Fully-funded 4-year PhD Opportunities available at the @crick.ac.uk , including a project in our lab on human #embryomodels Feel free to share with anyone interested, and apply through the online portal before 5th November! 👏

www.crick.ac.uk/careers-stud...

Well done for writing this Bethan! A really interesting read and some important points here on how we can all do better. 👏

Marvellous send off for @amartinezarias.bsky.social ‘s lab, perfectly located in Gaudi’s La Pedrera. I took no pictures as I was too busy hugging old friends, but the organisers incl @dias-andre.bsky.social pulled off something rly special. Community in science is the real joy of the work we do! 💕

Do you have friends with questions about fertility? Egg freezing? Embryo research? IVF? Stem Cells? If you're UK-based this Friday, the BBC are hosting a Question of Science and tickets are still available. PLUS you can submit a question in advance to ask the panelists 🎤
shorturl.at/BCTW7

Thanks @cellysally.bsky.social ! It's shaping up to be a great meeting (no pun intended...) so I'm looking forward to it ☺️

Congrats Ina! Very well deserved, and so lovely to read your interview in the attached link 👏 hope you're celebrating well! 🍾

Fascinating story-telling on embryo research from the @nytimes.com "what once grew or failed to grow unseen is out in the open, under examination, up for debate"

www.nytimes.com/interactive/...

🧫Looking for a PhD to start Autumn 2025? We're recruiting! 🧪

The project will focus on using #embryomodels to explore #development & could cover a range of specific questions. Please RT! 🙏

Apply via the portal, and get more details here: www.crick.ac.uk/careers-stud...

Here is the 2025 embryo alphabet from alligator to zebrafish. Developmental biology is stunning & leads to important discoveries for human medicine.
@socdevbio.bsky.social

The Y chromosome is critical for sex determination, but what do the genes on the Y actually DO? And how is this important for spermatogenesis? Tour-de-force paper from our colleagues @lab-turner.bsky.social ! 👏https://www.science.org/doi/10.1126/science.ads6495

This work was led by postdoc, Komal, and research scientist, Louise, @theCrick with the help of lots of others. The link to our biorxiv manuscript can be found here: biorxiv.org/cgi/content/... Feedback welcome, thanks for reading! 🙏 (7/7)

Thus, we found feedback in both directions, causing patterning important for organogenesis. The simple ‘modularity’ of hTLS that let us investigate in the presence/absence of certain tissues, could help us understand co-development, esp in a human context (6/7)

So we looked at signalling between the 2 tissues. As predicted from animals, RA is needed for PAX6+ but not neurogenesis. Plus, ALDH1A2 (which synthesises RA) was only in the medial somite - implying neural tube signalling was reciprocally patterning the somites! (5/7)

BUT without a notochord, hTLS are dorsal. Exposure to SAG makes them ‘ventralise’ dose-dependently. Doing this, we noticed something interesting… the NT cells next to the somites were different from the other side. Communication between tissues was setting up an axis... (4/7)

hTLS show self-organised wavefront signalling and oscillations to form somites; Neuromesodermal progenitors support elongation and become depleted over time; HOX genes show we’re at thoracic/lumbar regions… (3/7)

hTLS are an embryo model that mirrors development using human cells. We used 7 cell lines + optimised to make it robust. The neural tube forms through a 2ndry neurulation-like process. Bioinformatically, hTLS cells are most like Carnegie Stage13-14 embryos (~day 28!) (2/7)

Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)

@mrc-lms.bsky.social is hiring! Are you looking to start your own research group? Come & join us!

Fantastic research, wonderful facilities & super supportive colleagues. Deadline 13th Jan.

Get on it!

lms.mrc.ac.uk/work/vacanci...

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

For the dev bio crowd : there is a call for junior group leader at Institut Pasteur in Paris and one of the axis covered is related to development. Come and join us in this exciting place and become one of our colleague @devstempasteur.bsky.social
Please RT !!
research.pasteur.fr/fr/call/call...