitute.bsky.social has been a wonderful place to run a lab - and he will be truly missed.

www.gurdon.cam.ac.uk/nobel-laurea...

Nobel Laureate Professor Sir John Gurdon Dies Aged 92 – Gurdon Institute

www.gurdon.cam.ac.uk

1 3 32

Reposted by Filipa Simões

Sumru Bayin @sumrubayin.bsky.social · 1d

John Gurdon's research inspired me in my own scientific pursuits as a stem cell biologist. Starting my lab at
@gurdoninstitute.bsky.social was therefore particularly exciting. Seeing him around daily only underscored his admirable dedication to science and research. RIP John.
tinyurl.com/nha6z25h

1 4 24

Reposted by Filipa Simões

Michael Hendricks 🇨🇦 @michaelhendricks.bsky.social · 1d

"The work I was involved in had no obvious therapeutic benefit. It was purely of scientific interest. I hope the country will continue to support basic research even though it may have no obvious practical value."
- John Gurdon

Katherine Brown @katherine-brown.bsky.social · 1d

Nobel Laureate Professor Sir John Gurdon dies aged 92

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.

www.cam.ac.uk

1 11 41

Reposted by Filipa Simões

New School of the Anthropocene @nsota.bsky.social · 1d

With grateful thanks for the life of the Nobel scientist, Sir John Gurdon: a man of immeasurable kindness & humility as well as a visionary biologist.

www.magd.cam.ac.uk/news/profess...

2 4

Reposted by Filipa Simões

Katherine Brown @katherine-brown.bsky.social · 1d

It’s no underestimate to say that he founded a whole field of biology - reprogramming - and his influence on the #devbio field and community has been enormous. He’ll be sorely missed, but his legacy will live on.

2 13

Reposted by Filipa Simões

Current Biology @currentbiology.bsky.social · 1d

“For Gurdon to continue in biology would be a complete waste of time both for him and for those who would have to teach him”

He proved them wrong! RIP John Gurdon

www.cell.com/current-biol...

John Gurdon

John Gurdon is at the Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology in Cambridge. Educated at Eton and Christ Church, Oxford, he changed from classics to zoology. Dur...

www.cell.com

14 34

Filipa Simões @simoesfilipa.bsky.social · 23h

A huge loss for our community, truly sad news…

Reposted by Filipa Simões

Sally Lowell @cellysally.bsky.social · 1d

An inspiration to so many of us. I can say with no hesitation that reading John Gurdon's papers as an undergraduate changed my life. I was reprogrammed from a slightly bored biochemistry student into a person with a life-long love of developmental biology. I have much to thank him for.

1 21

Reposted by Filipa Simões

James Briscoe @jamesbriscoe.bsky.social · 1d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

7 100 180

Reposted by Filipa Simões

David K Smith @professor-dave.bsky.social · 1d

A remarkable transformation in @rsc.org prizes.
30% of prizes recognise teams rather than individuals (up from 5%).
36% of prize-winners are early-career (up from 4%)
38% of prize winners are women (up from 25%)
Twice as many prizes for work outside universities.
www.rsc.org/policy-and-c...

Reshaping recognition: evolving how we celebrate excellence

A multi-year journey to transform our prizes

www.rsc.org

2 14 48

Reposted by Filipa Simões

Jain_Akanksha_ @akanksha-jain.bsky.social · 1d

🧠 Join us @uzh-ch.bsky.social ! We are a new lab looking for PhDs, Postdocs & Master’s students interested in studying how human neural systems emerge & go awry using brain organoids, light-sheet imaging & genomics. 🚀 Deadline for LSZGS 1st Nov! www.lifescience-graduateschool.uzh.ch/en.html.

11 19

Reposted by Filipa Simões

Konstantinos Miti @mitisbio.bsky.social · 1d

Our calcium paper is out in PLOS Biology!
Check it out! #Calcium #Embryo #Development

PLOS Biology @plosbiology.org · 1d

During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4

Epiblast Ca2+ waves propagate from the apical to basal domain. The images show selected time points from movies of E5.5 GCaMP6f embryos imaged using a ZEISS lattice light-sheet 7 microscope. Top row: An example of an epiblast wave involving a large proportion of the tissue captured by imaging a volume of the embryo at 20-s intervals. A total of 9/16 embryos showed at least one epiblast Ca2+ wave. Bottom row: Faster imaging at 5-s interval revealed that the Ca2+ wave in the epiblast can be preceded by a transient in a neighboring VE cell—this was observed in 5/19 events from 9 embryos (white arrowheads).

9 14

Reposted by Filipa Simões

The Guardian @theguardian.com · 1d

Scientist learns he has won Nobel prize while on digital detox in US mountains

Fred Ramsdell’s wife switched on her phone and screamed – it was full of messages congratulating her husband Out on a digital detox in the western US backcountry, scientist Fred Ramsdell was startled when his wife let out a yell. He feared she had spotted a grizzly bear, only to discover a far better surprise – he had won the Nobel prize in medicine. The Nobel committee had been unable to reach the immunologist, whose phone was on airplane mode as he was on a hiking and camping trip, but finally got through to the couple early on Tuesday morning, Swedish time. Continue reading...

www.theguardian.com

3 26 150

Reposted by Filipa Simões

Development @dev-journal.bsky.social · 1d

Issue 18 is complete!

On the cover: Clones on Drosophila retina with activated Mbt kinase (pink), expanding Sdk protein (yellow) from tri- to bi-cellular adheren junctions & distorting the ommatidial lattice (cyan).

See Research Article by Gandhi et al.

journals.biologists.com/dev/article/...

1 5 20

Reposted by Filipa Simões

Rita Strack @ritastrack.bsky.social · 1d

What an amazing opportunity to do impactful work in bioimage analysis!!!!

Jean-Yves Tinevez @jytinevez.bsky.social · 1d

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

forum.image.sc

7 11

Reposted by Filipa Simões

Naomi Moris @nmoris.bsky.social · 2d

Fully-funded 4-year PhD Opportunities available at the @crick.ac.uk , including a project in our lab on human #embryomodels Feel free to share with anyone interested, and apply through the online portal before 5th November! 👏

www.crick.ac.uk/careers-stud...

Moris Lab | Investigating human trunk development using stem cell-based embryo models

www.crick.ac.uk

14 20

Reposted by Filipa Simões

Kevin Wright @kevinmawright.bsky.social · 2d

Thanks to @currentbiology.bsky.social I now know that elephantnose fish have something called a "Schnauzenorgan" that is loaded with mechanosensory nerve fibers

Biology is amazing.

2 3 18

Reposted by Filipa Simões

OxfordDPAG @oxforddpag.bsky.social · 2d

DPAG’s David Paterson, Neil Herring and international co-authors have published a review article: Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system www.dpag.ox.ac.uk/news/review-...

Review article published: Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system

www.dpag.ox.ac.uk

1 2

Reposted by Filipa Simões

Erdinc Sezgin @sciezgin.bsky.social · 1d

Cell Physics community is missing Jochen Guck deeply.. He was a very kind and generous person, one of the most creative minds, and always ready to help everyone in the field.. He inspired many of us.. He will always be missed..

1 1 20

Reposted by Filipa Simões

SEBD @sebioldev.bsky.social · 2d

We are very pleased to announce our joint meeting with the German @gfeev.bsky.social and the Dutch Developmental Biology Societies, which will take place in Potsdam from the 10-13th of March 2026. Registration is now open! www.uni-potsdam.de/en/gfe-meeti...

2 28 46

Reposted by Filipa Simões

Raquel Fueyo @fueyoraquel.bsky.social · 2d

⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab

3 23 79

Reposted by Filipa Simões

Dinis Calado @diniscalado.bsky.social · 2d

Want to see immune cells in 3D? We’ve published a protocol for 5-plex 3D imaging of whole lymph nodes, revealing germinal centers at single-cell resolution. So many possibilities ahead! Congratulations Victoire Boulat!

tinyurl.com/y9ekha8c

#Microscopy #Immunology #SpatialBiology

Quantitative 3D analysis of germinal centers, plasma cells, and follicular T cells post immunization. Representative image of 3D rendered surfaces created with Imaris including naïve B cells (blue), the T cell zone (green), follicular dendritic cell (FDC) network (white), germinal centers (red), follicular T cells (green) and plasma cells (magenta). Scale bar = 200 μm. Credit Victoire Boulat.

1 5 18

Reposted by Filipa Simões

Bart Deplancke @bartdeplancke.bsky.social · 2d

🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China

Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics

This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.

www.nature.com

2 49 140

Reposted by Filipa Simões

Gautam Dey @gautamdey.bsky.social · 4d

If you’re applying to your dream lab for an internship/PhD/postdoc, always send a second email 1-2 weeks after the first one if you don’t hear back.

I promise we will be grateful rather than annoyed. My email inbox is a disaster and I’m quite junior - and very few of us have secretarial support

2 44 150