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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 6h

A Palestinian, son of Palestinians displaced from Gaza (Al-Masmiyya) to Jordan, wins the Nobel Prize in Chemistry... Professor Omar Munis Yaghi from the University of Berkeley!!

..Some members of the Yaghi family are still under the rubble in Gaza!

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Reposted by Jacob (Yaqub) Hanna - يعقوب حنا

Cell Stem Cell @cp-cellstemcell.bsky.social · 6d

Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs

Hanna and colleagues show that signaling pathway modulation amplifies the inherent flexibility of genetically unmodified mouse naive PSCs to adopt extra-embryonic cell fate potential. This endows them with the competence to generate up to E8.5–E8.75 transgene-free stem cell-derived embryo models (TF-SEMs) that complete gastrulation and initiate organogenesis within complex extra-embryonic compartments ex utero.

dlvr.it

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Reposted by Jacob (Yaqub) Hanna - يعقوب حنا

Cell Stem Cell @cp-cellstemcell.bsky.social · 1d

Building the start: Unlocking advanced stem cell-based embryo models

Two recent studies from the Silva and Hanna groups optimized chemical induction and culture conditions to derive extraembryonic lineages directly from embryonic stem cells (ESCs) without transgenes, enabling mouse stem cell-based embryo models (SCBEMs) to reproducibly advance to the E8.5–E8.75 stage.

dlvr.it

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 4d

Last day of intense science discussions and presentations at the HFSP Science Summit Japan was held in Kyoto university. It has been an amazing 5 days of listening to great scientists from Japan and all over the world. An unforgettable visit.

Human Frontier Science Program @hfspo.bsky.social · 4d

🧪 The #HFSPSummitJapan ended today in Kyoto
✨ Nobel Laureates & Nakasone Awardees shared insights with young researchers
🧬 Svante Pääbo gave a fascinating keynote on human evolution.
👩‍🔬 A lively poster session closed the day.
What a journey! What a Summit! More highlights soon 🙂
#sts

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 4d

Thanks to Leqian Yu and co and @cp-cellstemcell.bsky.social for highlighting recent work, including ours, on transgene free mouse high fidelity post gastrulation SEMs www.cell.com/cell-stem-ce...

Building the start: Unlocking advanced stem cell-based embryo models

Two recent studies from the Silva and Hanna groups optimized chemical induction and culture conditions to derive extraembryonic lineages directly from embryonic stem cells (ESCs) without transgenes, e...

www.cell.com

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 5d

Another great day in Japan science summit with Intriguing science and science policy discussions at University of Tokyo.

Human Frontier Science Program @hfspo.bsky.social · 5d

🧪 The #HFSPSummitJapan High-Level Event has started at The University of Tokyo 🇯🇵!
Nobel Laureates, Science Leaders, HFSP Nakasone Awardees & Japanese researchers debating innovation, collaboration, and the future of life sciences. 🌟 #HFSPsciencesummit #sts

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 5d

Finally .. incredible much awaited wok on deriving avian naive ESCs

“Derivation of embryonic stem cells across avian species”

www.nature.com/articles/s41...

Derivation of embryonic stem cells across avian species - Nature Biotechnology

Embryonic stem cells for chicken and seven other avian species are derived.

www.nature.com

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 7d

This was a real fun event!

Human Frontier Science Program @hfspo.bsky.social · 7d

🧪 The HFSP Science Summit Japan has officially kicked off today at Tohoku University in Sendai! An inspiring start with outstanding researchers & young scientists reflecting on collaboration and innovation in life sciences. 🌍✨ #sts #HFSPSummitJapan

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · 10d

EEE meeting is BACK! Early Embryogenesis & Epigenetics conference in Berlin 02/2026.
Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open -
w.molgen.mpg.de/embryo2026

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Reposted by Jacob (Yaqub) Hanna - يعقوب حنا

Denis Duboule @denisduboule.bsky.social · 18d

Having fun @amartinezarias.bsky.social party! 🙏🏻🎉💐 Great meeting #InHoxWeSortOfTrust

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Reposted by Jacob (Yaqub) Hanna - يعقوب حنا

Human Frontier Science Program @hfspo.bsky.social · Sep 3

🧪 HFSP & partners present Science Summit Japan 2025!
🗓️Oct 1–4 📍Tohoku University, RIKEN, UThe University of Tokyo & Kyoto University.
✨ Nobel Laureates, HFSP Nakasone Awardees & top researchers engaging with young scientists.
More info 👉https://bit.ly/45WGRWM

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 28

Shout out re @isscr.org awards nomination deadline SEP 30 2025! Please note the great revision & efforts that have been made to recognize excellence in industry, policy makers, clinical translation etc & from across the globe. Self-nominations are equally welcomed!
www.isscr.org/awards

Awards + Nominations — International Society for Stem Cell Research

The ISSCR Awards portfolio recognizes outstanding achievements and research potential in the field of stem cell research around the world. The ISSCR awards honor scientists’ innovative work to harness...

www.isscr.org

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 27

Super congrats dear Richard

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Reposted by Jacob (Yaqub) Hanna - يعقوب حنا

Development @dev-journal.bsky.social · Aug 15

Pathway to Independence – an interview with Joaquín Navajas Acedo.

In this interview, @mads100tist.bsky.social talks about about his research vision, zebrafish and the importance of community:

journals.biologists.com/dev/article/...

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 14

Tnx to @hfspo.bsky.social for humbling opportunity to present our work #HFSPNakasoneAward lecture.
Tnx to Hanna lab, current & former members, collaborators, mentors. @weizmanninstitute.bsky.social for critical backing, @isscr.org for guidelines, funding agencies & dear philanthropists for funding

Human Frontier Science Program @hfspo.bsky.social · Aug 14

🧪 From petri dish to embryo model: @jacob-hanna.bsky.social work shows how naïve pluripotent stem cells can self-organize into advanced developmental stages.
The 2025 #HFSPNakasoneAward lecture reveals the science behind synthetic embryo models.

Full lecture 🎥 👉 zurl.co/Tgf4f
#sts

HFSP Nakasone Award 2025 Lecture – Jacob Hanna on Synthetic Embryo Models

In this official HFSP Nakasone Award lecture, Professor Jacob (Yaqub) Hanna of the Weizmann Institute of Science shares the groundbreaking research that earn...

www.youtube.com

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 14

thank you dear luca for organizing this great meeting and having me. i had great time attending the fantastic diverse sessions and talks. I look forward for next one me and my lab embers would certainly become regular attendees.

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 12

12/n last one (plenty more but u should get the point by now) - iEFCs=60h in Preprint are shown to have a mix of PrE/Epi/TE , while in Paper they are homogeneously labeled in Magenta?

Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 12

11/n in relation to the above concern, another panel of Paper in Fig.3F 32C ICM are marked (left) and according to this analysis on dataset used they also highly overlap with 16-Cell labeled in green? yet again why drown in scRNA-seq when immunostainings r so easy to solve this ?

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 12

10/n some meta-analysis was done to claim iEFC fall on 8 cell. Upon close inspection - 8C and 32ICM r coloured similarly! and there is NO arrow pointing to 32ICM on the UMAP. it seems 32ICM cells are nicely overlapping with iEFCs? where is 64cell ICM? But again, simple scRNA-seq above says it all!

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 12

9/n Straightforward scRNA-seq analysis of 60h=iEFC in Preprint also showed cells are not going backwards in development, but forward. Gata6+ cells express Sox17 and Pdgfra which are not 8-16cell markers but of good old E4.5 PrE cells.

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 12

8/n Strangely straightforward scRNA-seq analysis of 60h=iEFC in Preprint showing rare CDX2/GATA6 coexpression & and that iEFC is basically a mix of Epi/PrE/TE, was NOT included in the published Paper although same dataset was used in both. & Nanog is reduced in TE-&PrE-like cells.

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 12

7/n Preprint: 3/3 iEFC stainings show no/rare CDX2+/GATA6+ (include the same 2 above) and one in Preprint Fig1C, which was replaced in Paper Fig 1E with one that shows fuzzy coexpression. In sum 3 out of 4 immunostainings shown, rare CDX2/GATA6 co-expression!

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 12

6/n why drown in intracellular stainings? Immunostaining for these markers r very easy to do in EFC=60h (names of same between Paper & Preprint tinyurl.com/tu6cv3cd). No quantitative & wideview stainings r shown. 2/3 iEFC stainings in Paper show no/rare CDX2+/GATA6+.

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 12

5/n why is this important? We need to distinguish btwn: 1)Naive ESC reverting back to 8-16 cell "EFCs"= most cells co-expressing OCT4/CDX2/GATA6 2)Naive ESC partially/on their way differentiating into TE or PrE = resulting in OCT4+ cells with CDX2+ or GATA6+, NOT CDX2/GATA6 co-expressed

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Jacob (Yaqub) Hanna - يعقوب حنا @jacob-hanna.bsky.social · Aug 12

4/n These discrepancies using same data controls & samples between preprint and paper are very concerning. Gating strategy & methods not shown explained in paper, but this change shows the authors are determining gating based on signal detected in ESC sample and not EFC (60h) own negative controls.

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