Lightnews — Scholar-powered news

Miki Ebisuya @ebisuyamiki.bsky.social · 5h

It’s my first official collaboration project at PoL TU Dresden! I couldn’t be luckier to have you right next door!

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Miki Ebisuya @ebisuyamiki.bsky.social · 5h

Shuting, Your determination is the driving force behind this project’s success!

Miki Ebisuya @ebisuyamiki.bsky.social · 9h

We hope you enjoy this cross-species exploration of brain tissue mechanics!
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doi.org/10.1101/2025...

Species-specific basal fluidization shapes early forebrain development

The human forebrain exhibits an expanded surface area compared with other great apes. Despite rapid progress in dissecting species-specific gene expression programs and cell lineages, the tissue-level...

doi.org

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Miki Ebisuya @ebisuyamiki.bsky.social · 9h

Overall, our findings identify basal fluidity a novel mechanical hallmark of early human forebrain development, which may contribute to the tangential surface expansion unique to humans.
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Miki Ebisuya @ebisuyamiki.bsky.social · 9h

Consistent with droplet motility, cell rearrangements occur more frequently in the basal region of human neuroepithelia, confirming basal fluidity. Such active rearrangements likely help accommodate newly divided nuclei migrating from the apical side.
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Miki Ebisuya @ebisuyamiki.bsky.social · 9h

Inhibiting nuclear movement fluctuations through cell cycle inhibitors or N-cadherin overexpression suppresses basal fluidity in human neuroepithelia.
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Miki Ebisuya @ebisuyamiki.bsky.social · 9h

We also found that human neuroepithelia have a lot of intercellular spaces in the basal region, constituting a permissive environment for basal fluidity.
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Miki Ebisuya @ebisuyamiki.bsky.social · 9h

We found that basal fluidity is driven by greater fluctuations in nuclear movement within the basal region of human neuroepithelia.
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Miki Ebisuya @ebisuyamiki.bsky.social · 9h

Although human, gorilla, and mouse neuroepithelia appear similar, oil microdroplets move dynamically only in the basal region of human neuroepithelia. This droplet motility ceases as neurogenesis began.
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Miki Ebisuya @ebisuyamiki.bsky.social · 9h

This work showcases Shuting @shutingxu.bsky.social’s creativity and dedication & a wonderful collaboration w/ Otger @campaslab.bsky.social who kept pushing interdiscipline boundaries!
Grateful for supportive environemnts at [email protected], [email protected], [email protected] 2/

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Miki Ebisuya @ebisuyamiki.bsky.social · 9h

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...

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Reposted by Miki Ebisuya

Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 1d

Jonathan Rodenfels @mpi-cbg.de, Pablo Sartori @gimmfoundation.bsky.social, and Tommaso Cossetto identified two thermodynamic rules governing the growth and energy utilization of single-celled organisms. Publication in @nature.com Communications. www.mpi-cbg.de/news-outreac...

Cracking organisms’ energy code

Researchers define rules governing how growing microorganisms use energy efficiently

www.mpi-cbg.de

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Reposted by Miki Ebisuya

Juanma García-Arcos @juanmagararc.bsky.social · 3d

🚨 New preprint out!
“Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social
We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies.

www.biorxiv.org/content/10.1...

Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM

Flipper-TR is a membrane dye sensitive to lipid packing widely used to probe membrane tension in live cells via fluorescence lifetime imaging microscopy (FLIM). However, no consensus currently exists ...

www.biorxiv.org

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Reposted by Miki Ebisuya

Magdalena Skipper @magdalenaskipper.bsky.social · 2d

Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi for winning the Nobel Prize in Physiology or Medicine!

🧪

#Nobel2025

www.nature.com/articles/d41...

Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

www.nature.com

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Reposted by Miki Ebisuya

Thibaut Brunet @thibautbrunet.bsky.social · 3d

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

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Reposted by Miki Ebisuya

NPR @npr.org · 7d

JUST IN: Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.

Jane Goodall, legendary primatologist, has died at age 91

Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.

n.pr

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Miki Ebisuya @ebisuyamiki.bsky.social · 4d

Really torn about Sanae Takaichi becoming Japan's first female prime minister. Historic moment, yes! But her ultra-conservative stance worries me. Ms Takaichi's against same-sex marriage, immigration, and even keeping maiden names(important for researchers)
bbc.com/news/article...

Sanae Takaichi set to become Japan's first female prime minister

Takaichi is a long-time admirer of Margaret Thatcher, but many female voters do not see her as an advocate for progress.

bbc.com

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Reposted by Miki Ebisuya

Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 5d

Finally .. incredible much awaited wok on deriving avian naive ESCs

“Derivation of embryonic stem cells across avian species”

www.nature.com/articles/s41...

Derivation of embryonic stem cells across avian species - Nature Biotechnology

Embryonic stem cells for chicken and seven other avian species are derived.

www.nature.com

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Reposted by Miki Ebisuya

Raquel Fueyo @fueyoraquel.bsky.social · 7d

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

A human-specific regulatory mechanism revealed in a pre-implantation model

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

rdcu.be

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Reposted by Miki Ebisuya

Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Reposted by Miki Ebisuya

Guillaume Charras @gcharras.bsky.social · 9d

Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.

More here: elifesciences.org/reviewed-pre...

elifesciences.org

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Reposted by Miki Ebisuya

Teresa Rayon @trayon.bsky.social · 10d

This meant that degradative machineries may be in charge:
✔️ differential abundance & stability of proteasomal particles
✔️ higher proteasomal activity in 🐭 compared to 👤 embryonic spinal cord

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Reposted by Miki Ebisuya

Nobu Hamazaki @nobuhamazaki.bsky.social · 12d

New paper from my lab and @jshendure.bsky.social lab! Led by the brilliant @zukailiu.bsky.social and @cxqiu.bsky.social. We tackled how anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid). (1/n) www.biorxiv.org/content/10.1...

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Reposted by Miki Ebisuya

EMBL @embl.org · 16d

EMBL scientists found metabolism controls embryonic development tempo through signalling in a way separate from its established metabolic function.

More research related to this signalling could illuminate how it guides cell fate, developmental timing -- even disease.

www.embl.org/news/science...

When metabolism provides more than fuel | EMBL

A new study observed the key signalling role that metabolism plays in controlling the tempo of development.

www.embl.org

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Miki Ebisuya @ebisuyamiki.bsky.social · 16d

That’s my old office!!! So cool to still see my name on the plate!

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