Levayer Lab
@levayerr.bsky.social
3.3K followers 480 following 130 posts
Epithelial cell death, cell extrusion, self-organisation, mechanotransduction and many other things
Posts Media Videos Starter Packs
Reposted by Levayer Lab
mpi-scienceoflight.bsky.social
With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.

mpl.mpg.de/news/article...
@fau.de

📸 Stephan Spangenberg
Professor Jochen Guck, Director at the Max Planck Institute for the Science of Light (MPL), He headed the division “Cell Physics” at MPL and the Max-Planck-Zentrum für Physik und Medizin (MPZPM).
Reposted by Levayer Lab
ebisuyamiki.bsky.social
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
levayerr.bsky.social
Great combo of nice basic science and very timely topic ! Will read the preprint for sure.
Reposted by Levayer Lab
kuba-sedzinski.bsky.social
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
Reposted by Levayer Lab
nveits.bsky.social
How is developmental speed regulated ? 🪰

Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.

www.biorxiv.org/content/10.1...

A big thanks to everyone involved!
Reposted by Levayer Lab
pasteuredu.bsky.social
⌛1 month left to apply – 2025 PPU call for candidates

We invite you to discover 4 Develpmental & Stem Cell Biology projects and 3 Immunology projects👇

🕰️Application deadline: October 20, 2025
📍Program starts: October 2026

Discover all the projects (50+) & apply: www.pasteur.fr/en/education...
levayerr.bsky.social
We only had a very minor contribution to this story with Alexis, but definitly worth a reading for those interested by patterning, precision and refinment. Nice combining of quantitative live imaging, modeling and optogenetics to dissect vein patterning dynamics
www.cell.com/developmenta...
Signaling-dependent refinement of cell fate choice during tissue remodeling in Drosophila pupal wings
Herszterg et al. show that during morphogenesis of the Drosophila pupal wing, a wave of Notch signaling activity updates cell fates to ensure robust and precise patterning of wing veins.
www.cell.com
Reposted by Levayer Lab
sarawickstrom.bsky.social
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Computational image analyst (m/f/d)
The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a
jobs.mpi-muenster.mpg.de
Reposted by Levayer Lab
pritiagarwal.bsky.social
🚨 The International Developmental Mechanics Zoom Seminar Series is back on Sept 25!
🎤 We have an exciting line-up of speakers this fall. See the image below for details
🌐 Website: sites.google.com/view/devmech...
📝 Interested in presenting? Sign up here: tinyurl.com/2munv5bv
levayerr.bsky.social
A though provocative idea potentially connecting cell metabolic state and sensitivity to mechanical stress (and thus potentially relevant for cell competition)
levayerr.bsky.social
Epithelial crowding drives membrane depolarisation by ENaC/Na+ entry which triggers rapid volume loss, piezo activation and live cell extrusion. Importantly, low intracellular ATP primes cells for live extrusion by preventing the restoring of mb polarisation.

www.nature.com/articles/s41...
Energy deficiency selects crowded live epithelial cells for extrusion - Nature
Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.
www.nature.com
levayerr.bsky.social
Interesting changes for the ERC evaluation, including an extension of the eligibility period for StG and CoG (now up to 10 and 15 years post phd respectively). Worth a reading for those intending to apply in the coming years (and nice to see that the council keeps trying to improve the process)
erc.europa.eu
Based on feedback from applicants, reviewers and broader research community, the ERC Scientific Council decided to make changes in the 2026–27 calls for proposal for research funding.

More details from the ERC President 👉 europa.eu/!hP3WWF

What’s your take on this? Tell us! 👇
Reposted by Levayer Lab
anaisbailles.bsky.social
Very happy that the first article from my postdoc work in the Tomancak lab is now published @PNAS! www.pnas.org/doi/10.1073/.... We studied the self-organization of actin in aggregates made from Hydra cells. Thread below (1/9)
levayerr.bsky.social
I may have a biased interpretation here, but I suspect the background of @danielkrueger.bsky.social in fly morphogenesis brought a lot here (congrat for the impressive work !) , a good example of virtuous background mixing and work built on important conceptual/technical premise from model organism
levayerr.bsky.social
This is very complementary with the recent preprint of @xaviertrepat.bsky.social and Maria Matejcic using 2D organoids and providing 3D mechanical characterisation of the process
levayerr.bsky.social
Important story dissecting the mechanism of gut cell extrusion using organoids. Local heterogeneity of tension promotes live extrusion and basal relaxation is sufficient to kick the cell out. Nice combination of optogenetics and live imaging to demonstrate this
www.science.org/doi/abs/10.1...
Reposted by Levayer Lab
gaellel.bsky.social
We (with @nicolasdray.bsky.social @zenlabpasteur.bsky.social) are happy to release officially FishFeats, our #napari plugin to streamline 3D smFish/RNA quantification! 🎊
Available here: github.com/gletort/Fish... user documentation: gletort.github.io/FishFeats/
Reposted by Levayer Lab
thibautbrunet.bsky.social
Beautiful story that combined mechanobiology, evolution, and the power of fly (opto)genetics to make sense of the cephalic furrow. It was a pleasure writing the News & Views. No doubt this is still just the beginning for the field of mechano-evo-devo! Hats off to all involved
paveltomancak.bsky.social
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
levayerr.bsky.social
Congrat, looks like a cool project !
Reposted by Levayer Lab
ritamateus.bsky.social
We have a fully funded 3y postdoc position open!!!! Come join us @mpi-cbg.de and @poldresden.bsky.social to understand the role of Membranes in Controlling Biogenic Crystallization :) this is part of our #HFSP funded project with @noemijimenezrojo.bsky.social and @vmonje.bsky.social! Applications👇
maxplanck.de
The #MaxPlanckPostdocProgram offers a guaranteed contract of at least 3 years, targeted mentoring, and career workshops. The call for applications is open now! 🚀 Take advantage of this opportunity and browse the job vacancies. www.mpg.de/en/max-planc...
Group photo of postdocs conducting research at a Max Planck Institute
Reposted by Levayer Lab
pasteur.fr
🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry.

Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, [email protected], PPU-EID @upcite.bsky.social & more 🧬

Register now ✍️ www.pasteur.fr/en/education...
Pasteur-Paris University International Doctoral Programme, The call for enrollment of students in October 2026 will be open from September 1st to October 20th, 2025